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Literature summary extracted from
- Amidohydrolases of the reductive pyrimidine catabolic pathway: Purification, characterization, structure, reaction mechanisms and enzyme deficiency (2008), Biochim. Biophys. Acta, 1784, 431-444.
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 3.5.2.2 | R412M | inactive | Homo sapiens |
| 3.5.2.2 | W360R | inactive | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.5.1.6 | 4-ureidobutyrate | - |
Bos taurus |  |
| 3.5.1.6 | glutarate monoamide | - |
Bos taurus | |
| 3.5.1.6 | Isobutyrate | - |
Euglena gracilis | |
| 3.5.1.6 | propionate | - |
Bos taurus | |
| 3.5.1.6 | propionate | - |
Euglena gracilis | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.5.1.6 | 0.008 | - |
N-Carbamoyl-beta-alanine | - |
Rattus norvegicus | |
| 3.5.1.6 | 0.008 | - |
N-Carbamoyl-beta-alanine | - |
Arabidopsis thaliana | |
| 3.5.1.6 | 0.011 | - |
N-Carbamoyl-beta-alanine | - |
Zea mays | |
| 3.5.1.6 | 0.022 | - |
N-Carbamoyl-beta-alanine | - |
Bos taurus | |
| 3.5.1.6 | 4 | - |
N-Carbamoyl-beta-alanine | - |
Pseudomonas putida | |
| 3.5.1.6 | 50 | - |
N-Carbamoyl-beta-alanine | value above 50 mM | Lachancea kluyveri | |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.5.1.6 | Co2+ | - |
Pseudomonas putida | |
| 3.5.1.6 | Zn2+ | - |
Rattus norvegicus | |
| 3.5.1.6 | Zn2+ | - |
Zea mays | |
| 3.5.1.6 | Zn2+ | two Zn2+ ions per subunit | Lachancea kluyveri | |
| 3.5.2.2 | Zn2+ | zinc-metalloenzyme | Homo sapiens | |
| 3.5.2.2 | Zn2+ | zinc-metalloenzyme | Rattus norvegicus | |
| 3.5.2.2 | Zn2+ | zinc-metalloenzyme | Bos taurus | |
| 3.5.2.2 | Zn2+ | zinc-metalloenzyme | Dictyostelium discoideum | |
| 3.5.2.2 | Zn2+ | zinc-metalloenzyme | Lachancea kluyveri | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.5.1.6 | additional information | - |
native oligomerization state: 1.5 - 2 MDa | Euglena gracilis |
| 3.5.1.6 | 40000 | - |
6 * 40000 Da | Bos taurus |
| 3.5.1.6 | 42000 | - |
6 * 42000 Da | Rattus norvegicus |
| 3.5.1.6 | 44000 | - |
10 * 44000 | Zea mays |
| 3.5.1.6 | 45000 | - |
2 * 45000 Da | Pseudomonas putida |
| 3.5.1.6 | 45500 | - |
10 * 45500 | Arabidopsis thaliana |
| 3.5.1.6 | 50000 | - |
2 * 50000 | Lachancea kluyveri |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.5.1.6 | Arabidopsis thaliana | - |
- |
- |
| 3.5.1.6 | Bos taurus | - |
- |
- |
| 3.5.1.6 | Caenorhabditis elegans | - |
- |
- |
| 3.5.1.6 | Dictyostelium discoideum | - |
- |
- |
| 3.5.1.6 | Drosophila melanogaster | - |
- |
- |
| 3.5.1.6 | Euglena gracilis | - |
- |
- |
| 3.5.1.6 | Homo sapiens | - |
- |
- |
| 3.5.1.6 | Lachancea kluyveri | - |
- |
- |
| 3.5.1.6 | Pseudomonas putida | - |
- |
- |
| 3.5.1.6 | Rattus norvegicus | - |
- |
- |
| 3.5.1.6 | Zea mays | - |
- |
- |
| 3.5.2.2 | Bos taurus | - |
- |
- |
| 3.5.2.2 | Dictyostelium discoideum | - |
- |
- |
| 3.5.2.2 | Homo sapiens | - |
- |
- |
| 3.5.2.2 | Lachancea kluyveri | - |
- |
- |
| 3.5.2.2 | Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.5.1.6 | - |
Homo sapiens |
| 3.5.1.6 | - |
Rattus norvegicus |
| 3.5.1.6 | - |
Bos taurus |
| 3.5.1.6 | - |
Pseudomonas putida |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.5.1.6 | liver | - |
Rattus norvegicus | - |
| 3.5.1.6 | liver | calf | Bos taurus | - |
| 3.5.2.2 | liver | - |
Rattus norvegicus | - |
| 3.5.2.2 | liver | - |
Bos taurus | - |
| 3.5.2.2 | liver | - |
Dictyostelium discoideum | - |
| 3.5.2.2 | liver | - |
Lachancea kluyveri | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.5.1.6 | N-carbamoyl-beta-alanine + H2O | - |
Drosophila melanogaster | beta-alanine + CO2 + NH3 | - |
? | |
| 3.5.1.6 | N-carbamoyl-beta-alanine + H2O | - |
Homo sapiens | beta-alanine + CO2 + NH3 | - |
? | |
| 3.5.1.6 | N-carbamoyl-beta-alanine + H2O | - |
Rattus norvegicus | beta-alanine + CO2 + NH3 | - |
? | |
| 3.5.1.6 | N-carbamoyl-beta-alanine + H2O | - |
Bos taurus | beta-alanine + CO2 + NH3 | - |
? | |
| 3.5.1.6 | N-carbamoyl-beta-alanine + H2O | - |
Euglena gracilis | beta-alanine + CO2 + NH3 | - |
? | |
| 3.5.1.6 | N-carbamoyl-beta-alanine + H2O | - |
Zea mays | beta-alanine + CO2 + NH3 | - |
? | |
| 3.5.1.6 | N-carbamoyl-beta-alanine + H2O | - |
Arabidopsis thaliana | beta-alanine + CO2 + NH3 | - |
? | |
| 3.5.1.6 | N-carbamoyl-beta-alanine + H2O | - |
Pseudomonas putida | beta-alanine + CO2 + NH3 | - |
? | |
| 3.5.1.6 | N-carbamoyl-beta-alanine + H2O | - |
Dictyostelium discoideum | beta-alanine + CO2 + NH3 | - |
? | |
| 3.5.1.6 | N-carbamoyl-beta-alanine + H2O | - |
Lachancea kluyveri | beta-alanine + CO2 + NH3 | - |
? | |
| 3.5.1.6 | N-carbamoyl-beta-aminoisobutyrate + H2O | - |
Drosophila melanogaster | beta-aminoisobutyrate + CO2 + NH3 | - |
? | |
| 3.5.1.6 | N-carbamoyl-beta-aminoisobutyrate + H2O | - |
Homo sapiens | beta-aminoisobutyrate + CO2 + NH3 | - |
? | |
| 3.5.1.6 | N-carbamoyl-beta-aminoisobutyrate + H2O | - |
Rattus norvegicus | beta-aminoisobutyrate + CO2 + NH3 | - |
? | |
| 3.5.1.6 | N-carbamoyl-beta-aminoisobutyrate + H2O | - |
Bos taurus | beta-aminoisobutyrate + CO2 + NH3 | - |
? | |
| 3.5.1.6 | N-carbamoyl-beta-aminoisobutyrate + H2O | - |
Euglena gracilis | beta-aminoisobutyrate + CO2 + NH3 | - |
? | |
| 3.5.1.6 | N-carbamoyl-beta-aminoisobutyrate + H2O | - |
Zea mays | beta-aminoisobutyrate + CO2 + NH3 | - |
? | |
| 3.5.1.6 | N-carbamoyl-beta-aminoisobutyrate + H2O | - |
Arabidopsis thaliana | beta-aminoisobutyrate + CO2 + NH3 | - |
? | |
| 3.5.1.6 | N-carbamoyl-beta-aminoisobutyrate + H2O | - |
Pseudomonas putida | beta-aminoisobutyrate + CO2 + NH3 | - |
? | |
| 3.5.1.6 | N-carbamoyl-beta-aminoisobutyrate + H2O | - |
Dictyostelium discoideum | beta-aminoisobutyrate + CO2 + NH3 | - |
? | |
| 3.5.1.6 | N-carbamoyl-beta-aminoisobutyrate + H2O | - |
Lachancea kluyveri | beta-aminoisobutyrate + CO2 + NH3 | - |
? | |
| 3.5.1.6 | N-carbamyl-beta-alanine + H2O | - |
Caenorhabditis elegans | beta-alanine + CO2 + NH3 | - |
? | |
| 3.5.1.6 | N-carbamyl-beta-aminoisobutyrate + H2O | - |
Caenorhabditis elegans | beta-aminoisobutyrate + CO2 + NH3 | - |
? | |
| 3.5.2.2 | 5,6-dihydrothymine + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.5.2.2 | 5,6-dihydrothymine + H2O | - |
Rattus norvegicus | ? | - |
? | |
| 3.5.2.2 | 5,6-dihydrothymine + H2O | - |
Bos taurus | ? | - |
? | |
| 3.5.2.2 | 5,6-dihydrothymine + H2O | - |
Dictyostelium discoideum | ? | - |
? | |
| 3.5.2.2 | 5,6-dihydrothymine + H2O | - |
Lachancea kluyveri | ? | - |
? | |
| 3.5.2.2 | 5,6-dihydrouracil + H2O | - |
Homo sapiens | 3-ureidopropionate | - |
? | |
| 3.5.2.2 | 5,6-dihydrouracil + H2O | - |
Rattus norvegicus | 3-ureidopropionate | - |
? | |
| 3.5.2.2 | 5,6-dihydrouracil + H2O | - |
Bos taurus | 3-ureidopropionate | - |
? | |
| 3.5.2.2 | 5,6-dihydrouracil + H2O | - |
Dictyostelium discoideum | 3-ureidopropionate | - |
? | |
| 3.5.2.2 | 5,6-dihydrouracil + H2O | - |
Lachancea kluyveri | 3-ureidopropionate | - |
? | |
| 3.5.2.2 | additional information | does not hydrolyze hydantoins | Dictyostelium discoideum | ? | - |
? | |
| 3.5.2.2 | additional information | does not hydrolyze hydantoins | Lachancea kluyveri | ? | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 3.5.1.6 | dimer | 2 * 45000 Da | Pseudomonas putida |
| 3.5.1.6 | homodecamer | 10 * 44000 | Zea mays |
| 3.5.1.6 | homodecamer | 10 * 45500 | Arabidopsis thaliana |
| 3.5.1.6 | homodimer | - |
Homo sapiens |
| 3.5.1.6 | homodimer | 2 * 50000 | Lachancea kluyveri |
| 3.5.1.6 | homohexamer | 6 * 40000 Da | Bos taurus |
| 3.5.1.6 | homohexamer | 6 * 42000 Da | Rattus norvegicus |
| 3.5.1.6 | More | subunit: 44000 Da | Drosophila melanogaster |
| 3.5.2.2 | homotetramer | - |
Homo sapiens |
| 3.5.2.2 | homotetramer | - |
Rattus norvegicus |
| 3.5.2.2 | homotetramer | - |
Bos taurus |
| 3.5.2.2 | homotetramer | - |
Dictyostelium discoideum |
| 3.5.2.2 | homotetramer | - |
Lachancea kluyveri |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.5.1.6 | beta-alanine synthase | - |
Drosophila melanogaster |
| 3.5.1.6 | beta-alanine synthase | - |
Homo sapiens |
| 3.5.1.6 | beta-alanine synthase | - |
Rattus norvegicus |
| 3.5.1.6 | beta-alanine synthase | - |
Bos taurus |
| 3.5.1.6 | beta-alanine synthase | - |
Euglena gracilis |
| 3.5.1.6 | beta-alanine synthase | - |
Zea mays |
| 3.5.1.6 | beta-alanine synthase | - |
Arabidopsis thaliana |
| 3.5.1.6 | beta-alanine synthase | - |
Pseudomonas putida |
| 3.5.1.6 | beta-alanine synthase | - |
Dictyostelium discoideum |
| 3.5.1.6 | beta-alanine synthase | - |
Caenorhabditis elegans |
| 3.5.1.6 | beta-alanine synthase | - |
Lachancea kluyveri |
| 3.5.2.2 | DHPase | - |
Homo sapiens |
| 3.5.2.2 | DHPase | - |
Rattus norvegicus |
| 3.5.2.2 | DHPase | - |
Bos taurus |
| 3.5.2.2 | DHPase | - |
Dictyostelium discoideum |
| 3.5.2.2 | DHPase | - |
Lachancea kluyveri |
| 3.5.2.2 | dihydropyrimidine amidohydrolase | - |
Homo sapiens |
| 3.5.2.2 | dihydropyrimidine amidohydrolase | - |
Rattus norvegicus |
| 3.5.2.2 | dihydropyrimidine amidohydrolase | - |
Bos taurus |
| 3.5.2.2 | dihydropyrimidine amidohydrolase | - |
Dictyostelium discoideum |
| 3.5.2.2 | dihydropyrimidine amidohydrolase | - |
Lachancea kluyveri |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.5.1.6 | 0.0016 | - |
4-ureidobutyrate | - |
Bos taurus | |
| 3.5.1.6 | 0.24 | - |
propionate | - |
Bos taurus | |
| 3.5.1.6 | 0.63 | - |
glutarate monoamide | - |
Bos taurus | |
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