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Literature summary extracted from

  • Le, D.T.; Liang, X.; Fomenko, D.E.; Raza, A.S.; Chong, C.K.; Carlson, B.A.; Hatfield, D.L.; Gladyshev, V.N.
    Analysis of methionine/selenomethionine oxidation and methionine sulfoxide reductase function using methionine-rich proteins and antibodies against their oxidized forms (2008), Biochemistry, 47, 6685-6694.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.8.4.11 protein-L-methionine (S)-S-oxide + thioredoxin Mus musculus Met sulfoxide residues in Met-rich proteins can be reduced by MsrA and MsrB protein-L-methionine + thioredoxin disulfide + H2O
-
 ?
1.8.4.12 protein-L-methionine (R)-S-oxide + dithiothreitol Mus musculus Met sulfoxide residues in an Met-rich proteins can be reduced by MsrA and MsrB protein-L-methionine + dithiothreitol disulfide + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.8.4.11 Mus musculus Q9D6Y7
-
-
1.8.4.12 Mus musculus Q78J03
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.4.11 protein-L-methionine (S)-S-oxide + thioredoxin Met sulfoxide residues in Met-rich proteins can be reduced by MsrA and MsrB Mus musculus protein-L-methionine + thioredoxin disulfide + H2O
-
 ?
1.8.4.12 protein-L-methionine (R)-S-oxide + dithiothreitol Met sulfoxide residues in an Met-rich proteins can be reduced by MsrA and MsrB Mus musculus protein-L-methionine + dithiothreitol disulfide + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.8.4.11 MsrA
-
 Mus musculus
1.8.4.12 MsrB2
-
 Mus musculus