Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Steffen, Y.; Gruber, C.; Schewe, T.; Sies, H.
    Mono-O-methylated flavanols and other flavonoids as inhibitors of endothelial NADPH oxidase (2008), Arch. Biochem. Biophys., 469, 209-219.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.6.3.1 (-)-epicatechin glucuronide acts both as a superoxide anion scavenger,and inhibitory to NAD(P)H oxidase, with apocynin-like mode of NADPH oxidase inhibition Homo sapiens
1.6.3.1 3'-(or 4'-)methylluteolin
-
 Homo sapiens
1.6.3.1 3'-O-methyl epicatechin
-
 Homo sapiens
1.6.3.1 4'-O-methyl epicatechin
-
 Homo sapiens
1.6.3.1 COMT-methylated procyanidin B2
-
 Homo sapiens
1.6.3.1 dihydrokaempferol
-
 Homo sapiens
1.6.3.1 dihydrotamarixetin
-
 Homo sapiens
1.6.3.1 diosmetin
-
 Homo sapiens
1.6.3.1 epicatechin gallate
-
 Homo sapiens
1.6.3.1 epigallocatechin
-
 Homo sapiens
1.6.3.1 epigallocatechin gallate
-
 Homo sapiens
1.6.3.1 ferulic acid
-
 Homo sapiens
1.6.3.1 hesperetin
-
 Homo sapiens
1.6.3.1 isorhamnetin
-
 Homo sapiens
1.6.3.1 isorhamnetin glucuronide
-
 Homo sapiens
1.6.3.1 additional information epicatechin is a superoxide anion scavenger, but not inhibitory to NAD(P)H oxidase. HUVEC cells are able to convert (-)-epicatechin to its inhibitory O-methyl esters. IC50-values of (-)epicatechin and (+)catechin are above 0.1 mM in cell lysates Homo sapiens
1.6.3.1 naringenin
-
 Homo sapiens
1.6.3.1 procyanidin B2 acts both as a superoxide anion scavenger, and inhibitory to NAD(P)H oxidase, with apocynin-like mode of NADPH oxidase inhibition Homo sapiens
1.6.3.1 quercetin glucuronide
-
 Homo sapiens
1.6.3.1 tamarixetin
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.6.3.1 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.6.3.1 HUVEC cell
-
 Homo sapiens
-

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.6.3.1 0.0028
-
 25°C, pH 7.4, cell lysate Homo sapiens isorhamnetin
1.6.3.1 0.0035
-
 25°C, pH 7.4, cell lysate Homo sapiens epigallocatechin gallate
1.6.3.1 0.0038
-
 25°C, pH 7.4, cell lysate Homo sapiens procyanidin B2
1.6.3.1 0.0041
-
 25°C, pH 7.4, cell lysate Homo sapiens dihydrotamarixetin
1.6.3.1 0.0045
-
 25°C, pH 7.4, cell lysate Homo sapiens COMT-methylated procyanidin B2
1.6.3.1 0.0049
-
 25°C, pH 7.4, cell lysate Homo sapiens ferulic acid
1.6.3.1 0.0049
-
 25°C, pH 7.4, cell lysate Homo sapiens dihydrokaempferol
1.6.3.1 0.0049
-
 25°C, pH 7.4, cell lysate Homo sapiens (-)-epicatechin glucuronide
1.6.3.1 0.0049
-
 25°C, pH 7.4, cell lysate Homo sapiens quercetin glucuronide
1.6.3.1 0.0049
-
 25°C, pH 7.4, cell lysate Homo sapiens isorhamnetin glucuronide
1.6.3.1 0.0061
-
 25°C, pH 7.4, cell lysate Homo sapiens 3'-(or 4'-)methylluteolin
1.6.3.1 0.0074
-
 25°C, pH 7.4, cell lysate Homo sapiens hesperetin
1.6.3.1 0.0074
-
 25°C, pH 7.4, cell lysate Homo sapiens tamarixetin
1.6.3.1 0.0076
-
 25°C, pH 7.4, cell lysate Homo sapiens diosmetin
1.6.3.1 0.0079
-
 25°C, pH 7.4, cell lysate Homo sapiens naringenin
1.6.3.1 0.0079
-
 25°C, pH 7.4, cell lysate Homo sapiens 3'-O-methyl epicatechin
1.6.3.1 0.008
-
 25°C, pH 7.4, cell lysate Homo sapiens epigallocatechin
1.6.3.1 0.015
-
 25°C, pH 7.4, cell lysate Homo sapiens epicatechin gallate
1.6.3.1 0.0207
-
 25°C, pH 7.4, cell lysate Homo sapiens 4'-O-methyl epicatechin