EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
1.13.11.63 | type I cellular retinol-binding protein | i.e. RBP1, RBP1, but not RBP2, is required for the transport of water-insoluble substrates of retinoid pathway enzymes, e.g. of BCMO1, into the cell, and acts as an intracellular sensor of retinoid status that, when present as apo-RBP1, stimulates BCMO1 activity and the conversion of carotenoids to retinoids | Mus musculus | |
1.13.11.63 | type I cellular retinol-binding protein | i.e. RBP1, RBP1, but not RBP2, is required for the transport of water-insoluble substrates of retinoid pathway enzymes, e.g. of BCMO1, into the cell, and acts as an intracellular sensor of retinoid status that, when present as apo-RBP1, stimulates BCMO1 activity and the conversion of carotenoids to retinoids | Homo sapiens |
EC Number | Cloned (Comment) | Organism |
---|---|---|
1.13.11.63 | EST library screening, DNA and amino acid sequence determination and analysis, expression of His-tagged enzyme in Escherichia coli | Homo sapiens |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
1.13.11.63 | additional information | phenotype of enzyme-deficient mice, beta-carotene conversion is blocked in BCMO1-deficient mice, comparison of plasma retinol and liver retinyl esters of wild-type, heterozygous and homozygous BCMO1-deficient mice, overview | Mus musculus |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
1.13.11.63 | 63000 | - |
x * 63000, SDS-PAGE | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.13.11.63 | beta-carotene + O2 | Mus musculus | BCMO1 is a key enzyme in the pathway of retinoid synthesis from carotenoids, and is responsible for metabolically limiting the amount of intact beta-carotene that can be absorbed by mice from their diet, regulation of BCMO1 activity, overview | all-trans-retinal | - |
? | |
1.13.11.63 | beta-carotene + O2 | Homo sapiens | BCMO1 is a key enzyme in the pathway of retinoid synthesis from carotenoids, regulation of BCMO1 activity, overview | all-trans-retinal | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.13.11.63 | Homo sapiens | - |
- |
- |
1.13.11.63 | Mus musculus | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.13.11.63 | recombinant His-tagged enzyme from Escherichia coli by nickel affinity chromatography | Homo sapiens |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.13.11.63 | beta-carotene + O2 | - |
Mus musculus | all-trans-retinal | - |
? | |
1.13.11.63 | beta-carotene + O2 | - |
Homo sapiens | all-trans-retinal | - |
? | |
1.13.11.63 | beta-carotene + O2 | BCMO1 is a key enzyme in the pathway of retinoid synthesis from carotenoids, and is responsible for metabolically limiting the amount of intact beta-carotene that can be absorbed by mice from their diet, regulation of BCMO1 activity, overview | Mus musculus | all-trans-retinal | - |
? | |
1.13.11.63 | beta-carotene + O2 | BCMO1 is a key enzyme in the pathway of retinoid synthesis from carotenoids, regulation of BCMO1 activity, overview | Homo sapiens | all-trans-retinal | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
1.13.11.63 | ? | x * 63000, SDS-PAGE | Homo sapiens |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.13.11.63 | Bcmo1 | - |
Mus musculus |
1.13.11.63 | Bcmo1 | - |
Homo sapiens |
1.13.11.63 | beta-carotene-15,15'-monooxygenase | - |
Mus musculus |
1.13.11.63 | beta-carotene-15,15'-monooxygenase | - |
Homo sapiens |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
1.13.11.63 | 37 | - |
assay at | Mus musculus |
1.13.11.63 | 37 | - |
assay at | Homo sapiens |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
1.13.11.63 | 8 | - |
assay at | Mus musculus |
1.13.11.63 | 8 | - |
assay at | Homo sapiens |