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Literature summary extracted from

  • Shang, L.; Maeda, T.; Xu, W.; Kishioka, S.
    Evaluation of a novel aminopeptidase N inhibitor, in vitro, using two assay systems (2008), J. Enzyme Inhib. Med. Chem., 23, 198-205.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.11.2 amastatin competitive with hydrolysis of L-Tyr-L-Gly. Enhances Met-enkephalin-induced twitch inhibition of ileum preparations Cavia porcellus
3.4.11.2 beta-amino-alpha-hydroxyl-phenyl butanic acid-valine i.e. AHPA-Val, competitive with hydrolysis of L-Tyr-L-Gly. Enhances Met-enkephalin-induced twitch inhibition of ileum preparations Cavia porcellus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.11.2 membrane
-
 Cavia porcellus 16020
-

Organism

EC Number Organism UniProt Comment Textmining
3.4.11.2 Cavia porcellus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.11.2 striated muscle cell
-
 Cavia porcellus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.11.2 L-Tyr-Gly + H2O
-
 Cavia porcellus L-Tyr + Gly
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.4.11.2 0.0125
-
 amastatin
-
 Cavia porcellus
3.4.11.2 0.014
-
 beta-amino-alpha-hydroxyl-phenyl butanic acid-valine
-
 Cavia porcellus