EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.6.1.19 | (R,S)-4-amino-3-fluorobutanoic acid | the (R)-enantiomer inhibits the transamination of gamma-aminobutanoic acid 10 times more effectively than the (S)-enantiomer. On binding of free 4-amino-3-fluorobutanoic acid to enzyme the optimal conformation places the C-NH3 + and C-F bonds gauche in the (R)-enantiomer but anti in the (S)-enantiomer | Sus scrofa |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.6.1.19 | 0.045 | - |
(R,S)-4-amino-3-fluorobutanoic acid | pH 8.5 | Sus scrofa | |
2.6.1.19 | 0.059 | - |
(R)-4-amino-3-fluorobutanoic acid | pH 8.5 | Sus scrofa | |
2.6.1.19 | 2.6 | - |
gamma-aminobutanoic acid | pH 8.5 | Sus scrofa |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.6.1.19 | Sus scrofa | P80147 | - |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.6.1.19 | brain | - |
Sus scrofa | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
2.6.1.19 | 0.89 | - |
pH 8.5 | Sus scrofa |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.6.1.19 | (R)-4-amino-3-fluorobutanoic acid | - |
Sus scrofa | 4-aminobut-2-enoic acid + HF | - |
? | |
2.6.1.19 | (R,S)-4-amino-3-fluorobutanoic acid | neither enantiomer is a substrate for transamination. The rate of elimination of HF from the (R)-enantiomer is at least 10 times greater than that for the (S)-enantiomer | Sus scrofa | 4-aminobut-2-enoic acid + HF | - |
? | |
2.6.1.19 | gamma-aminobutyric acid | - |
Sus scrofa | ? | - |
? |