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Literature summary extracted from

  • Secondo, A.; De Mizio, M.; Zirpoli, L.; Santillo, M.; Mondola, P.
    The Cu-Zn superoxide dismutase (SOD1) inhibits ERK phosphorylation by muscarinic receptor modulation in rat pituitary GH3 cells (2008), Biochem. Biophys. Res. Commun., 376, 143-147.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.15.1.1 cytosol
-
 Rattus norvegicus 5829
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.15.1.1 Cu2+ isozyme Cu/Zn-SOD Rattus norvegicus
1.15.1.1 Zn2+ isozyme Cu/Zn-SOD Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.15.1.1 O2.- + H+ Rattus norvegicus SOD1 induces Ca2+ in the cell and inhibits ERK phosphorylation in the P-ERK1/2 pathway by muscarinic receptor M1 modulation in rat pituitary GH3 cells, the effect is enhanced by oxotremorine and partially reverted by pyrenzepine, and independent from increased intracellular calcium concentration, overview O2 + H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.15.1.1 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.15.1.1 GH3 cell
-
 Rattus norvegicus
-
1.15.1.1 additional information the enzyme is secreted by many cellular lines and it is also released trough a calcium-dependent depolarization mechanism involving SNARE protein SNAP 25 Rattus norvegicus
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1.15.1.1 pituitary gland
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.15.1.1 O2.- + H+
-
 Rattus norvegicus O2 + H2O2
-
 ?
1.15.1.1 O2.- + H+ SOD1 induces Ca2+ in the cell and inhibits ERK phosphorylation in the P-ERK1/2 pathway by muscarinic receptor M1 modulation in rat pituitary GH3 cells, the effect is enhanced by oxotremorine and partially reverted by pyrenzepine, and independent from increased intracellular calcium concentration, overview Rattus norvegicus O2 + H2O2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.15.1.1 Cu-Zn superoxide dismutase
-
 Rattus norvegicus
1.15.1.1 SOD1
-
 Rattus norvegicus