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Literature summary extracted from

  • Bonferoni, M.C.; Sandri, G.; Rossi, S.; Ferrari, F.; Gibin, S.; Caramella, C.
    Chitosan citrate as multifunctional polymer for vaginal delivery. Evaluation of penetration enhancement and peptidase inhibition properties (2008), Eur. J. Pharm. Sci., 33, 166-176.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.17.1 chitosan citrate
-
 Bos taurus
3.4.17.1 chitosan citrate
-
 Sus scrofa
3.4.17.1 chitosan hydrochloride
-
 Bos taurus
3.4.17.1 chitosan hydrochloride
-
 Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
3.4.17.1 Bos taurus
-
-
-
3.4.17.1 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.17.1 mucosa vaginal mucosa Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.17.1 hippuryl-L-phenylalanine + H2O assay substrate Bos taurus hippuric acid + L-phenylalanine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.17.1 carboxypeptidase a
-
 Sus scrofa
3.4.17.1 carboxypeptidase a
-
 Bos taurus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.17.1 22
-
 activity assay at room temperature Bos taurus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.17.1 6.5
-
 activity assay, suboptimal condition because chitosan is soluble only until pH 6-6.5 Bos taurus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
3.4.17.1 7 8
-
 Bos taurus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.4.17.1 additional information
-
 additional information residual enzyme activity, 0.2% chitosan hydrochloride 55% activity, 0.2% chitosan citrate 0% activity, 0.04% 8% activity, 0.02% 15% activity, 0.01% 65% activity Bos taurus