Literature summary extracted from
Tanomsing, N.; Imwong, M.; Pukrittayakamee, S.; Chotivanich, K.; Looareesuwan, S.; Mayxay, M.; Dolecek, C.; Hien, T.T.; do Rosario, V.E.; Arez, A.P.; Michon, P.; Snounou, G.; White, N.J.; Day, N.P.
Genetic analysis of the dihydrofolate reductase-thymidylate synthase gene from geographically diverse isolates of Plasmodium malariae (2007), Antimicrob. Agents Chemother., 51, 3523-3530.
Protein Variants
EC Number |
Protein Variants |
Comment |
Organism |
---|
1.5.1.3 |
additional information |
survey of polymorphisms in 35 isolates of Plasmodium malariae collected from five countries in Asia and Africa reveals a low copy number of nonsynonymous mutations in five codons |
Plasmodium malariae |
Inhibitors
EC Number |
Inhibitors |
Comment |
Organism |
Structure |
---|
1.5.1.3 |
Chloroquine |
mean 50% inhibitory concentration 74.94 ng/ml in dihydrofolated reductase wild-type from five isolates of Plasmodium malariae collected from five countries in Asia and Africa |
Plasmodium malariae |
|
1.5.1.3 |
pyrimethamine |
mean 50% inhibitory concentration 2.24 ng/ml in dihydrofolated reductase wild-type from five isolates of Plasmodium malariae collected from five countries in Asia and Africa |
Plasmodium malariae |
|
Organism
EC Number |
Organism |
UniProt |
Comment |
Textmining |
---|
1.5.1.3 |
Plasmodium malariae |
- |
bifunctional dihydrofolate reductase/thymidylate synthase |
- |