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Literature summary extracted from

  • Bodineau, L.; Frugiere, A.; Marc, Y.; Claperon, C.; Llorens-Cortes, C.
    Aminopeptidase A inhibitors as centrally acting antihypertensive agents (2008), Heart Fail. Rev., 13, 311-319.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.4.11.7 medicine central APA is a potential therapeutic target for the treatment of hypertension Mus musculus
3.4.11.7 medicine central APA is a potential therapeutic target for the treatment of hypertension Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.11.7 (S)-3-amino-4-mercaptobutyl sulfonic acid EC33, specific and selective APA inhibitor Mus musculus
3.4.11.7 (S)-3-amino-4-mercaptobutyl sulfonic acid EC33, specific and selective APA inhibitor Rattus norvegicus
3.4.11.7 4,4'-dithio[bis(3)-aminobutylsulfonic acid] RB150, a prodrug of EC33 Rattus norvegicus
3.4.11.7 4,4'-dithio[bis(3-aminobutyl sulfonic acid)] RB150, a prodrug of EC33 Mus musculus
3.4.11.7 amastatin inhibits APA and APN Mus musculus
3.4.11.7 amastatin inhibits APA and APN Rattus norvegicus
3.4.11.7 bestatin broad specificity for various aminopeptidases Mus musculus
3.4.11.7 bestatin broad specificity for various aminopeptidases Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.11.7 Zn2+
-
 Mus musculus
3.4.11.7 Zn2+
-
 Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.11.7 120000
-
 monomer Mus musculus
3.4.11.7 120000
-
 monomer Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
3.4.11.7 Mus musculus
-
-
-
3.4.11.7 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.11.7 brain
-
 Mus musculus
-
3.4.11.7 brain
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.11.7 angiotensin II + H2O angiotensin II: Asp-Arg-Val-Tyr-Ile-His-Pro-Phe Mus musculus aspartic acid + angiotensin III angiotensin III: Arg-Val-Tyr-Ile-His-Pro-Phe ?
3.4.11.7 angiotensin II + H2O angiotensin II: Asp-Arg-Val-Tyr-Ile-His-Pro-Phe Rattus norvegicus aspartic acid + angiotensin III angiotensin III: Arg-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe ?

Synonyms

EC Number Synonyms Comment Organism
3.4.11.7 aminopeptidase A
-
 Mus musculus
3.4.11.7 aminopeptidase A
-
 Rattus norvegicus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.4.11.7 0.00025
-
 (S)-3-amino-4-mercaptobutyl sulfonic acid
-
 Rattus norvegicus
3.4.11.7 0.00025
-
 [(S)-3-amino-4-mercaptobutyl sulfonic acid]
-
 Mus musculus