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Literature summary extracted from

  • Moore, N.L.; Narayanan, R.; Weigel, N.L.
    Cyclin dependent kinase 2 and the regulation of human progesterone receptor activity (2007), Steroids, 72, 202-209.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.22 cyclin A
-
Homo sapiens
2.7.11.22 cyclin E
-
Homo sapiens
2.7.11.22 additional information Cdk activating kinase Homo sapiens
2.7.11.22 progestin
-
Homo sapiens

Application

EC Number Application Comment Organism
2.7.11.22 medicine cyclin A/Cdk2 has profound effects on progesterone receptor activity and may have clinical implications for patients receiving antiprogestin therapies, multifaceted role for Cdk2 in the regulation of progesterone receptor transcriptional activity Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.22 overexpression in HeLa cells Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.7.11.22 additional information dominant active Cdk2 mutant, increased progesterone receptor activity in cells overexpressing the mutant Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.22 Cdk2 inhibitor II
-
Homo sapiens
2.7.11.22 p21
-
Homo sapiens
2.7.11.22 p27
-
Homo sapiens
2.7.11.22 progesterone
-
Homo sapiens
2.7.11.22 roscovitine binds to the ATP binding pocket of Cdk2, preventing phosphate transfer from ATP to the protein substrate Homo sapiens
2.7.11.22 siRNA knock down of Cdk2 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.22 ATP + histone H1 Homo sapiens
-
ADP + phosphorylated steroid histone H1
-
?
2.7.11.22 ATP + progesterone receptor Homo sapiens cyclin A2/Cdk2 phosphorylates progesterone receptor in vivo at Ser20 and Ser676, Ser162, Ser190 and Ser400 ADP + phosphorylated progesterone receptor
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.22 Homo sapiens
-
-
-
2.7.11.22 Rattus norvegicus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.22 ATP + CREB-binding protein
-
Homo sapiens ADP + phosphorylated CREB-binding protein
-
?
2.7.11.22 ATP + estrogen receptor Cdk2 phosphorylation at Ser104 and Ser106 Homo sapiens ADP + phosphorylated estrogen receptor
-
?
2.7.11.22 ATP + glucocorticoid receptor
-
Homo sapiens ADP + phosphorylated glucocorticoid receptor
-
?
2.7.11.22 ATP + glucocorticoid receptor
-
Rattus norvegicus ADP + phosphorylated glucocorticoid receptor
-
?
2.7.11.22 ATP + histone H1
-
Homo sapiens ADP + phosphorylated steroid histone H1
-
?
2.7.11.22 ATP + progesterone receptor cyclin A2/Cdk2 phosphorylates progesterone receptor in vivo at Ser20 and Ser676, Ser162, Ser190 and Ser400 Homo sapiens ADP + phosphorylated progesterone receptor
-
?
2.7.11.22 ATP + progesterone receptor cyclin A2/Cdk2 phosphorylates progesterone receptor in vitro at Ser25, Ser162, Ser190, Ser213, Ser400, Thr 430, Ser554 and Ser676 Homo sapiens ADP + phosphorylated progesterone receptor
-
?
2.7.11.22 ATP + steroid receptor coactivator-1
-
Homo sapiens ADP + phosphorylated steroid receptor coactivator-1
-
?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.22 cyclin A2/Cdk2
-
Homo sapiens
2.7.11.22 cyclin A2/Cdk2
-
Rattus norvegicus
2.7.11.22 cyclin dependent kinase 2
-
Homo sapiens
2.7.11.22 cyclin dependent kinase 2
-
Rattus norvegicus