Literature summary extracted from

Chen, B.; Markillie, L.M.; Xiong, Y.; Mayer, M.U.; Squier, T.C.
Increased catalytic efficiency following gene fusion of bifunctional methionine sulfoxide reductase enzymes from Shewanella oneidensis (2007), Biochemistry, 46, 14153-14161.

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.8.4.11	Shewanella oneidensis	-	-	-
1.8.4.12	Shewanella oneidensis	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.8.4.11	calmodulin-L-methionine (S)-S-oxide + thioredoxin	MsrBA is able to completely reduce (i.e., repair) MetSO in the calcium regulatory protein calmodulin. The efficient repair is the coordinate activity of the two catalytic domains in the MsrBA fusion protein, which results in a 1 order of magnitude rate enhancement in comparison to those of the individual MsrA or MsrB enzyme alone	Shewanella oneidensis	calmodulin-L-methionine + thioredoxin disulfide + H2O	-	?
1.8.4.12	calmodulin-L-methionine (R)-S-oxide + thioredoxin	MsrBA is able to completely reduce (i.e., repair) MetSO in the calcium regulatory protein calmodulin. The efficient repair is the coordinate activity of the two catalytic domains in the MsrBA fusion protein, which results in a 1 order of magnitude rate enhancement in comparison to those of the individual MsrA or MsrB enzyme alone	Shewanella oneidensis	calmodulin-L-methionine + thioredoxin disulfide + H2O	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
1.8.4.11	MsrBA	bifunctional methionine sulfoxide reductase (EC 1.8.4.11/EC 1.8.4.12)	Shewanella oneidensis
1.8.4.12	MsrBA	bifunctional methionine sulfoxide reductase (EC 1.8.4.11/EC 1.8.4.12)	Shewanella oneidensis

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Release 2023.1 (January 2023)