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Literature summary extracted from

  • Mahesha, H.G.; Singh, S.A.; Rao, A.G.
    Inhibition of lipoxygenase by soy isoflavones: evidence of isoflavones as redox inhibitors (2007), Arch. Biochem. Biophys., 461, 176-185.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.13.11.34 ATP
-
 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.34 daidzein noncompetitive Homo sapiens
1.13.11.34 genistein noncompetitive Homo sapiens
1.13.11.34 additional information isoflavones reduce active state iron to ferrous state and prevent the activation of the resting enzyme, model for the inhibition of lipoxygenase by isoflavones, overview Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.13.11.34 Ca2+ activates Homo sapiens
1.13.11.34 Fe2+ isoflavones reduce active state iron to ferrous state and prevent the activation of the resting enzyme Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.13.11.34 (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate Homo sapiens
-
 leukotriene A4 + H2O
-
 ?
1.13.11.34 arachidonic acid + O2 Homo sapiens
-
 (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.34 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.34 polymorphonuclear cell from peripheral venous blood Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.34 (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
 Homo sapiens leukotriene A4 + H2O
-
 ?
1.13.11.34 arachidonic acid + O2
-
 Homo sapiens (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.13.11.34 5-lipoxygenase
-
 Homo sapiens
1.13.11.34 PMNL 5-lipoxygenase
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.13.11.34 27
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.13.11.34 7.4
-
 assay at Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.13.11.34 0.125
-
 pH 7.4, 27°C Homo sapiens genistein
1.13.11.34 0.157
-
 pH 7.4, 27°C Homo sapiens daidzein