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Literature summary extracted from

  • Weisinger, G.; Limor, R.; Marcus-Perlman, Y.; Knoll, E.; Kohen, F.; Schinder, V.; Firer, M.; Stern, N.
    12S-lipoxygenase protein associates with alpha-actin fibers in human umbilical artery vascular smooth muscle cells (2007), Biochem. Biophys. Res. Commun., 356, 554-560.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.31 baicalein inhibits the enzyme and its binding to cytoplasmic muscle fibrills, overview Homo sapiens
1.13.11.31 esculetine inhibits the enzyme and its binding to cytoplasmic muscle fibrills, overview Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.13.11.31 cytoplasm primarily associated with cytoplasmic vascular smooth muscle cell muscle fibrils binding to alpha-actin, a component of the cytoplasmic myofilaments, not associated with 12-LO serine or tyrosine phosphorylation, overview, the binding is induced by angiotensin II Homo sapiens 5737
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1.13.11.31 additional information subcellular distribution analysis, overview Homo sapiens
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Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.13.11.31 arachidonate + O2 Homo sapiens the platelet-type 12S-lipoxygenase isozyme is involved in angiotensin-II induced signaling in vascular smooth muscle cells (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyeicosa-5,8,10,14-tetraenoate
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 ?

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.31 Homo sapiens
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 platelet-type 12S-lipoxygenase isozyme
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.31 umbilical artery vascular smooth muscle, the enzyme associates with alpha-actin fibers Homo sapiens
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1.13.11.31 vascular smooth muscle umbilical artery, the enzyme associates with alpha-actin fibers Homo sapiens
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.31 arachidonate + O2
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 Homo sapiens (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyeicosa-5,8,10,14-tetraenoate
-
 ?
1.13.11.31 arachidonate + O2 the platelet-type 12S-lipoxygenase isozyme is involved in angiotensin-II induced signaling in vascular smooth muscle cells Homo sapiens (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyeicosa-5,8,10,14-tetraenoate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.13.11.31 12-LO
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 Homo sapiens
1.13.11.31 12S-lipoxygenase
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 Homo sapiens