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Literature summary extracted from

  • Rodriguez, C.; Alcudia, J.F.; Martinez-Gonzalez, J.; Raposo, B.; Navarro, M.A.; Badimon, L.
    Lysyl oxidase (LOX) down-regulation by TNFalpha: a new mechanism underlying TNFalpha-induced endothelial dysfunction (2008), Atherosclerosis, 196, 558-564.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.3.13 TNFalpha TNFalpha decreases LOX mRNA levels in endothelial cells in a dose- and time-dependent manner (2fold at 1 ng/ml and maximum at 2.5 ng/ml) and endothelial LOX enzymatic activity Bos taurus
1.4.3.13 TNFalpha TNFalpha decreases LOX mRNA levels in endothelial cells in a dose- and time-dependent manner (2fold at 1 ng/ml and maximum at 2.5 ng/ml) and decreases endothelial LOX enzymatic activity Homo sapiens
1.4.3.13 TNFalpha TNFalpha decreases LOX mRNA levels in endothelial cells in a dose- and time-dependent manner (2fold at 1 ng/ml and maximum at 2.5 ng/ml) and endothelial LOX enzymatic activity Rattus norvegicus
1.4.3.13 TNFalpha TNFalpha decreases LOX mRNA levels in endothelial cells in a dose- and time-dependent manner (2fold at 1 ng/ml and maximum at 2.5 ng/ml) and endothelial LOX enzymatic activity Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.13 Bos taurus
-
-
-
1.4.3.13 Homo sapiens
-
-
-
1.4.3.13 Rattus norvegicus
-
-
-
1.4.3.13 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.4.3.13 aorta
-
 Rattus norvegicus
-
1.4.3.13 aortic endothelial cell
-
 Sus scrofa
-
1.4.3.13 aortic endothelial cell
-
 Bos taurus
-
1.4.3.13 BAEC cell
-
 Bos taurus
-
1.4.3.13 HUVEC cell
-
 Homo sapiens
-
1.4.3.13 porcine aortic endothelial cell
-
 Sus scrofa
-
1.4.3.13 umbilical vein endothelial cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.13 peptidyl-L-lysyl-peptide + O2 + H2O
-
 Homo sapiens peptidyl-allysyl-peptide + NH3 + H2O2
-
 ?
1.4.3.13 peptidyl-L-lysyl-peptide + O2 + H2O
-
 Rattus norvegicus peptidyl-allysyl-peptide + NH3 + H2O2
-
 ?
1.4.3.13 peptidyl-L-lysyl-peptide + O2 + H2O
-
 Sus scrofa peptidyl-allysyl-peptide + NH3 + H2O2
-
 ?
1.4.3.13 peptidyl-L-lysyl-peptide + O2 + H2O
-
 Bos taurus peptidyl-allysyl-peptide + NH3 + H2O2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.4.3.13 LOX
-
 Homo sapiens
1.4.3.13 LOX
-
 Rattus norvegicus
1.4.3.13 LOX
-
 Sus scrofa
1.4.3.13 LOX
-
 Bos taurus
1.4.3.13 lysyl oxidase
-
 Homo sapiens
1.4.3.13 lysyl oxidase
-
 Rattus norvegicus
1.4.3.13 lysyl oxidase
-
 Sus scrofa
1.4.3.13 lysyl oxidase
-
 Bos taurus