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Literature summary extracted from
- On the role of prolyl oligopeptidase in health and disease (2007), Neuropeptides, 41, 1-24.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.21.26 | 2-mercaptoethanol | activation of the cytsolic isozyme, but not of the extracellular isozyme | Homo sapiens |  |
| 3.4.21.26 | DTT | activation of the cytsolic isozyme, but not of the extracellular isozyme | Homo sapiens | |
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 3.4.21.26 | gene prep, mapping to chromosome 10B2-B3, DNA and amino acid sequence analysis, expression analysis | Mus musculus |
| 3.4.21.26 | gene prep, mapping to chromosome 6q22, expression analysis | Homo sapiens |
Crystallization (Commentary)
| EC Number | Crystallization (Comment) | Organism |
|---|---|---|
| 3.4.21.26 | enzyme in complex with inhibitor benzyloxycarbonyl-Pro-Prolinal, X-ray diffraction structure determination at high resolution | Sus scrofa |
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 3.4.21.26 | additional information | a mutant deficient for the dpoA gene is resistant to the effects of lithium | Flavobacterium sp. |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.21.26 | 4-(2-aminoethyl)benzenesulfonyl fluoride | inhibition of extracellular isozyme | Homo sapiens | |
| 3.4.21.26 | Aprotinin | inhibition of extracellular isozyme | Homo sapiens | |
| 3.4.21.26 | benzyloxycarbonyl-Pro-prolinal | i.e. Z-Pro-prolinal | Dictyostelium discoideum | |
| 3.4.21.26 | benzyloxycarbonyl-Pro-prolinal | i.e. Z-Pro-prolinal | Flavobacterium sp. | |
| 3.4.21.26 | benzyloxycarbonyl-Pro-prolinal | i.e. Z-Pro-Prolinal, inhibition of cytsolic isozyme, but no inhibition of the extracellular isozyme in serum | Homo sapiens | |
| 3.4.21.26 | benzyloxycarbonyl-Pro-prolinal | i.e. Z-Pro-prolinal | Mus musculus | |
| 3.4.21.26 | benzyloxycarbonyl-Pro-prolinal | i.e. Z-Pro-prolinal | Novosphingobium capsulatum | |
| 3.4.21.26 | benzyloxycarbonyl-Pro-prolinal | i.e. Z-Pro-prolinal | Rattus norvegicus | |
| 3.4.21.26 | benzyloxycarbonyl-Pro-prolinal | i.e. Z-Pro-prolinal | Sus scrofa | |
| 3.4.21.26 | JTP-4819 | - |
Dictyostelium discoideum | |
| 3.4.21.26 | JTP-4819 | - |
Flavobacterium sp. | |
| 3.4.21.26 | JTP-4819 | - |
Homo sapiens | |
| 3.4.21.26 | JTP-4819 | - |
Mus musculus | |
| 3.4.21.26 | JTP-4819 | - |
Novosphingobium capsulatum | |
| 3.4.21.26 | JTP-4819 | - |
Rattus norvegicus | |
| 3.4.21.26 | JTP-4819 | - |
Sus scrofa | |
| 3.4.21.26 | additional information | structure-function relationship of inhibitors, specificity at the P2 and S3 position, overview | Dictyostelium discoideum | |
| 3.4.21.26 | additional information | structure-function relationship of inhibitors, specificity at the P2 and S3 position, overview | Flavobacterium sp. | |
| 3.4.21.26 | additional information | structure-function relationship of inhibitors, specificity at the P2 and S3 position, overview | Homo sapiens | |
| 3.4.21.26 | additional information | structure-function relationship of inhibitors, specificity at the P2 and S3 position, overview | Mus musculus | |
| 3.4.21.26 | additional information | structure-function relationship of inhibitors, specificity at the P2 and S3 position, overview | Novosphingobium capsulatum | |
| 3.4.21.26 | additional information | structure-function relationship of inhibitors, specificity at the P2 and S3 position, overview | Rattus norvegicus | |
| 3.4.21.26 | additional information | structure-function relationship of inhibitors, specificity at the P2 and S3 position, overview | Sus scrofa | |
| 3.4.21.26 | ONO-1603 | - |
Dictyostelium discoideum | |
| 3.4.21.26 | ONO-1603 | - |
Flavobacterium sp. | |
| 3.4.21.26 | ONO-1603 | - |
Homo sapiens | |
| 3.4.21.26 | ONO-1603 | - |
Mus musculus | |
| 3.4.21.26 | ONO-1603 | - |
Novosphingobium capsulatum | |
| 3.4.21.26 | ONO-1603 | - |
Rattus norvegicus | |
| 3.4.21.26 | ONO-1603 | - |
Sus scrofa | |
| 3.4.21.26 | S-17092 | - |
Dictyostelium discoideum | |
| 3.4.21.26 | S-17092 | - |
Flavobacterium sp. | |
| 3.4.21.26 | S-17092 | - |
Homo sapiens | |
| 3.4.21.26 | S-17092 | - |
Mus musculus | |
| 3.4.21.26 | S-17092 | - |
Novosphingobium capsulatum | |
| 3.4.21.26 | S-17092 | - |
Rattus norvegicus | |
| 3.4.21.26 | S-17092 | - |
Sus scrofa | |
| 3.4.21.26 | SUAM-1221 | - |
Dictyostelium discoideum | |
| 3.4.21.26 | SUAM-1221 | - |
Flavobacterium sp. | |
| 3.4.21.26 | SUAM-1221 | - |
Homo sapiens | |
| 3.4.21.26 | SUAM-1221 | - |
Mus musculus | |
| 3.4.21.26 | SUAM-1221 | - |
Novosphingobium capsulatum | |
| 3.4.21.26 | SUAM-1221 | - |
Rattus norvegicus | |
| 3.4.21.26 | SUAM-1221 | - |
Sus scrofa | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.4.21.26 | cytoplasm | - |
Mus musculus | 5737 | - |
| 3.4.21.26 | cytosol | - |
Homo sapiens | 5829 | - |
| 3.4.21.26 | cytosol | - |
Rattus norvegicus | 5829 | - |
| 3.4.21.26 | extracellular | - |
Homo sapiens | - |
- |
| 3.4.21.26 | extracellular | - |
Dictyostelium discoideum | - |
- |
| 3.4.21.26 | extracellular | - |
Flavobacterium sp. | - |
- |
| 3.4.21.26 | extracellular | - |
Novosphingobium capsulatum | - |
- |
| 3.4.21.26 | membrane | - |
Dictyostelium discoideum | 16020 | - |
| 3.4.21.26 | membrane | - |
Flavobacterium sp. | 16020 | - |
| 3.4.21.26 | membrane | - |
Novosphingobium capsulatum | 16020 | - |
| 3.4.21.26 | membrane | isoyzme in brain synaptosome membranes | Rattus norvegicus | 16020 | - |
| 3.4.21.26 | synaptosome | - |
Rattus norvegicus | - |
- |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.4.21.26 | 80000 | - |
x * 80000, about | Mus musculus |
| 3.4.21.26 | 87000 | - |
x * 87000, extracellular isozyme, SDS-PAGE | Homo sapiens |
| 3.4.21.26 | 170000 | - |
cytosolic isozyme | Homo sapiens |
| 3.4.21.26 | 174000 | - |
extracellular isozyme | Homo sapiens |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.26 | alpha-melanocyte-stimulating hormone + H2O | Mus musculus | - |
? | - |
? | |
| 3.4.21.26 | alpha-melanocyte-stimulating hormone + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.21.26 | alpha-melanocyte-stimulating hormone + H2O | Rattus norvegicus | - |
? | - |
? | |
| 3.4.21.26 | alpha-melanocyte-stimulating hormone + H2O | Sus scrofa | - |
? | - |
? | |
| 3.4.21.26 | angiotensin I + H2O | Mus musculus | - |
? | - |
? | |
| 3.4.21.26 | angiotensin I + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.21.26 | angiotensin I + H2O | Rattus norvegicus | - |
? | - |
? | |
| 3.4.21.26 | angiotensin I + H2O | Sus scrofa | - |
? | - |
? | |
| 3.4.21.26 | angiotensin II + H2O | Mus musculus | - |
? | - |
? | |
| 3.4.21.26 | angiotensin II + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.21.26 | angiotensin II + H2O | Rattus norvegicus | - |
? | - |
? | |
| 3.4.21.26 | angiotensin II + H2O | Sus scrofa | - |
? | - |
? | |
| 3.4.21.26 | arginine-vasopressin + H2O | Mus musculus | - |
? | - |
? | |
| 3.4.21.26 | arginine-vasopressin + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.21.26 | arginine-vasopressin + H2O | Rattus norvegicus | - |
? | - |
? | |
| 3.4.21.26 | arginine-vasopressin + H2O | Sus scrofa | - |
? | - |
? | |
| 3.4.21.26 | beta-endorphin + H2O | Mus musculus | - |
? | - |
? | |
| 3.4.21.26 | beta-endorphin + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.21.26 | beta-endorphin + H2O | Rattus norvegicus | - |
? | - |
? | |
| 3.4.21.26 | beta-endorphin + H2O | Sus scrofa | - |
? | - |
? | |
| 3.4.21.26 | bradykinin + H2O | Mus musculus | - |
? | - |
? | |
| 3.4.21.26 | bradykinin + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.21.26 | bradykinin + H2O | Rattus norvegicus | - |
? | - |
? | |
| 3.4.21.26 | bradykinin + H2O | Sus scrofa | - |
? | - |
? | |
| 3.4.21.26 | gonadotropin releasing hormone + H2O | Mus musculus | - |
? | - |
? | |
| 3.4.21.26 | gonadotropin releasing hormone + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.21.26 | gonadotropin releasing hormone + H2O | Rattus norvegicus | - |
? | - |
? | |
| 3.4.21.26 | gonadotropin releasing hormone + H2O | Sus scrofa | - |
? | - |
? | |
| 3.4.21.26 | additional information | Novosphingobium capsulatum | enzyme regulation, overview | ? | - |
? | |
| 3.4.21.26 | additional information | Dictyostelium discoideum | enzyme inhibition leads to inhibition of lithium effects, the loss of enzyme activity evokes a 4fold increase in the inositol-3-phosphate concentration counteracting the Li+ ions, enzyme regulation, overview | ? | - |
? | |
| 3.4.21.26 | additional information | Homo sapiens | the enzyme is a serine protease, that digests small peptide-like hormones, neuroactive peptides, and various cellular factors, it is implicated in several biological processes and diseases, e.g. in some psychiatric disorders, most probably through interference in the inositol cycle, it is important in the metabolism of substance P, arginine vasopressin, thyroliberin, and gonadoliberin, enzyme regulation probably involving gluten, prep expression is downregulated in coelic disease patients in complete remission, overview | ? | - |
? | |
| 3.4.21.26 | additional information | Mus musculus | the enzyme is a serine protease, that digests small peptide-like hormones, neuroactive peptides, and various cellular factors, it is implicated in several biological processes and diseases, e.g. in some psychiatric disorders, most probably through interference in the inositol cycle, it is important in the metabolism of substance P, arginine vasopressin, thyroliberin, and gonadoliberin, enzyme regulation, overview | ? | - |
? | |
| 3.4.21.26 | additional information | Rattus norvegicus | the enzyme is a serine protease, that digests small peptide-like hormones, neuroactive peptides, and various cellular factors, it is implicated in several biological processes and diseases, e.g. in some psychiatric disorders, most probably through interference in the inositol cycle, it is important in the metabolism of substance P, arginine vasopressin, thyroliberin, and gonadoliberin, enzyme regulation, overview | ? | - |
? | |
| 3.4.21.26 | additional information | Sus scrofa | the enzyme is a serine protease, that digests small peptide-like hormones, neuroactive peptides, and various cellular factors, it is implicated in several biological processes and diseases, e.g. in some psychiatric disorders, most probably through interference in the inositol cycle, it is important in the metabolism of substance P, arginine vasopressin, thyroliberin, and gonadoliberin, enzyme regulation, overview | ? | - |
? | |
| 3.4.21.26 | additional information | Flavobacterium sp. | the enzyme removes most of the gut-digestion-resistant gliadin peptides in the host gut luman of coeliac disease patients, overview, enzyme regulation, overview | ? | - |
? | |
| 3.4.21.26 | neurotensin + H2O | Mus musculus | - |
? | - |
? | |
| 3.4.21.26 | neurotensin + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.21.26 | neurotensin + H2O | Rattus norvegicus | - |
? | - |
? | |
| 3.4.21.26 | neurotensin + H2O | Sus scrofa | - |
? | - |
? | |
| 3.4.21.26 | oxytoxin + H2O | Mus musculus | - |
? | - |
? | |
| 3.4.21.26 | oxytoxin + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.21.26 | oxytoxin + H2O | Rattus norvegicus | - |
? | - |
? | |
| 3.4.21.26 | oxytoxin + H2O | Sus scrofa | - |
? | - |
? | |
| 3.4.21.26 | Substance P + H2O | Mus musculus | - |
? | - |
? | |
| 3.4.21.26 | Substance P + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.21.26 | Substance P + H2O | Rattus norvegicus | - |
? | - |
? | |
| 3.4.21.26 | Substance P + H2O | Sus scrofa | - |
? | - |
? | |
| 3.4.21.26 | thyrotropin releasing hormone + H2O | Mus musculus | - |
? | - |
? | |
| 3.4.21.26 | thyrotropin releasing hormone + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.21.26 | thyrotropin releasing hormone + H2O | Rattus norvegicus | - |
? | - |
? | |
| 3.4.21.26 | thyrotropin releasing hormone + H2O | Sus scrofa | - |
? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.21.26 | Dictyostelium discoideum | - |
- |
- |
| 3.4.21.26 | Flavobacterium sp. | - |
- |
- |
| 3.4.21.26 | Homo sapiens | - |
gene prep | - |
| 3.4.21.26 | Mus musculus | - |
gene prep | - |
| 3.4.21.26 | Novosphingobium capsulatum | - |
- |
- |
| 3.4.21.26 | Rattus norvegicus | - |
- |
- |
| 3.4.21.26 | Sus scrofa | P23687 | - |
- |
Posttranslational Modification
| EC Number | Posttranslational Modification | Comment | Organism |
|---|---|---|---|
| 3.4.21.26 | no modification | - |
Mus musculus |
| 3.4.21.26 | no modification | - |
Homo sapiens |
| 3.4.21.26 | no modification | - |
Rattus norvegicus |
| 3.4.21.26 | no modification | - |
Sus scrofa |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.4.21.26 | extracellular isozyme, cytsolic isozyme, overview | Homo sapiens |
Reaction
| EC Number | Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|---|
| 3.4.21.26 | Hydrolysis of --Pro-/- and to a lesser extent --Ala-/- in oligopeptides | catalytic mechanism, structure-function relationship | Mus musculus | |
| 3.4.21.26 | Hydrolysis of --Pro-/- and to a lesser extent --Ala-/- in oligopeptides | catalytic mechanism, structure-function relationship | Homo sapiens | |
| 3.4.21.26 | Hydrolysis of --Pro-/- and to a lesser extent --Ala-/- in oligopeptides | catalytic mechanism, structure-function relationship | Rattus norvegicus | |
| 3.4.21.26 | Hydrolysis of --Pro-/- and to a lesser extent --Ala-/- in oligopeptides | catalytic mechanism, structure-function relationship | Dictyostelium discoideum | |
| 3.4.21.26 | Hydrolysis of --Pro-/- and to a lesser extent --Ala-/- in oligopeptides | catalytic mechanism, structure-function relationship | Flavobacterium sp. | |
| 3.4.21.26 | Hydrolysis of --Pro-/- and to a lesser extent --Ala-/- in oligopeptides | catalytic mechanism, structure-function relationship | Sus scrofa | |
| 3.4.21.26 | Hydrolysis of --Pro-/- and to a lesser extent --Ala-/- in oligopeptides | catalytic mechanism, structure-function relationship, the substrate induces an opening at the interface pf the peptidase and the beta-propeller domains while entering into the active site, concerted movements of the domains are required for enzyme activity | Novosphingobium capsulatum |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.21.26 | amygdala | - |
Mus musculus | - |
| 3.4.21.26 | amygdala | - |
Homo sapiens | - |
| 3.4.21.26 | amygdala | - |
Rattus norvegicus | - |
| 3.4.21.26 | blood | - |
Homo sapiens | - |
| 3.4.21.26 | brain | - |
Mus musculus | - |
| 3.4.21.26 | brain | high enzyme content | Rattus norvegicus | - |
| 3.4.21.26 | brain cortex | - |
Mus musculus | - |
| 3.4.21.26 | brain cortex | - |
Homo sapiens | - |
| 3.4.21.26 | brain cortex | - |
Rattus norvegicus | - |
| 3.4.21.26 | central nervous system | distribution, overview | Mus musculus | - |
| 3.4.21.26 | central nervous system | distribution, overview | Homo sapiens | - |
| 3.4.21.26 | central nervous system | distribution, overview | Rattus norvegicus | - |
| 3.4.21.26 | cerebellum | - |
Mus musculus | - |
| 3.4.21.26 | cerebellum | - |
Homo sapiens | - |
| 3.4.21.26 | cerebellum | - |
Rattus norvegicus | - |
| 3.4.21.26 | endothelial cell | - |
Homo sapiens | - |
| 3.4.21.26 | epithelial cell | - |
Homo sapiens | - |
| 3.4.21.26 | fibroblast | - |
Homo sapiens | - |
| 3.4.21.26 | heart | - |
Homo sapiens | - |
| 3.4.21.26 | heart | - |
Rattus norvegicus | - |
| 3.4.21.26 | hippocampus | - |
Mus musculus | - |
| 3.4.21.26 | hippocampus | - |
Homo sapiens | - |
| 3.4.21.26 | hippocampus | - |
Rattus norvegicus | - |
| 3.4.21.26 | hypothalamus | - |
Mus musculus | - |
| 3.4.21.26 | hypothalamus | - |
Homo sapiens | - |
| 3.4.21.26 | hypothalamus | - |
Rattus norvegicus | - |
| 3.4.21.26 | kidney | - |
Rattus norvegicus | - |
| 3.4.21.26 | liver | - |
Rattus norvegicus | - |
| 3.4.21.26 | lung | - |
Homo sapiens | - |
| 3.4.21.26 | lung | - |
Rattus norvegicus | - |
| 3.4.21.26 | lung cancer cell | high enzyme content | Homo sapiens | - |
| 3.4.21.26 | lymphocyte | - |
Homo sapiens | - |
| 3.4.21.26 | pituitary gland | - |
Rattus norvegicus | - |
| 3.4.21.26 | platelet | - |
Homo sapiens | - |
| 3.4.21.26 | prostate cancer cell | high enzyme content | Homo sapiens | - |
| 3.4.21.26 | prostate fluid | - |
Homo sapiens | - |
| 3.4.21.26 | rectum | - |
Homo sapiens | - |
| 3.4.21.26 | renal cortex | - |
Homo sapiens | - |
| 3.4.21.26 | seminal fluid | - |
Homo sapiens | - |
| 3.4.21.26 | spleen | - |
Homo sapiens | - |
| 3.4.21.26 | spleen | - |
Rattus norvegicus | - |
| 3.4.21.26 | striatum | - |
Mus musculus | - |
| 3.4.21.26 | striatum | - |
Homo sapiens | - |
| 3.4.21.26 | striatum | - |
Rattus norvegicus | - |
| 3.4.21.26 | testis | - |
Homo sapiens | - |
| 3.4.21.26 | uterus | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.26 | alpha-melanocyte-stimulating hormone + H2O | - |
Mus musculus | ? | - |
? | |
| 3.4.21.26 | alpha-melanocyte-stimulating hormone + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.26 | alpha-melanocyte-stimulating hormone + H2O | - |
Rattus norvegicus | ? | - |
? | |
| 3.4.21.26 | alpha-melanocyte-stimulating hormone + H2O | - |
Sus scrofa | ? | - |
? | |
| 3.4.21.26 | angiotensin I + H2O | - |
Mus musculus | ? | - |
? | |
| 3.4.21.26 | angiotensin I + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.26 | angiotensin I + H2O | - |
Rattus norvegicus | ? | - |
? | |
| 3.4.21.26 | angiotensin I + H2O | - |
Sus scrofa | ? | - |
? | |
| 3.4.21.26 | angiotensin II + H2O | - |
Mus musculus | ? | - |
? | |
| 3.4.21.26 | angiotensin II + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.26 | angiotensin II + H2O | - |
Rattus norvegicus | ? | - |
? | |
| 3.4.21.26 | angiotensin II + H2O | - |
Sus scrofa | ? | - |
? | |
| 3.4.21.26 | arginine-vasopressin + H2O | - |
Mus musculus | ? | - |
? | |
| 3.4.21.26 | arginine-vasopressin + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.26 | arginine-vasopressin + H2O | - |
Rattus norvegicus | ? | - |
? | |
| 3.4.21.26 | arginine-vasopressin + H2O | - |
Sus scrofa | ? | - |
? | |
| 3.4.21.26 | beta-endorphin + H2O | - |
Mus musculus | ? | - |
? | |
| 3.4.21.26 | beta-endorphin + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.26 | beta-endorphin + H2O | - |
Rattus norvegicus | ? | - |
? | |
| 3.4.21.26 | beta-endorphin + H2O | - |
Sus scrofa | ? | - |
? | |
| 3.4.21.26 | bradykinin + H2O | - |
Mus musculus | ? | - |
? | |
| 3.4.21.26 | bradykinin + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.26 | bradykinin + H2O | - |
Rattus norvegicus | ? | - |
? | |
| 3.4.21.26 | bradykinin + H2O | - |
Sus scrofa | ? | - |
? | |
| 3.4.21.26 | gonadotropin releasing hormone + H2O | - |
Mus musculus | ? | - |
? | |
| 3.4.21.26 | gonadotropin releasing hormone + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.26 | gonadotropin releasing hormone + H2O | - |
Rattus norvegicus | ? | - |
? | |
| 3.4.21.26 | gonadotropin releasing hormone + H2O | - |
Sus scrofa | ? | - |
? | |
| 3.4.21.26 | additional information | enzyme regulation, overview | Novosphingobium capsulatum | ? | - |
? | |
| 3.4.21.26 | additional information | enzyme inhibition leads to inhibition of lithium effects, the loss of enzyme activity evokes a 4fold increase in the inositol-3-phosphate concentration counteracting the Li+ ions, enzyme regulation, overview | Dictyostelium discoideum | ? | - |
? | |
| 3.4.21.26 | additional information | the enzyme is a serine protease, that digests small peptide-like hormones, neuroactive peptides, and various cellular factors, it is implicated in several biological processes and diseases, e.g. in some psychiatric disorders, most probably through interference in the inositol cycle, it is important in the metabolism of substance P, arginine vasopressin, thyroliberin, and gonadoliberin, enzyme regulation probably involving gluten, prep expression is downregulated in coelic disease patients in complete remission, overview | Homo sapiens | ? | - |
? | |
| 3.4.21.26 | additional information | the enzyme is a serine protease, that digests small peptide-like hormones, neuroactive peptides, and various cellular factors, it is implicated in several biological processes and diseases, e.g. in some psychiatric disorders, most probably through interference in the inositol cycle, it is important in the metabolism of substance P, arginine vasopressin, thyroliberin, and gonadoliberin, enzyme regulation, overview | Mus musculus | ? | - |
? | |
| 3.4.21.26 | additional information | the enzyme is a serine protease, that digests small peptide-like hormones, neuroactive peptides, and various cellular factors, it is implicated in several biological processes and diseases, e.g. in some psychiatric disorders, most probably through interference in the inositol cycle, it is important in the metabolism of substance P, arginine vasopressin, thyroliberin, and gonadoliberin, enzyme regulation, overview | Rattus norvegicus | ? | - |
? | |
| 3.4.21.26 | additional information | the enzyme is a serine protease, that digests small peptide-like hormones, neuroactive peptides, and various cellular factors, it is implicated in several biological processes and diseases, e.g. in some psychiatric disorders, most probably through interference in the inositol cycle, it is important in the metabolism of substance P, arginine vasopressin, thyroliberin, and gonadoliberin, enzyme regulation, overview | Sus scrofa | ? | - |
? | |
| 3.4.21.26 | additional information | the enzyme removes most of the gut-digestion-resistant gliadin peptides in the host gut luman of coeliac disease patients, overview, enzyme regulation, overview | Flavobacterium sp. | ? | - |
? | |
| 3.4.21.26 | additional information | substrate specificity, overview, the enzyme cleaves at the C-terminal side of proline residues and more slowly of alanine residues, no activity with large proteins with over 30 amino acids | Mus musculus | ? | - |
? | |
| 3.4.21.26 | additional information | substrate specificity, overview, the enzyme cleaves at the C-terminal side of proline residues and more slowly of alanine residues, no activity with large proteins with over 30 amino acids | Homo sapiens | ? | - |
? | |
| 3.4.21.26 | additional information | substrate specificity, overview, the enzyme cleaves at the C-terminal side of proline residues and more slowly of alanine residues, no activity with large proteins with over 30 amino acids | Rattus norvegicus | ? | - |
? | |
| 3.4.21.26 | additional information | substrate specificity, overview, the enzyme cleaves at the C-terminal side of proline residues and more slowly of alanine residues, no activity with large proteins with over 30 amino acids | Sus scrofa | ? | - |
? | |
| 3.4.21.26 | additional information | the enzyme cleaves at the C-terminal side of proline residues, the bacterial enzyme is also capable of cleaving Ala-Xaa and Val-Xaa bonds, no activity with large proteins with over 30 amino acids | Flavobacterium sp. | ? | - |
? | |
| 3.4.21.26 | additional information | the enzyme cleaves at the C-terminal side of proline residues, the bacterial enzyme is also capable of cleaving Ala-Xaa and Val-Xaa bonds, no activity with large proteins with over 30 amino acids | Novosphingobium capsulatum | ? | - |
? | |
| 3.4.21.26 | neurotensin + H2O | - |
Mus musculus | ? | - |
? | |
| 3.4.21.26 | neurotensin + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.26 | neurotensin + H2O | - |
Rattus norvegicus | ? | - |
? | |
| 3.4.21.26 | neurotensin + H2O | - |
Sus scrofa | ? | - |
? | |
| 3.4.21.26 | oxytoxin + H2O | - |
Mus musculus | ? | - |
? | |
| 3.4.21.26 | oxytoxin + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.26 | oxytoxin + H2O | - |
Rattus norvegicus | ? | - |
? | |
| 3.4.21.26 | oxytoxin + H2O | - |
Sus scrofa | ? | - |
? | |
| 3.4.21.26 | Substance P + H2O | - |
Mus musculus | ? | - |
? | |
| 3.4.21.26 | Substance P + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.26 | Substance P + H2O | - |
Rattus norvegicus | ? | - |
? | |
| 3.4.21.26 | Substance P + H2O | - |
Sus scrofa | ? | - |
? | |
| 3.4.21.26 | thyrotropin releasing hormone + H2O | - |
Mus musculus | ? | - |
? | |
| 3.4.21.26 | thyrotropin releasing hormone + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.26 | thyrotropin releasing hormone + H2O | - |
Rattus norvegicus | ? | - |
? | |
| 3.4.21.26 | thyrotropin releasing hormone + H2O | - |
Sus scrofa | ? | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 3.4.21.26 | ? | x * 80000, about | Mus musculus |
| 3.4.21.26 | ? | x * 87000, extracellular isozyme, SDS-PAGE | Homo sapiens |
| 3.4.21.26 | More | the enzyme structure contains two domains, the peptidase domain consitst of N- and C-terminal residues 1-72 and 428-710 containing the catalytic triad Ser554, Asp641, and His680 and is arranged in a classical alpha/beta hydrolase fold, the seven-bladed beta-propeller domain, residues 73-427, is radially arranged around the central tunnel embedded within the cylinder, where the narrow active site is located | Sus scrofa |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.21.26 | POP | - |
Mus musculus |
| 3.4.21.26 | POP | - |
Homo sapiens |
| 3.4.21.26 | POP | - |
Rattus norvegicus |
| 3.4.21.26 | POP | - |
Dictyostelium discoideum |
| 3.4.21.26 | POP | - |
Flavobacterium sp. |
| 3.4.21.26 | POP | - |
Novosphingobium capsulatum |
| 3.4.21.26 | POP | - |
Sus scrofa |
| 3.4.21.26 | post-proline cleaving enzyme | - |
Homo sapiens |
| 3.4.21.26 | post-proline endopeptidase | - |
Homo sapiens |
| 3.4.21.26 | PPCE | - |
Homo sapiens |
| 3.4.21.26 | prolyl endopeptidase | - |
Homo sapiens |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.4.21.26 | 0.00000035 | - |
benzyloxycarbonyl-Pro-prolinal | - |
Mus musculus | |
| 3.4.21.26 | 0.00000083 | - |
JTP-4819 | - |
Rattus norvegicus | |
| 3.4.21.26 | 0.0000015 | - |
S-17092 | - |
Homo sapiens | |
| 3.4.21.26 | 0.0000072 | - |
SUAM-1221 | - |
Rattus norvegicus | |
| 3.4.21.26 | 0.000012 | - |
ONO-1603 | - |
Rattus norvegicus | |
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Release 2023.1 (January 2023)
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