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Literature summary extracted from

  • Kovacs, K.; Zhang, L.; Linforth, R.S.; Whittaker, B.; Hayes, C.J.; Fray, R.G.
    Redirection of carotenoid metabolism for the efficient production of taxadiene [taxa-4(5),11(12)-diene] in transgenic tomato fruit (2007), Transgenic Res., 16, 121-126.
    View publication on PubMed

Application

EC Number Application Comment Organism
4.2.3.17 medicine taxanes can be used in cancer treatment Taxus baccata

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.2.3.17 cDNA is directly cloned into the pGemT-Easy vector, sequenced and cloned into the plant binary transformation vector pBC35. Furthermore it is subcloned into pBluescript, released and ligated into pRD12. The pBC35 and pRD12 constructs are transferred to Agrobacterium tumefaciens and used to transform tomato cotyledons Taxus baccata

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.2.3.17 geranylgeranyl diphosphate Taxus baccata
-
taxa-4,11-diene + diphosphate
-
?

Organism

EC Number Organism UniProt Comment Textmining
4.2.3.17 Taxus baccata Q93YA3
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.3.17 geranylgeranyl diphosphate
-
Taxus baccata taxa-4,11-diene + diphosphate
-
?

Synonyms

EC Number Synonyms Comment Organism
4.2.3.17 taxadiene synthase
-
Taxus baccata