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Literature summary extracted from

  • Liu, S.; Yamauchi, H.
    Different patterns of 5alpha-reductase expression, cellular distribution, and testosterone metabolism in human follicular dermal papilla cells (2008), Biochem. Biophys. Res. Commun., 368, 858-864.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.22 finasteride 5alphaR2 inhibitor Homo sapiens
1.3.1.22 MK386 potent inhibitory effect on 5alphaR1 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.3.1.22 cytoplasm
-
 Homo sapiens 5737
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.3.1.22 26000
-
 5alphaR1, SDS-PAGE Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.22 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.1.22 dermal papilla cell from beard and axillary hair and frontal scalp hair Homo sapiens
-
1.3.1.22 fibroblast
-
 Homo sapiens
-
1.3.1.22 follicular dermal papilla cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.22 progesterone + NADPH + H+
-
 Homo sapiens 5alpha-pregnan-3,20-dione + NADP+
-
 ?
1.3.1.22 testosterone + NADPH + H+
-
 Homo sapiens 17beta-hydroxy-5alpha-androstan-3-one + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.1.22 5alphaR1
-
 Homo sapiens
1.3.1.22 5alphaR2
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.22 NADPH
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.3.1.22 0.0005
-
-
 Homo sapiens MK386
1.3.1.22 0.008
-
-
 Homo sapiens finasteride