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Literature summary extracted from

  • Wen, Y.; Gu, J.; Vandenhoff, G.E.; Liu, X.; Nadler, J.L.
    Role of 12/15-lipoxygenase in the expression of MCP-1 in mouse macrophages (2008), Am. J. Physiol. Heart Circ. Physiol., 294, H1933-H1938.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
1.13.11.33 additional information 12/15-LO knockout mice show reduced monocyte chemoattractant protein MCP-1 expression Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.13.11.33 2 arachidonate + 2 O2 + H+ Mus musculus
-
 (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate + (5Z,8Z,11Z,13E)-(15S)-15-hydroxyeicosa-5,8,11,13-tetraenoate + H2O (5Z,8Z,11Z,13E)-(15S)-15-hydroxyeicosa-5,8,11,13-tetraenoate slightly increases expression of monocyte chemoattractant protein MCP-1 in macrophages, also but more potent by 12(S)-hydroxyeicosatetranoic acid, overview ?
1.13.11.33 2 arachidonate + 2 O2 + H+ Mus musculus C57BL/6
-
 (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate + (5Z,8Z,11Z,13E)-(15S)-15-hydroxyeicosa-5,8,11,13-tetraenoate + H2O (5Z,8Z,11Z,13E)-(15S)-15-hydroxyeicosa-5,8,11,13-tetraenoate slightly increases expression of monocyte chemoattractant protein MCP-1 in macrophages, also but more potent by 12(S)-hydroxyeicosatetranoic acid, overview ?

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.31 Mus musculus
-
-
-
1.13.11.31 Sus scrofa
-
-
-
1.13.11.33 Mus musculus
-
 C57BL/6 mice
-
1.13.11.33 Mus musculus C57BL/6
-
 C57BL/6 mice
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.31 additional information Plox-86 cells overexpress leukocyte-type 12/15-LO. Significant increase of monocyte chemoattractant protein-1 mRNA in Plox-86 cells Sus scrofa
-
1.13.11.31 peritoneal macrophage
-
 Mus musculus
-
1.13.11.33 J-774A.1 cell macrophage cell line Mus musculus
-
1.13.11.33 macrophage peritoneal Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.33 2 arachidonate + 2 O2 + H+
-
 Mus musculus (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate + (5Z,8Z,11Z,13E)-(15S)-15-hydroxyeicosa-5,8,11,13-tetraenoate + H2O (5Z,8Z,11Z,13E)-(15S)-15-hydroxyeicosa-5,8,11,13-tetraenoate slightly increases expression of monocyte chemoattractant protein MCP-1 in macrophages, also but more potent by 12(S)-hydroxyeicosatetranoic acid, overview ?
1.13.11.33 2 arachidonate + 2 O2 + H+
-
 Mus musculus (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate + (5Z,8Z,11Z,13E)-(15S)-15-hydroxyeicosa-5,8,11,13-tetraenoate + H2O i.e. 15(S)-HPETE and 15(S)-HETE, the first is the predominant product ?
1.13.11.33 2 arachidonate + 2 O2 + H+
-
 Mus musculus C57BL/6 (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate + (5Z,8Z,11Z,13E)-(15S)-15-hydroxyeicosa-5,8,11,13-tetraenoate + H2O (5Z,8Z,11Z,13E)-(15S)-15-hydroxyeicosa-5,8,11,13-tetraenoate slightly increases expression of monocyte chemoattractant protein MCP-1 in macrophages, also but more potent by 12(S)-hydroxyeicosatetranoic acid, overview ?
1.13.11.33 2 arachidonate + 2 O2 + H+
-
 Mus musculus C57BL/6 (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate + (5Z,8Z,11Z,13E)-(15S)-15-hydroxyeicosa-5,8,11,13-tetraenoate + H2O i.e. 15(S)-HPETE and 15(S)-HETE, the first is the predominant product ?
1.13.11.33 additional information a bifunctional enzyme exhibiting 12-LO and 15-LO activity, the enzyme is also able to catalyze stereoselective oxidation of linoleic acid at position 13 over 9 to preferentially form 13(S)-hydroperoxyoctadienoic acid, which enhances MCP-1 expression, overview Mus musculus ?
-
 ?
1.13.11.33 additional information a bifunctional enzyme exhibiting 12-LO and 15-LO activity, the enzyme is also able to catalyze stereoselective oxidation of linoleic acid at position 13 over 9 to preferentially form 13(S)-hydroperoxyoctadienoic acid, which enhances MCP-1 expression, overview Mus musculus C57BL/6 ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.13.11.31 12/15-lipoxygenase
-
 Mus musculus
1.13.11.31 12/15-lipoxygenase
-
 Sus scrofa
1.13.11.31 12/15-LO
-
 Mus musculus
1.13.11.31 12/15-LO
-
 Sus scrofa
1.13.11.33 12/15-lipoxygenase
-
 Mus musculus
1.13.11.33 12/15-LO
-
 Mus musculus

Expression

EC Number Organism Comment Expression
1.13.11.31 Mus musculus reduced monocyte chemoattractant protein-1 expression in mouse peritoneal macrophages from 12/15-LO null mice down

General Information

EC Number General Information Comment Organism
1.13.11.31 physiological function the 12/15-LO pathway participates in the regulation of monocyte chemoattractant protein-1 expression in mouse macrophages Mus musculus
1.13.11.31 physiological function the 12/15-LO pathway participates in the regulation of monocyte chemoattractant protein-1 expression in mouse macrophages Sus scrofa