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Literature summary extracted from

  • Reenstra, W.W.; Crothers, J.; Forte, J.G.
    The conformation of H,K-ATPase determines the nucleoside triphosphate (NTP) selectivity for active proton transport (2007), Biochemistry, 46, 10145-10152.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
7.2.2.19 ADP activates NTPase activity of the enzyme Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.2.2.19 membrane
-
 Sus scrofa 16020
-
7.2.2.19 microsome
-
 Sus scrofa
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
7.2.2.19 K+ activates, required for ATPase activity Sus scrofa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.2.2.19 ATP + H2O + H+/in + K+/out Sus scrofa
-
 ADP + phosphate + H+/out + K+/in
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
7.2.2.19 Sus scrofa
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
7.2.2.19 partially by preparation of enzyme-enriched microsomal vesicles Sus scrofa

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.2.2.19 stomach mucosa Sus scrofa
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
7.2.2.19 additional information
-
 NTP hydrolysis activities, overview Sus scrofa
7.2.2.19 0.626
-
 ATP hydrolysis in presence of 10 mM K+ and 0.003 mM valinomycin Sus scrofa
7.2.2.19 0.641
-
 ATP hydrolysis in presence of 10 mM K+, 0.1 mM ADP, and 0.003 mM valinomycin Sus scrofa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.2.2.19 ATP + H2O + H+/in + K+/out
-
 Sus scrofa ADP + phosphate + H+/out + K+/in
-
 ?
7.2.2.19 additional information the enzyme also performs K+-dependent NTP hydrolysis, utilizing ATP, GTP, CTP, UTP, and ITP, and an NTP/ADP exchange reaction, overview Sus scrofa ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.2.2.19 H,K-ATPase
-
 Sus scrofa

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
7.2.2.19 37
-
 assay at Sus scrofa

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2.2.19 6.8
-
 assay at Sus scrofa