Literature summary extracted from

Tahar, R.; Basco, L.K.
Molecular epidemiology of malaria in Cameroon. XXV. In vitro activity of fosmidomycin and its derivatives against fresh clinical isolates of Plasmodium falciparum and sequence analysis of 1-deoxy-D-xylulose 5-phosphate reductoisomerase (2007), Am. J. Trop. Med. Hyg., 77, 214-220.

Application

EC Number	Application	Comment	Organism
1.1.1.267	medicine	50% inhibition of growth of parasite in cultured infected erythrocytes is 2-3 times lower with fetal bovine serum in the culture liquide than with human serum	Plasmodium falciparum
1.1.1.267	medicine	study on inhibitory effect of antimalarial drugs in clinical isolates of Plasmodium falciparum. No correlation between chloroquine or pyrimethamine and fosmidomycin. Fosmidomycin is moderately active against both chloroquine-susceptible and chloroquine-resistant isolates	Plasmodium falciparum

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.1.1.267	Chloroquine	-	Plasmodium falciparum
1.1.1.267	fosmidomycin	analysis of parasite growth in infected cultured erythrocytes. 50% growth inhibition at about 301 nM	Plasmodium falciparum
1.1.1.267	FR900098	analysis of parasite growth in infected cultured erythrocytes. 50% growth inhibition at about 118 nM	Plasmodium falciparum
1.1.1.267	pyrimethamine	-	Plasmodium falciparum

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.1.1.267	Plasmodium falciparum	O96693	clinical isolates	-

IC50 Value

EC Number	IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
1.1.1.267	0.000301	-	-	Plasmodium falciparum	fosmidomycin
1.1.1.267	0.118	-	-	Plasmodium falciparum	FR900098

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Release 2023.1 (January 2023)