Literature summary extracted from

Ward, J.R.; Dower, S.K.; Whyte, M.K.; Buttle, D.J.; Sabroe, I.
Potentiation of TLR4 signalling by plasmin activity (2006), Biochem. Biophys. Res. Commun., 341, 299-303.

Application

EC Number	Application	Comment	Organism
3.4.21.7	medicine	exerts proinflammatory functions. Direct activation of RAW264.7 cell monocytes by plasmin	synthetic construct

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.4.21.7	D-Val-Phe-Lys-chloromethyl ketone	inhibits the ability of plasmin to potentiate lipopolysaccharide signalling. Significantly inhibits the generation of TNFalpha from untransfected RAW cells after plasmin pretreatment and stimulated with LPS	synthetic construct
3.4.21.7	leupeptin	inhibits the ability of plasmin to potentiate lipopolysaccharide signalling	synthetic construct

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.21.7	synthetic construct	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.4.21.7	additional information	potentiates TLR2 and TLR4 signalling in RAW264.7 macrophages. Enhances endogenous production of TNFalpha and activation of an NF-kappaB reporter plasmid	synthetic construct	?	-	?
3.4.21.7	Suc-Ala-Phe-Lys-7-amido-4-methylcoumarin + H2O	-	synthetic construct	?	-	?

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Release 2023.1 (January 2023)