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Literature summary extracted from

  • Demaegdt, H.; Lenaerts, P.J.; Swales, J.; De Backer, J.P.; Laeremans, H.; Le, M.T.; Kersemans, K.; Vogel, L.K.; Michotte, Y.; Vanderheyden, P.; Vauquelin, G.
    Angiotensin AT4 receptor ligand interaction with cystinyl aminopeptidase and aminopeptidase N: [125I]angiotensin IV only binds to the cystinyl aminopeptidase apo-enzyme (2006), Eur. J. Pharmacol., 546, 19-27.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.11.2 expression in HEK-293 cell Homo sapiens
3.4.11.3 expression in HEK-293 cell Cricetulus griseus
3.4.11.3 expression in HEK-293 cell Homo sapiens
3.4.11.3 expression in HEK-293 cell Bos taurus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.11.2 angiotensin 4-8
-
Homo sapiens
3.4.11.2 angiotensin II
-
Homo sapiens
3.4.11.2 angiotensin III
-
Homo sapiens
3.4.11.2 angiotensin IV
-
Homo sapiens
3.4.11.2 divalinal
-
Homo sapiens
3.4.11.2 LVV-hemorphin 7
-
Homo sapiens
3.4.11.2 additional information inhibitory potency in decreasing order: angiotensin IV, angiotensin III, divalinal/angiotensin IV, LVV-hemorphin 7, angiotensin 4-8, angiotensin III Homo sapiens
3.4.11.3 angiotensin 4-8
-
Bos taurus
3.4.11.3 angiotensin 4-8
-
Cricetulus griseus
3.4.11.3 angiotensin 4-8
-
Homo sapiens
3.4.11.3 angiotensin 4-8
-
Mus musculus
3.4.11.3 angiotensin II
-
Bos taurus
3.4.11.3 angiotensin II
-
Cricetulus griseus
3.4.11.3 angiotensin II
-
Homo sapiens
3.4.11.3 angiotensin II
-
Mus musculus
3.4.11.3 angiotensin III
-
Bos taurus
3.4.11.3 angiotensin III
-
Cricetulus griseus
3.4.11.3 angiotensin III
-
Homo sapiens
3.4.11.3 angiotensin III
-
Mus musculus
3.4.11.3 angiotensin IV
-
Bos taurus
3.4.11.3 angiotensin IV
-
Cricetulus griseus
3.4.11.3 angiotensin IV
-
Homo sapiens
3.4.11.3 angiotensin IV
-
Mus musculus
3.4.11.3 divalinal
-
Bos taurus
3.4.11.3 divalinal
-
Cricetulus griseus
3.4.11.3 divalinal
-
Homo sapiens
3.4.11.3 divalinal
-
Mus musculus
3.4.11.3 LVV-hemorphin 7
-
Bos taurus
3.4.11.3 LVV-hemorphin 7
-
Cricetulus griseus
3.4.11.3 LVV-hemorphin 7
-
Homo sapiens
3.4.11.3 LVV-hemorphin 7
-
Mus musculus
3.4.11.3 additional information inhibitory potency in decreasing order: angiotensin III, angiotensin IV, LVV-hemorphin 7, divalinal/angiotensin IV, angiotensin II, angiotensin 4-8 Bos taurus
3.4.11.3 additional information inhibitory potency in decreasing order: angiotensin IV, angiotensin III, LVV-hemorphin 7, divalinal/angiotensin IV, angiotensin 4-8, angiotensin III Cricetulus griseus
3.4.11.3 additional information inhibitory potency in decreasing order: angiotensin IV, angiotensin III, divalinal/angiotensin IV, LVV-hemorphin 7, angiotensin 4-8, angiotensin III Homo sapiens
3.4.11.3 additional information inhibitory potency in decreasing order: angiotensin IV, angiotensin III, divalinal/angiotensin IV, LVV-hemorphin 7, angiotensin 4-8, angiotensin III Mus musculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.11.2 0.25
-
L-Leu-4-nitroanilide pH 7.4, 37°C Homo sapiens
3.4.11.3 0.25
-
L-Leu-4-nitroanilide pH 7.4, 37°C Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.11.2 membrane comparison of enzyme activity in membranes of COS-7 cells, HEK-293 cells, SK-N-MC cells, CHO-K1 cells and MDBK cells. In all cell types, cystinyl aminopeptidase predominates over aminopepetidase N Homo sapiens 16020
-
3.4.11.3 membrane comparison of enzyme activity in membranes of COS-7 cells, HEK-293 cells, SK-N-MC cells, CHO-K1 cells and MDBK cells. Comparatively, CHO-K1 cells display the highest level of enzyme. In all cell types, the enzyme predominates over aminopeptidase N Cricetulus griseus 16020
-
3.4.11.3 membrane comparison of enzyme activity in membranes of COS-7 cells, HEK-293 cells, SK-N-MC cells, CHO-K1 cells and MDBK cells. Comparatively, CHO-K1 cells display the highest level of enzyme. In all cell types, the enzyme predominates over aminopeptidase N Mus musculus 16020
-
3.4.11.3 membrane comparison of enzyme activity in membranes of COS-7 cells, HEK-293 cells, SK-N-MC cells, CHO-K1 cells and MDBK cells. Comparatively, CHO-K1 cells display the highest level of enzyme. In all cell types, the enzyme predominates over aminopeptidase N Homo sapiens 16020
-
3.4.11.3 membrane comparison of enzyme activity in membranes of COS-7 cells, HEK-293 cells, SK-N-MC cells, CHO-K1 cells and MDBK cells. Comparatively, CHO-K1 cells display the highest level of enzyme. In all cell types, the enzyme predominates over aminopeptidase N Bos taurus 16020
-

Organism

EC Number Organism UniProt Comment Textmining
3.4.11.2 Homo sapiens
-
-
-
3.4.11.3 Bos taurus
-
-
-
3.4.11.3 Cricetulus griseus
-
-
-
3.4.11.3 Homo sapiens
-
-
-
3.4.11.3 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.11.2 HEK-293 cell
-
Homo sapiens
-
3.4.11.2 SK-N-MC cell
-
Homo sapiens
-
3.4.11.3 CHO-K1 cell
-
Cricetulus griseus
-
3.4.11.3 HEK-293 cell
-
Homo sapiens
-
3.4.11.3 MDBK cell Madin-Darby bovine kidney cell Bos taurus
-
3.4.11.3 SK-N-MC cell
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.11.2 L-Leu-4-nitroanilide + H2O
-
Homo sapiens L-Leu + 4-nitroaniline
-
?
3.4.11.3 L-Leu-4-nitroanilide + H2O
-
Cricetulus griseus L-Leu + 4-nitroaniline
-
?
3.4.11.3 L-Leu-4-nitroanilide + H2O
-
Mus musculus L-Leu + 4-nitroaniline
-
?
3.4.11.3 L-Leu-4-nitroanilide + H2O
-
Homo sapiens L-Leu + 4-nitroaniline
-
?
3.4.11.3 L-Leu-4-nitroanilide + H2O
-
Bos taurus L-Leu + 4-nitroaniline
-
?