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Literature summary extracted from
- Evolutionary and structural insights into the multifaceted glutathione peroxidase (Gpx) superfamily (2008), Antioxid. Redox Signal., 10, 1501-1514.
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.11.1.9 | cytosol | - |
Homo sapiens | 5829 | - |
| 1.11.1.9 | membrane | GPx-4 | Homo sapiens | 16020 | - |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.11.1.9 | selenium | activity depends on selenium | Homo sapiens |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.11.1.9 | Homo sapiens | O75715 | - |
- |
| 1.11.1.9 | Homo sapiens | P07203 | - |
- |
| 1.11.1.9 | Homo sapiens | P18283 | - |
- |
| 1.11.1.9 | Homo sapiens | P22352 | - |
- |
| 1.11.1.9 | Homo sapiens | P59796 | - |
- |
| 1.11.1.9 | Homo sapiens | Q6PI42 | - |
- |
| 1.11.1.9 | Homo sapiens | Q8TED1 | - |
- |
| 1.11.1.9 | Homo sapiens | Q96SL4 | - |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.11.1.9 | epididymis | Gpx-5 | Homo sapiens | - |
| 1.11.1.9 | gastrointestinal tract | GPx-2 | Homo sapiens | - |
| 1.11.1.9 | olfactory epithelium | GPx-6 | Homo sapiens | - |
| 1.11.1.9 | plasma | GPx-3 | Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.11.1.9 | H2O2 + GSH | - |
Homo sapiens | H2O + GSSG | - |
? | |
| 1.11.1.9 | H2O2 + thioredoxin | - |
Homo sapiens | H2O + ? | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 1.11.1.9 | homodimer | GPx-8 | Homo sapiens |
| 1.11.1.9 | homotetramer | - |
Homo sapiens |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.11.1.9 | Gpx-1 | previously known as cytosolic GPx or cGPx | Homo sapiens |
| 1.11.1.9 | GPx-2 | previously known as GSHPx-GI | Homo sapiens |
| 1.11.1.9 | GPx-3 | previously known as plasma GPx or pGPx | Homo sapiens |
| 1.11.1.9 | GPx-4 | previously known as PHGPx | Homo sapiens |
| 1.11.1.9 | GPx-5 | previously known as epididymal GPx or eGPx | Homo sapiens |
| 1.11.1.9 | GPx-6 | previously named olfactory-metabolizing protein or OMP | Homo sapiens |
| 1.11.1.9 | GPx-7 | the isozyme has only low glutathione peoxidase activity | Homo sapiens |
| 1.11.1.9 | GPx-8 | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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