EC Number | Crystallization (Comment) | Organism |
---|---|---|
1.2.7.4 | - |
Moorella thermoacetica |
2.3.1.169 | a 2.5 A resolution structure of xenon-pressurized CODH/ACS, examination of the nature of gaseous cavities within the enzyme. The cavity calculation program CAVENV accurately predicts the channels connecting the C- and A-clusters, with 17 of 19 xenon binding sites within the predicted regions. The enzyme has a channel for a small substrate, a channel plug, a flexible acetyl-CoA synthase subunit that can open to interact with a large substrate, and an interdomain cavity to putatively bind a medium-sized substrate | Moorella thermoacetica |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.2.7.4 | mitochondrion | - |
Moorella thermoacetica | 5739 | - |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
1.2.7.4 | Ni-Fe-S center | - |
Moorella thermoacetica | |
6.2.1.1 | Fe2+ | CODH/ACS uses a Ni-Fe-S center called the C-cluster to reduce carbon dioxide to carbon monoxide and uses a second Ni-Fe-S center, called the A-cluster, to assemble acetyl-CoA from a methyl group, coenzyme A, and C-cluster-generated CO | Moorella thermoacetica | |
6.2.1.1 | additional information | the enzyme uses seven metalloclusters in four reaction steps, overview | Moorella thermoacetica |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
6.2.1.1 | 310000 | - |
- |
Moorella thermoacetica |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
6.2.1.1 | additional information | Moorella thermoacetica | CODH/ACS is a bifunctional enzyme that is responsible for the reduction of CO2 to CO and subsequent assembly of acetyl-CoA, as part of the Wood-Ljungdahl carbon fixation pathway, the enzyme is a key player in the global carbon cycle | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.2.7.4 | Moorella thermoacetica | - |
formerly Clostridium thermoaceticum strain ATCC 39073 | - |
2.3.1.169 | Moorella thermoacetica | - |
bifunctional carbon monoxide dehydrogenase/acetyl-CoA synthase | - |
6.2.1.1 | Moorella thermoacetica | - |
formerly Clostridium thermoaceticum strain ATCC 39073 | - |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.2.7.4 | - |
Moorella thermoacetica |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.2.7.4 | CO + H2O + acceptor | - |
Moorella thermoacetica | CO2 + reduced acceptor | - |
? | |
1.2.7.4 | CO + H2O + acceptor | - |
Moorella thermoacetica | CO2 + reduced acceptor | - |
r | |
6.2.1.1 | additional information | CODH/ACS is a bifunctional enzyme that is responsible for the reduction of CO2 to CO and subsequent assembly of acetyl-CoA, as part of the Wood-Ljungdahl carbon fixation pathway, the enzyme is a key player in the global carbon cycle | Moorella thermoacetica | ? | - |
? | |
6.2.1.1 | additional information | the enzyme is a bifunctional carbon monoxide dehydrogenase/acetyl-CoA synthase, Moorella thermoacetica CODH/ACS contains a very long enzyme channel to allow for intermolecular CO transport, mechanism and reaction steps, overview. Structure-function analysis in comparison to monofunctional Acs, overview | Moorella thermoacetica | ? | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
1.2.7.4 | heterotetramer | x-ray crystallography | Moorella thermoacetica |
6.2.1.1 | More | Moorella thermoacetica CODH/ACS contains a very long enzyme channel to allow for intermolecular CO transport, overview | Moorella thermoacetica |
6.2.1.1 | tetramer | alpha2beta2 | Moorella thermoacetica |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.2.7.4 | carbon monoxide dehydrogenase/acetyl-CoA synthase | bifunctional enzyme | Moorella thermoacetica |
1.2.7.4 | CODH/ACS | - |
Moorella thermoacetica |
1.2.7.4 | CODH/ACS | bifunctional enzyme carbon monoxide dehydrogenase/acetyl-CoA synthase | Moorella thermoacetica |
6.2.1.1 | carbon monoxide dehydrogenase/acetyl-CoA synthase | - |
Moorella thermoacetica |
6.2.1.1 | mtCODH/ACS | - |
Moorella thermoacetica |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.2.7.4 | Ni-Fe-S center | uses a Ni-Fe-S center called the C-cluster to reduce carbon dioxide to carbon monoxide and uses a second Ni-Fe-S center, called the A-cluster, to assemble acetyl-CoA from a methyl group, coenzyme A, and C-cluster-generated CO | Moorella thermoacetica |