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Literature summary extracted from

  • Chawengsub, Y.; Aggarwal, N.T.; Nithipatikom, K.; Gauthier, K.M.; Anjaiah, S.; Hammock, B.D.; Falck, J.R.; Campbell, W.B.
    Identification of 15-hydroxy-11,12-epoxyeicosatrienoic acid as a vasoactive 15-lipoxygenase metabolite in rabbit aorta (2008), Am. J. Physiol. Heart Circ. Physiol., 294, H1348-H1356.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.13.11.33 arachidonate + O2 Oryctolagus cuniculus
-
 (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate is further metabolized by hydroperoxide isomerase to the acid-sensitive metabolite 15(S)-hydroxy-11,12-epoxyeicosatrienoic acid, which is hydrolyzed to 11,12,15-trihydroxyeicosatrienoic acid, by a soluble epoxid hydrolase, causing endothelium-dependent smooth muscle hyperpolarization and relaxations, mass spectrometrical metabolite analysis and pathway, overview ?

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.33 Oryctolagus cuniculus
-
-
-
4.2.1.92 Oryctolagus cuniculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.33 aorta
-
 Oryctolagus cuniculus
-
4.2.1.92 aorta
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.33 arachidonate + O2
-
 Oryctolagus cuniculus (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate
-
 ?
1.13.11.33 arachidonate + O2
-
 Oryctolagus cuniculus (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate is further metabolized by hydroperoxide isomerase to the acid-sensitive metabolite 15(S)-hydroxy-11,12-epoxyeicosatrienoic acid, which is hydrolyzed to 11,12,15-trihydroxyeicosatrienoic acid, by a soluble epoxid hydrolase, causing endothelium-dependent smooth muscle hyperpolarization and relaxations, mass spectrometrical metabolite analysis and pathway, overview ?
4.2.1.92 (15S)-hydroperoxyeicosatetraenoic acid
-
 Oryctolagus cuniculus (15S)-hydroxy-11,12-epoxyeicosatrienoic acid + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.13.11.33 15-lipoxygenase-I
-
 Oryctolagus cuniculus
1.13.11.33 15-LO-I
-
 Oryctolagus cuniculus
4.2.1.92 hydroperoxide isomerase
-
 Oryctolagus cuniculus