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Literature summary extracted from

  • Clift, M.D.; Silverman, R.B.
    Synthesis and evaluation of novel aromatic substrates and competitive inhibitors of GABA aminotransferase (2008), Bioorg. Med. Chem. Lett., 18, 3122-3125.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.6.1.19 docking calculations for substrates 3-(aminomethyl)benzoic acid, [3-(aminomethyl)phenyl]acetic acid and [2-(aminomethyl)phenyl]acetic acid, using the crystallographic structure of the enzyme in complex with vigabatrin Sus scrofa

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.6.1.19 3-(aminomethyl)benzoic acid poor competitive inhibitor Sus scrofa
2.6.1.19 [2-(aminomethyl)phenyl]acetic acid poor competitive inhibitor Sus scrofa
2.6.1.19 [3-(aminomethyl)phenyl]acetic acid poor competitive inhibitor Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.19 Sus scrofa P80147
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.6.1.19 liver
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.19 3-(aminomethyl)benzoic acid + 2-oxoglutarate 3.4% of the activity with 4-aminobutanoate Sus scrofa 3-(iminomethyl)benzoic acid + L-glutamate
-
 ?
2.6.1.19 4-aminobutanoate + 2-oxoglutarate
-
 Sus scrofa 4-oxobutanoate + L-glutamate
-
 ?
2.6.1.19 [2-(aminomethyl)phenyl]acetic acid + 2-oxoglutarate 5.65% of the activity with 4-aminobutanoate Sus scrofa (2-formylphenyl)acetic acid + L-glutamate
-
 ?
2.6.1.19 [3-(aminomethyl)phenyl]acetic acid + 2-oxoglutarate 0.78% of the activity with 4-aminobutanoate Sus scrofa (3-formylphenyl)acetic acid + L-glutamate
-
 ?