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Literature summary extracted from
- Molecular cloning and characterization of ouabain-insensitive Na+-ATPase in the parasitic protist, Trypanosoma cruzi (2006), Biochim. Biophys. Acta, 1758, 738-746.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 7.2.2.3 | K+ | - |
Trypanosoma cruzi |  |
| 7.2.2.3 | Na+ | - |
Trypanosoma cruzi | |
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 7.2.2.3 | into tht pCR II-TOPO vector, into the mammalian expression vector pEGFP-N1 for transfection of FreeStyle 293-F cells, and into the trypanosomatid shuttle vector pTREX for transformation of Trypanosoma cruzi epimastigotes | Trypanosoma cruzi |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 7.2.2.3 | orthovanadate | - |
Trypanosoma cruzi | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 7.2.2.3 | plasma membrane | - |
Trypanosoma cruzi | 5886 | - |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 7.2.2.3 | 120000 | - |
calculated molecular mass, determined by SDS-PAGE and Western-blotting | Trypanosoma cruzi |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 7.2.2.3 | ATP + H2O + Na+/in | Trypanosoma cruzi | - |
ADP + phosphate + Na+/out | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 7.2.2.3 | Trypanosoma cruzi | Q76DT8 | - |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 7.2.2.3 | ATP + H2O + Na+/in | - |
Trypanosoma cruzi | ADP + phosphate + Na+/out | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 7.2.2.3 | ENA | - |
Trypanosoma cruzi |
| 7.2.2.3 | Na+-ATPase | - |
Trypanosoma cruzi |
| 7.2.2.3 | Na+-exporting ATPase | - |
Trypanosoma cruzi |
| 7.2.2.3 | TcENA | - |
Trypanosoma cruzi |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 7.2.2.3 | 37 | - |
ATPase activity assay | Trypanosoma cruzi |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 7.2.2.3 | 7.6 | - |
ATPase activity assay | Trypanosoma cruzi |
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Release 2023.1 (January 2023)
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