Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Torres-Rivera, A.; Landa, A.
    Glutathione transferases from parasites: a biochemical view (2008), Acta Trop., 105, 99-112.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.18 1-Amino-4-{[4-({4-chloro-6-[(2-sulfophenyl)amino]-1,3,5-triazin-2-yl}amino)-3-sulfophenyl]amino}-9,10-dioxo-9,10-dihydro-2-anthracenesulfonic acid
-
Ascaris suum
2.5.1.18 1-Amino-4-{[4-({4-chloro-6-[(2-sulfophenyl)amino]-1,3,5-triazin-2-yl}amino)-3-sulfophenyl]amino}-9,10-dioxo-9,10-dihydro-2-anthracenesulfonic acid
-
Clonorchis sinensis
2.5.1.18 1-Amino-4-{[4-({4-chloro-6-[(2-sulfophenyl)amino]-1,3,5-triazin-2-yl}amino)-3-sulfophenyl]amino}-9,10-dioxo-9,10-dihydro-2-anthracenesulfonic acid
-
Onchocerca volvulus
2.5.1.18 1-Amino-4-{[4-({4-chloro-6-[(2-sulfophenyl)amino]-1,3,5-triazin-2-yl}amino)-3-sulfophenyl]amino}-9,10-dioxo-9,10-dihydro-2-anthracenesulfonic acid
-
Plasmodium falciparum
2.5.1.18 1-Amino-4-{[4-({4-chloro-6-[(2-sulfophenyl)amino]-1,3,5-triazin-2-yl}amino)-3-sulfophenyl]amino}-9,10-dioxo-9,10-dihydro-2-anthracenesulfonic acid
-
Schistosoma japonicum
2.5.1.18 1-Amino-4-{[4-({4-chloro-6-[(2-sulfophenyl)amino]-1,3,5-triazin-2-yl}amino)-3-sulfophenyl]amino}-9,10-dioxo-9,10-dihydro-2-anthracenesulfonic acid
-
Schistosoma mansoni
2.5.1.18 1-Amino-4-{[4-({4-chloro-6-[(2-sulfophenyl)amino]-1,3,5-triazin-2-yl}amino)-3-sulfophenyl]amino}-9,10-dioxo-9,10-dihydro-2-anthracenesulfonic acid
-
Taenia solium
2.5.1.18 albendazole
-
Ascaris suum
2.5.1.18 albendazole
-
Clonorchis sinensis
2.5.1.18 albendazole
-
Schistosoma japonicum
2.5.1.18 albendazole
-
Schistosoma mansoni
2.5.1.18 bilirubin
-
Ascaris suum
2.5.1.18 bilirubin
-
Schistosoma japonicum
2.5.1.18 bilirubin
-
Schistosoma mansoni
2.5.1.18 bithionol
-
Ascaris suum
2.5.1.18 bithionol
-
Schistosoma japonicum
2.5.1.18 bithionol
-
Schistosoma mansoni
2.5.1.18 Bromosulphthalein
-
Ascaris suum
2.5.1.18 Bromosulphthalein
-
Clonorchis sinensis
2.5.1.18 Bromosulphthalein
-
Onchocerca volvulus
2.5.1.18 Bromosulphthalein
-
Schistosoma japonicum
2.5.1.18 Bromosulphthalein
-
Schistosoma mansoni
2.5.1.18 Bromosulphthalein
-
Taenia solium
2.5.1.18 haematin
-
Ancylostoma caninum
2.5.1.18 haematin
-
Onchocerca volvulus
2.5.1.18 haematin
-
Plasmodium falciparum
2.5.1.18 haematin
-
Schistosoma japonicum
2.5.1.18 haematin
-
Schistosoma mansoni
2.5.1.18 Hexachlorophene
-
Ascaris suum
2.5.1.18 Hexachlorophene
-
Schistosoma japonicum
2.5.1.18 Hexachlorophene
-
Schistosoma mansoni
2.5.1.18 protoporphyrin IX
-
Ascaris suum
2.5.1.18 protoporphyrin IX
-
Plasmodium falciparum
2.5.1.18 protoporphyrin IX
-
Schistosoma japonicum
2.5.1.18 protoporphyrin IX
-
Schistosoma mansoni
2.5.1.18 Triphenyltin chloride
-
Ascaris suum
2.5.1.18 Triphenyltin chloride
-
Clonorchis sinensis
2.5.1.18 Triphenyltin chloride
-
Onchocerca volvulus
2.5.1.18 Triphenyltin chloride
-
Schistosoma japonicum
2.5.1.18 Triphenyltin chloride
-
Schistosoma mansoni
2.5.1.18 Triphenyltin chloride
-
Taenia solium

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.5.1.18 0.15
-
1-chloro-2,4-dinitrobenzene
-
Clonorchis sinensis
2.5.1.18 0.16
-
glutathione
-
Plasmodium falciparum
2.5.1.18 0.2
-
glutathione
-
Plasmodium yoelii
2.5.1.18 0.37
-
glutathione
-
Schistosoma mansoni
2.5.1.18 0.43
-
glutathione
-
Schistosoma japonicum
2.5.1.18 0.9
-
glutathione
-
Taenia solium
2.5.1.18 1.28
-
1-chloro-2,4-dinitrobenzene
-
Wuchereria bancrofti
2.5.1.18 2
-
1-chloro-2,4-dinitrobenzene
-
Taenia solium
2.5.1.18 2
-
1-chloro-2,4-dinitrobenzene Km above 2.0 mM Plasmodium falciparum
2.5.1.18 2.67
-
1-chloro-2,4-dinitrobenzene
-
Ascaris suum
2.5.1.18 2.68
-
1-chloro-2,4-dinitrobenzene
-
Schistosoma japonicum
2.5.1.18 2.71
-
1-chloro-2,4-dinitrobenzene
-
Onchocerca volvulus
2.5.1.18 3.3
-
1-chloro-2,4-dinitrobenzene
-
Plasmodium yoelii
2.5.1.18 3.36
-
1-chloro-2,4-dinitrobenzene
-
Schistosoma mansoni

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.5.1.18 cytosol
-
Ascaris suum 5829
-
2.5.1.18 cytosol
-
Schistosoma japonicum 5829
-
2.5.1.18 cytosol
-
Plasmodium falciparum 5829
-
2.5.1.18 cytosol
-
Plasmodium yoelii 5829
-
2.5.1.18 cytosol
-
Rattus norvegicus 5829
-
2.5.1.18 cytosol
-
Mus musculus 5829
-
2.5.1.18 cytosol
-
Sus scrofa 5829
-
2.5.1.18 cytosol
-
Fasciola hepatica 5829
-
2.5.1.18 cytosol
-
Schistosoma mansoni 5829
-
2.5.1.18 cytosol
-
Onchocerca volvulus 5829
-
2.5.1.18 cytosol
-
Wuchereria bancrofti 5829
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.5.1.18 22000
-
2 * 22000 Plasmodium yoelii
2.5.1.18 25000
-
2 * 25000 Plasmodium falciparum
2.5.1.18 25100
-
2 * 25100, gel filtration Clonorchis sinensis
2.5.1.18 26000
-
2 * 26000, gel filtration Schistosoma mansoni
2.5.1.18 26200
-
2 * 26200 Schistosoma japonicum
2.5.1.18 26500
-
2 * 26500, gel filtration Taenia solium
2.5.1.18 30000
-
2 * 30000 Ancylostoma caninum
2.5.1.18 36000
-
2 * 36000 Onchocerca volvulus
2.5.1.18 58500
-
-
Schistosoma japonicum
2.5.1.18 60000
-
SDS-PAGE Taenia solium

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.18 Ancylostoma caninum Q6J1M5
-
-
2.5.1.18 Ascaris suum P46436
-
-
2.5.1.18 Clonorchis sinensis Q1L2C7
-
-
2.5.1.18 Echinococcus granulosus O16058
-
-
2.5.1.18 Fasciola hepatica P56598
-
-
2.5.1.18 Homo sapiens
-
-
-
2.5.1.18 Mus musculus P24472
-
-
2.5.1.18 Onchocerca volvulus P46427
-
-
2.5.1.18 Plasmodium falciparum Q8MU52
-
-
2.5.1.18 Plasmodium yoelii Q7REH6
-
-
2.5.1.18 Rattus norvegicus P04905
-
-
2.5.1.18 Schistosoma japonicum P26624
-
-
2.5.1.18 Schistosoma mansoni P15964
-
-
2.5.1.18 Sus scrofa P80031
-
-
2.5.1.18 Taenia solium Q3ZJN3 fragment
-
2.5.1.18 Wuchereria bancrofti Q86LL8
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.18 glutathione + 1,2-dichloro-4-nitrobenzene
-
Taenia solium ?
-
?
2.5.1.18 glutathione + 1,2-dichloro-4-nitrobenzene
-
Schistosoma mansoni ?
-
?
2.5.1.18 glutathione + 1-chloro-2,4-dinitrobenzene
-
Ancylostoma caninum S-(2,4-dinitrophenyl)glutathione + HCl
-
?
2.5.1.18 glutathione + 1-chloro-2,4-dinitrobenzene
-
Ascaris suum S-(2,4-dinitrophenyl)glutathione + HCl
-
?
2.5.1.18 glutathione + 1-chloro-2,4-dinitrobenzene
-
Schistosoma japonicum S-(2,4-dinitrophenyl)glutathione + HCl
-
?
2.5.1.18 glutathione + 1-chloro-2,4-dinitrobenzene
-
Plasmodium falciparum S-(2,4-dinitrophenyl)glutathione + HCl
-
?
2.5.1.18 glutathione + 1-chloro-2,4-dinitrobenzene
-
Plasmodium yoelii S-(2,4-dinitrophenyl)glutathione + HCl
-
?
2.5.1.18 glutathione + 1-chloro-2,4-dinitrobenzene
-
Taenia solium S-(2,4-dinitrophenyl)glutathione + HCl
-
?
2.5.1.18 glutathione + 1-chloro-2,4-dinitrobenzene
-
Schistosoma mansoni S-(2,4-dinitrophenyl)glutathione + HCl
-
?
2.5.1.18 glutathione + 1-chloro-2,4-dinitrobenzene
-
Onchocerca volvulus S-(2,4-dinitrophenyl)glutathione + HCl
-
?
2.5.1.18 glutathione + 1-chloro-2,4-dinitrobenzene
-
Wuchereria bancrofti S-(2,4-dinitrophenyl)glutathione + HCl
-
?
2.5.1.18 glutathione + 1-chloro-2,4-dinitrobenzene best substrate Fasciola hepatica S-(2,4-dinitrophenyl)glutathione + HCl
-
?
2.5.1.18 glutathione + 1-chloro-2,4-dinitrobenzene best substrate Clonorchis sinensis S-(2,4-dinitrophenyl)glutathione + HCl
-
?
2.5.1.18 glutathione + 4-hydroxynon-2-enal
-
Ascaris suum ?
-
?
2.5.1.18 glutathione + 4-hydroxynon-2-enal
-
Schistosoma japonicum ?
-
?
2.5.1.18 glutathione + 4-hydroxynon-2-enal
-
Schistosoma mansoni ?
-
?
2.5.1.18 glutathione + 4-hydroxynon-2-enal
-
Onchocerca volvulus ?
-
?
2.5.1.18 glutathione + bromosulphthalein
-
Taenia solium ?
-
?
2.5.1.18 glutathione + bromosulphthalein
-
Clonorchis sinensis ?
-
?
2.5.1.18 glutathione + cumene hydroperoxide
-
Ascaris suum ?
-
?
2.5.1.18 glutathione + cumene hydroperoxide
-
Schistosoma japonicum ?
-
?
2.5.1.18 glutathione + cumene hydroperoxide
-
Taenia solium ?
-
?
2.5.1.18 glutathione + cumene hydroperoxide
-
Schistosoma mansoni ?
-
?
2.5.1.18 glutathione + cumene hydroperoxide
-
Onchocerca volvulus ?
-
?
2.5.1.18 glutathione + cumene hydroperoxide
-
Wuchereria bancrofti ?
-
?
2.5.1.18 glutathione + ethacrynic acid
-
Ascaris suum ?
-
?
2.5.1.18 glutathione + ethacrynic acid
-
Schistosoma japonicum ?
-
?
2.5.1.18 glutathione + ethacrynic acid
-
Plasmodium falciparum ?
-
?
2.5.1.18 glutathione + ethacrynic acid
-
Taenia solium ?
-
?
2.5.1.18 glutathione + ethacrynic acid
-
Fasciola hepatica ?
-
?
2.5.1.18 glutathione + ethacrynic acid
-
Clonorchis sinensis ?
-
?
2.5.1.18 glutathione + ethacrynic acid
-
Schistosoma mansoni ?
-
?
2.5.1.18 glutathione + ethacrynic acid
-
Wuchereria bancrofti ?
-
?
2.5.1.18 glutathione + hexa-2,4-dienal
-
Ascaris suum ?
-
?
2.5.1.18 glutathione + hexa-2,4-dienal
-
Schistosoma japonicum ?
-
?
2.5.1.18 glutathione + hexa-2,4-dienal
-
Taenia solium ?
-
?
2.5.1.18 glutathione + hexa-2,4-dienal
-
Clonorchis sinensis ?
-
?
2.5.1.18 glutathione + hexa-2,4-dienal
-
Schistosoma mansoni ?
-
?
2.5.1.18 glutathione + hexa-2,4-dienal
-
Onchocerca volvulus ?
-
?
2.5.1.18 glutathione + trans-2-nonenal
-
Ascaris suum ?
-
?
2.5.1.18 glutathione + trans-2-nonenal
-
Schistosoma japonicum ?
-
?
2.5.1.18 glutathione + trans-2-nonenal
-
Taenia solium ?
-
?
2.5.1.18 glutathione + trans-2-nonenal
-
Fasciola hepatica ?
-
?
2.5.1.18 glutathione + trans-2-nonenal
-
Clonorchis sinensis ?
-
?
2.5.1.18 glutathione + trans-2-nonenal
-
Schistosoma mansoni ?
-
?
2.5.1.18 glutathione + trans-2-nonenal
-
Onchocerca volvulus ?
-
?
2.5.1.18 glutathione + trans-2-nonenal
-
Wuchereria bancrofti ?
-
?
2.5.1.18 glutathione + trans-4-phenyl-3-buten-2-one
-
Schistosoma japonicum ?
-
?
2.5.1.18 glutathione + trans-4-phenyl-3-buten-2-one
-
Taenia solium ?
-
?
2.5.1.18 glutathione + trans-4-phenyl-3-buten-2-one
-
Fasciola hepatica ?
-
?
2.5.1.18 glutathione + trans-4-phenyl-3-buten-2-one
-
Clonorchis sinensis ?
-
?
2.5.1.18 glutathione + trans-4-phenyl-3-buten-2-one
-
Schistosoma mansoni ?
-
?
2.5.1.18 glutathione + trans-trans-2,4-decadienal
-
Ascaris suum ?
-
?
2.5.1.18 glutathione + trans-trans-2,4-decadienal
-
Schistosoma japonicum ?
-
?
2.5.1.18 glutathione + trans-trans-2,4-decadienal
-
Fasciola hepatica ?
-
?
2.5.1.18 glutathione + trans-trans-2,4-decadienal
-
Schistosoma mansoni ?
-
?
2.5.1.18 glutathione + trans-trans-2,4-decadienal
-
Onchocerca volvulus ?
-
?
2.5.1.18 additional information 1,2-dichloro-4-nitrobenzene and 1,2-epoxy-3-(4-nitrophenoxy) propane are no substrates Clonorchis sinensis ?
-
?
2.5.1.18 additional information 1,2-epoxy-3-(4-nitrophenoxy) propane is no substrate Fasciola hepatica ?
-
?
2.5.1.18 additional information bromosulphthalein and 1,2-epoxy-3-(4-nitrophenoxy) propane are no substrates Schistosoma mansoni ?
-
?
2.5.1.18 additional information no detectable activity with 1,2-dichloro-4-nitrobenzene, bromosulphthalein, and 1,2-epoxy-3-(4-nitrophenoxy) propane Ascaris suum ?
-
?
2.5.1.18 additional information no detectable activity with 1,2-dichloro-4-nitrobenzene, bromosulphthalein, and 1,2-epoxy-3-(4-nitrophenoxy) propane Schistosoma japonicum ?
-
?
2.5.1.18 additional information no detectable activity with 1,2-dichloro-4-nitrobenzene, ethacrynic acid, bromosulphthalein, and 1,2-epoxy-3-(4-nitrophenoxy) propane Onchocerca volvulus ?
-
?
2.5.1.18 additional information no detectable activity with 1,2-dichloro-4-nitrobenzene, hexa-2,4-dienal, and bromosulphthalein Wuchereria bancrofti ?
-
?
2.5.1.18 additional information no detectable activity with 1,2-epoxy-3-(4-nitrophenoxy) propane Taenia solium ?
-
?

Subunits

EC Number Subunits Comment Organism
2.5.1.18 dimer
-
Homo sapiens
2.5.1.18 dimer
-
Ascaris suum
2.5.1.18 dimer
-
Rattus norvegicus
2.5.1.18 dimer
-
Mus musculus
2.5.1.18 dimer
-
Sus scrofa
2.5.1.18 dimer
-
Fasciola hepatica
2.5.1.18 dimer
-
Echinococcus granulosus
2.5.1.18 dimer
-
Wuchereria bancrofti
2.5.1.18 dimer 2 * 26000, gel filtration Schistosoma mansoni
2.5.1.18 homodimer 2 * 25000 Plasmodium falciparum
2.5.1.18 homodimer 2 * 30000 Ancylostoma caninum
2.5.1.18 homodimer 2 * 22000 Plasmodium yoelii
2.5.1.18 homodimer 2 * 36000 Onchocerca volvulus
2.5.1.18 homodimer 2 * 25100, gel filtration Clonorchis sinensis
2.5.1.18 homodimer 2 * 26200 Schistosoma japonicum
2.5.1.18 homodimer 2 * 26500, gel filtration Taenia solium

Synonyms

EC Number Synonyms Comment Organism
2.5.1.18 glutathione S-transferase
-
Homo sapiens
2.5.1.18 glutathione S-transferase
-
Ancylostoma caninum
2.5.1.18 glutathione S-transferase
-
Ascaris suum
2.5.1.18 glutathione S-transferase
-
Schistosoma japonicum
2.5.1.18 glutathione S-transferase
-
Plasmodium falciparum
2.5.1.18 glutathione S-transferase
-
Plasmodium yoelii
2.5.1.18 glutathione S-transferase
-
Rattus norvegicus
2.5.1.18 glutathione S-transferase
-
Mus musculus
2.5.1.18 glutathione S-transferase
-
Sus scrofa
2.5.1.18 glutathione S-transferase
-
Taenia solium
2.5.1.18 glutathione S-transferase
-
Fasciola hepatica
2.5.1.18 glutathione S-transferase
-
Clonorchis sinensis
2.5.1.18 glutathione S-transferase
-
Schistosoma mansoni
2.5.1.18 glutathione S-transferase
-
Echinococcus granulosus
2.5.1.18 glutathione S-transferase
-
Onchocerca volvulus
2.5.1.18 glutathione S-transferase
-
Wuchereria bancrofti
2.5.1.18 GST
-
Homo sapiens
2.5.1.18 GST
-
Ancylostoma caninum
2.5.1.18 GST
-
Ascaris suum
2.5.1.18 GST
-
Schistosoma japonicum
2.5.1.18 GST
-
Plasmodium falciparum
2.5.1.18 GST
-
Plasmodium yoelii
2.5.1.18 GST
-
Rattus norvegicus
2.5.1.18 GST
-
Mus musculus
2.5.1.18 GST
-
Sus scrofa
2.5.1.18 GST
-
Taenia solium
2.5.1.18 GST
-
Fasciola hepatica
2.5.1.18 GST
-
Clonorchis sinensis
2.5.1.18 GST
-
Schistosoma mansoni
2.5.1.18 GST
-
Echinococcus granulosus
2.5.1.18 GST
-
Onchocerca volvulus
2.5.1.18 GST
-
Wuchereria bancrofti

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.5.1.18 0.0005
-
Cibacron blue 3GA
-
Plasmodium falciparum
2.5.1.18 0.01
-
protoporphyrin IX
-
Plasmodium falciparum
2.5.1.18 0.01
-
haematin
-
Plasmodium falciparum

pI Value

EC Number Organism Comment pI Value Maximum pI Value
2.5.1.18 Schistosoma japonicum isoelectric focusing
-
5
2.5.1.18 Clonorchis sinensis isoelectric focusing
-
6.1
2.5.1.18 Taenia solium isoelectric focusing
-
7.1
2.5.1.18 Schistosoma mansoni isoelectric focusing
-
7.4

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.5.1.18 0.00003
-
-
Onchocerca volvulus Cibacron blue 3GA
2.5.1.18 0.00005
-
-
Onchocerca volvulus Triphenyltin chloride
2.5.1.18 0.00007
-
-
Clonorchis sinensis Cibacron blue 3GA
2.5.1.18 0.00009
-
-
Ascaris suum Cibacron blue 3GA
2.5.1.18 0.0003
-
-
Ascaris suum Triphenyltin chloride
2.5.1.18 0.00034
-
-
Ascaris suum Hexachlorophene
2.5.1.18 0.00047
-
-
Schistosoma japonicum Triphenyltin chloride
2.5.1.18 0.00055
-
-
Onchocerca volvulus haematin
2.5.1.18 0.00059
-
-
Schistosoma japonicum Hexachlorophene
2.5.1.18 0.00068
-
-
Taenia solium Bromosulphthalein
2.5.1.18 0.00069
-
-
Schistosoma japonicum Cibacron blue 3GA
2.5.1.18 0.00071
-
-
Taenia solium Cibacron blue 3GA
2.5.1.18 0.00075
-
-
Onchocerca volvulus Bromosulphthalein
2.5.1.18 0.001
-
-
Ascaris suum Bromosulphthalein
2.5.1.18 0.00109
-
-
Clonorchis sinensis Bromosulphthalein
2.5.1.18 0.00172
-
-
Clonorchis sinensis Triphenyltin chloride
2.5.1.18 0.00323
-
-
Ancylostoma caninum haematin
2.5.1.18 0.0041
-
-
Schistosoma japonicum haematin
2.5.1.18 0.00632
-
-
Taenia solium Triphenyltin chloride
2.5.1.18 0.0077
-
-
Ascaris suum bithionol
2.5.1.18 0.009
-
-
Ascaris suum bilirubin
2.5.1.18 0.0134
-
-
Schistosoma japonicum bithionol
2.5.1.18 0.0275
-
-
Clonorchis sinensis albendazole
2.5.1.18 0.03
-
-
Ascaris suum protoporphyrin IX
2.5.1.18 0.0364
-
-
Schistosoma japonicum Bromosulphthalein
2.5.1.18 0.116
-
-
Schistosoma japonicum protoporphyrin IX
2.5.1.18 0.25
-
-
Schistosoma japonicum albendazole
2.5.1.18 0.442
-
-
Schistosoma japonicum bilirubin
2.5.1.18 0.52
-
-
Ascaris suum albendazole