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Literature summary extracted from

  • Xin, Z.; Zhao, H.; Serby, M.D.; Liu, B.; Liu, M.; Szczepankiewicz, B.G.; Nelson, L.T.; Smith, H.T.; Suhar, T.S.; Janis, R.S.; Cao, N.; Camp, H.S.; Collins, C.A.; Sham, H.L.; Surowy, T.K.; Liu, G.
    Discovery of piperidine-aryl urea-based stearoyl-CoA desaturase 1 inhibitors (2008), Bioorg. Med. Chem. Lett., 18, 4298-4302.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.19.1 4-(2-bromophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide
-
Homo sapiens
1.14.19.1 4-(2-bromophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide
-
Mus musculus
1.14.19.1 4-(2-chloro-4-fluorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide
-
Homo sapiens
1.14.19.1 4-(2-chloro-4-fluorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide
-
Mus musculus
1.14.19.1 4-(2-chloro-5-fluorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide
-
Homo sapiens
1.14.19.1 4-(2-chloro-5-fluorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide
-
Mus musculus
1.14.19.1 4-(2-chloro-6-fluorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide
-
Homo sapiens
1.14.19.1 4-(2-chloro-6-fluorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide
-
Mus musculus
1.14.19.1 4-(2-chlorophenoxy)-N-phenylpiperidine-1-carboxamide
-
Homo sapiens
1.14.19.1 4-(2-chlorophenoxy)-N-phenylpiperidine-1-carboxamide
-
Mus musculus
1.14.19.1 4-(2-chlorophenoxy)-N-[3-(1H-imidazol-2-yl)phenyl]piperidine-1-carboxamide
-
Homo sapiens
1.14.19.1 4-(2-chlorophenoxy)-N-[3-(1H-imidazol-2-yl)phenyl]piperidine-1-carboxamide
-
Mus musculus
1.14.19.1 4-(2-chlorophenoxy)-N-[3-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl]piperidine-1-carboxamide
-
Homo sapiens
1.14.19.1 4-(2-chlorophenoxy)-N-[3-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl]piperidine-1-carboxamide
-
Mus musculus
1.14.19.1 4-(2-chlorophenoxy)-N-[3-(ethylcarbamoyl)phenyl]piperidine-1-carboxamide
-
Homo sapiens
1.14.19.1 4-(2-chlorophenoxy)-N-[3-(ethylcarbamoyl)phenyl]piperidine-1-carboxamide
-
Mus musculus
1.14.19.1 4-(2-chlorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide
-
Homo sapiens
1.14.19.1 4-(2-chlorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide
-
Mus musculus
1.14.19.1 4-(2-chlorophenoxy)-N-[3-[(1-methylethyl)carbamoyl]phenyl]piperidine-1-carboxamide
-
Homo sapiens
1.14.19.1 4-(2-chlorophenoxy)-N-[3-[(1-methylethyl)carbamoyl]phenyl]piperidine-1-carboxamide
-
Mus musculus
1.14.19.1 4-(2-fluorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide
-
Homo sapiens
1.14.19.1 4-(2-fluorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide
-
Mus musculus
1.14.19.1 4-(2-methoxyphenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide
-
Homo sapiens
1.14.19.1 4-(2-methoxyphenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide
-
Mus musculus
1.14.19.1 4-(3-chlorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide
-
Homo sapiens
1.14.19.1 4-(3-chlorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide
-
Mus musculus
1.14.19.1 additional information design and synthesis of piperidine-aryl urea-based stearoyl-CoA desaturase1 inhibitors, overview Homo sapiens
1.14.19.1 additional information design and synthesis of piperidine-aryl urea-based stearoyl-CoA desaturase1 inhibitors, overview Mus musculus
1.14.19.1 N-(3-carbamoylphenyl)-4-(2-chlorophenoxy)piperidine-1-carboxamide
-
Homo sapiens
1.14.19.1 N-(3-carbamoylphenyl)-4-(2-chlorophenoxy)piperidine-1-carboxamide
-
Mus musculus
1.14.19.1 N-[3-(methylcarbamoyl)phenyl]-4-(2-methylphenoxy)piperidine-1-carboxamide
-
Homo sapiens
1.14.19.1 N-[3-(methylcarbamoyl)phenyl]-4-(2-methylphenoxy)piperidine-1-carboxamide
-
Mus musculus
1.14.19.1 N-[3-(methylcarbamoyl)phenyl]-4-phenoxypiperidine-1-carboxamide
-
Homo sapiens
1.14.19.1 N-[3-(methylcarbamoyl)phenyl]-4-phenoxypiperidine-1-carboxamide
-
Mus musculus
1.14.19.1 N-[3-(tert-butylcarbamoyl)phenyl]-4-(2-chlorophenoxy)piperidine-1-carboxamide
-
Homo sapiens
1.14.19.1 N-[3-(tert-butylcarbamoyl)phenyl]-4-(2-chlorophenoxy)piperidine-1-carboxamide
-
Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.19.1 stearoyl-CoA + ferrocytochrome b5 + O2 + H+ Mus musculus
-
oleoyl-CoA + ferricytochrome b5 + H2O
-
?
1.14.19.1 stearoyl-CoA + ferrocytochrome b5 + O2 + H+ Homo sapiens
-
oleoyl-CoA + ferricytochrome b5 + H2O
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.14.19.1 Homo sapiens
-
-
-
1.14.19.1 Mus musculus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.19.1 stearoyl-CoA + ferrocytochrome b5 + O2 + H+
-
Mus musculus oleoyl-CoA + ferricytochrome b5 + H2O
-
?
1.14.19.1 stearoyl-CoA + ferrocytochrome b5 + O2 + H+
-
Homo sapiens oleoyl-CoA + ferricytochrome b5 + H2O
-
?

Synonyms

EC Number Synonyms Comment Organism
1.14.19.1 SCD1
-
Mus musculus
1.14.19.1 SCD1
-
Homo sapiens
1.14.19.1 stearoyl-CoA desaturase 1
-
Mus musculus
1.14.19.1 stearoyl-CoA desaturase 1
-
Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.19.1 ferrocytochrome b5
-
Mus musculus
1.14.19.1 ferrocytochrome b5
-
Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.14.19.1 0.000004
-
below Mus musculus 4-(2-chlorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide
1.14.19.1 0.000004
-
below Mus musculus 4-(2-bromophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide
1.14.19.1 0.000004
-
below Mus musculus 4-(2-chloro-5-fluorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide
1.14.19.1 0.000006
-
-
Mus musculus 4-(2-chloro-4-fluorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide
1.14.19.1 0.000008
-
-
Mus musculus 4-(2-chlorophenoxy)-N-[3-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl]piperidine-1-carboxamide
1.14.19.1 0.000008
-
-
Mus musculus 4-(2-chlorophenoxy)-N-[3-(ethylcarbamoyl)phenyl]piperidine-1-carboxamide
1.14.19.1 0.00001
-
-
Mus musculus 4-(2-chlorophenoxy)-N-[3-(1H-imidazol-2-yl)phenyl]piperidine-1-carboxamide
1.14.19.1 0.00001
-
-
Mus musculus N-(3-carbamoylphenyl)-4-(2-chlorophenoxy)piperidine-1-carboxamide
1.14.19.1 0.000017
-
-
Mus musculus N-[3-(methylcarbamoyl)phenyl]-4-(2-methylphenoxy)piperidine-1-carboxamide
1.14.19.1 0.000018
-
-
Homo sapiens 4-(2-chloro-5-fluorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide
1.14.19.1 0.00002
-
-
Mus musculus 4-(3-chlorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide
1.14.19.1 0.00003
-
-
Homo sapiens 4-(2-bromophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide
1.14.19.1 0.000037
-
-
Homo sapiens 4-(2-chlorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide
1.14.19.1 0.000058
-
-
Homo sapiens 4-(2-chloro-4-fluorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide
1.14.19.1 0.000059
-
-
Homo sapiens N-(3-carbamoylphenyl)-4-(2-chlorophenoxy)piperidine-1-carboxamide
1.14.19.1 0.000081
-
-
Mus musculus 4-(2-methoxyphenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide
1.14.19.1 0.000098
-
-
Mus musculus 4-(2-fluorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide
1.14.19.1 0.00011
-
-
Homo sapiens 4-(2-chlorophenoxy)-N-[3-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl]piperidine-1-carboxamide
1.14.19.1 0.00012
-
-
Homo sapiens N-[3-(methylcarbamoyl)phenyl]-4-(2-methylphenoxy)piperidine-1-carboxamide
1.14.19.1 0.00015
-
-
Homo sapiens 4-(2-chlorophenoxy)-N-[3-(ethylcarbamoyl)phenyl]piperidine-1-carboxamide
1.14.19.1 0.00027
-
-
Homo sapiens 4-(3-chlorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide
1.14.19.1 0.00033
-
-
Mus musculus 4-(2-chloro-6-fluorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide
1.14.19.1 0.00036
-
-
Homo sapiens 4-(2-chlorophenoxy)-N-[3-(1H-imidazol-2-yl)phenyl]piperidine-1-carboxamide
1.14.19.1 0.00037
-
-
Mus musculus N-[3-(methylcarbamoyl)phenyl]-4-phenoxypiperidine-1-carboxamide
1.14.19.1 0.00059
-
-
Mus musculus 4-(2-chlorophenoxy)-N-phenylpiperidine-1-carboxamide
1.14.19.1 0.00068
-
-
Homo sapiens 4-(2-fluorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide
1.14.19.1 0.00081
-
-
Mus musculus 4-(2-chlorophenoxy)-N-[3-[(1-methylethyl)carbamoyl]phenyl]piperidine-1-carboxamide
1.14.19.1 0.0019
-
-
Homo sapiens 4-(2-methoxyphenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide
1.14.19.1 0.004
-
-
Homo sapiens N-[3-(methylcarbamoyl)phenyl]-4-phenoxypiperidine-1-carboxamide
1.14.19.1 0.0071
-
-
Homo sapiens 4-(2-chlorophenoxy)-N-[3-[(1-methylethyl)carbamoyl]phenyl]piperidine-1-carboxamide
1.14.19.1 0.0075
-
-
Homo sapiens 4-(2-chlorophenoxy)-N-phenylpiperidine-1-carboxamide
1.14.19.1 0.0097
-
-
Homo sapiens 4-(2-chloro-6-fluorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide
1.14.19.1 0.01
-
above Mus musculus N-[3-(tert-butylcarbamoyl)phenyl]-4-(2-chlorophenoxy)piperidine-1-carboxamide
1.14.19.1 0.01
-
above Homo sapiens N-[3-(tert-butylcarbamoyl)phenyl]-4-(2-chlorophenoxy)piperidine-1-carboxamide