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Literature summary extracted from

  • Shang, C.H.; Zhu, F.; Li, N.; Ou-Yang, X.; Shi, L.; Zhao, M.W.; Li, Y.X.
    Cloning and characterization of a gene encoding HMG-CoA reductase from Ganoderma lucidum and its functional identification in yeast (2008), Biosci. Biotechnol. Biochem., 72, 1333-1339.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.34 DNA and amino aid sequence determination and analysis, cloning in Escherichia coli and functional complementation of a HMGR-deficient mutant yeast strain using the yeast-Escherichia coli coli shuttle vector pYF1845 Ganoderma lucidum

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.34 membrane
-
 Ganoderma lucidum 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.34 hydroxymethylglutaryl-CoA + NADPH + H+ Ganoderma lucidum
-
 mevalonate + NADP+ + CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.34 Ganoderma lucidum B2KX91 a triterpene-producing fungus, strain HG
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.34 hydroxymethylglutaryl-CoA + NADPH + H+
-
 Ganoderma lucidum mevalonate + NADP+ + CoA
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.34 3-hydroxy-3-methylglutaryl-coenzyme A reductase
-
 Ganoderma lucidum
1.1.1.34 HMGR
-
 Ganoderma lucidum

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.34 NADPH dependent on Ganoderma lucidum