Literature summary extracted from

Broeyer, F.J.; van Aken, B.E.; Suzuki, J.; Kemme, M.J.; Schoemaker, H.C.; Cohen, A.F.; Mizushima, Y.; Burggraaf, J.
The pharmacokinetics and effects of a long-acting preparation of superoxide dismutase (PC-SOD) in man (2008), Br. J. Clin. Pharmacol., 65, 22-29.

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
1.15.1.1	expression of the CuZn-SOD in Escherichia coli	Homo sapiens

Metals/Ions

EC Number	Metals/Ions	Comment	Organism	Structure
1.15.1.1	Cu2+	a CuZn-SOD	Homo sapiens
1.15.1.1	Zn2+	a CuZn-SOD	Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
1.15.1.1	additional information	Homo sapiens	pharmacokinetics, safety and tolerability of single rising doses up to 80 mg of recombinant human superoxide dismutase covalently linked to lecithin in healthy white volunteers, overview	?	-	?
1.15.1.1	O2.- + H+	Homo sapiens	-	O2 + H2O2	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.15.1.1	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.15.1.1	additional information	measurement of serum and urinary PC-Cu,Zn-SOD concentrations after application of exogenous recombinant human isozyme to male and female humans, overview	Homo sapiens	-

Specific Activity [micromol/min/mg]

EC Number	Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
1.15.1.1	additional information	-	SOD activity profile after intravenous administration of Cu,Zn-SOD covalently linked to lecithin, measurement of serum and urinary PC-Cu,Zn-SOD concentrations after application of exogenous recombinant human isozyme to male and female humans, overview	Homo sapiens

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.15.1.1	additional information	pharmacokinetics, safety and tolerability of single rising doses up to 80 mg of recombinant human superoxide dismutase covalently linked to lecithin in healthy white volunteers, overview	Homo sapiens	?	-	?
1.15.1.1	O2.- + H+	-	Homo sapiens	O2 + H2O2	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
1.15.1.1	CuZn-SOD	-	Homo sapiens
1.15.1.1	SOD	-	Homo sapiens

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Release 2023.1 (January 2023)