EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
2.7.11.22 | cyclin A | - |
Homo sapiens | |
2.7.11.22 | cyclin E | - |
Homo sapiens | |
2.7.11.22 | additional information | Cdk activating kinase | Homo sapiens | |
2.7.11.22 | progestin | - |
Homo sapiens |
EC Number | Application | Comment | Organism |
---|---|---|---|
2.7.11.22 | medicine | cyclin A/Cdk2 has profound effects on progesterone receptor activity and may have clinical implications for patients receiving antiprogestin therapies, multifaceted role for Cdk2 in the regulation of progesterone receptor transcriptional activity | Homo sapiens |
EC Number | Cloned (Comment) | Organism |
---|---|---|
2.7.11.22 | overexpression in HeLa cells | Homo sapiens |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
2.7.11.22 | additional information | dominant active Cdk2 mutant, increased progesterone receptor activity in cells overexpressing the mutant | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.7.11.22 | Cdk2 inhibitor II | - |
Homo sapiens | |
2.7.11.22 | p21 | - |
Homo sapiens | |
2.7.11.22 | p27 | - |
Homo sapiens | |
2.7.11.22 | progesterone | - |
Homo sapiens | |
2.7.11.22 | roscovitine | binds to the ATP binding pocket of Cdk2, preventing phosphate transfer from ATP to the protein substrate | Homo sapiens | |
2.7.11.22 | siRNA | knock down of Cdk2 | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.11.22 | ATP + histone H1 | Homo sapiens | - |
ADP + phosphorylated steroid histone H1 | - |
? | |
2.7.11.22 | ATP + progesterone receptor | Homo sapiens | cyclin A2/Cdk2 phosphorylates progesterone receptor in vivo at Ser20 and Ser676, Ser162, Ser190 and Ser400 | ADP + phosphorylated progesterone receptor | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.11.22 | Homo sapiens | - |
- |
- |
2.7.11.22 | Rattus norvegicus | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.11.22 | ATP + CREB-binding protein | - |
Homo sapiens | ADP + phosphorylated CREB-binding protein | - |
? | |
2.7.11.22 | ATP + estrogen receptor | Cdk2 phosphorylation at Ser104 and Ser106 | Homo sapiens | ADP + phosphorylated estrogen receptor | - |
? | |
2.7.11.22 | ATP + glucocorticoid receptor | - |
Homo sapiens | ADP + phosphorylated glucocorticoid receptor | - |
? | |
2.7.11.22 | ATP + glucocorticoid receptor | - |
Rattus norvegicus | ADP + phosphorylated glucocorticoid receptor | - |
? | |
2.7.11.22 | ATP + histone H1 | - |
Homo sapiens | ADP + phosphorylated steroid histone H1 | - |
? | |
2.7.11.22 | ATP + progesterone receptor | cyclin A2/Cdk2 phosphorylates progesterone receptor in vivo at Ser20 and Ser676, Ser162, Ser190 and Ser400 | Homo sapiens | ADP + phosphorylated progesterone receptor | - |
? | |
2.7.11.22 | ATP + progesterone receptor | cyclin A2/Cdk2 phosphorylates progesterone receptor in vitro at Ser25, Ser162, Ser190, Ser213, Ser400, Thr 430, Ser554 and Ser676 | Homo sapiens | ADP + phosphorylated progesterone receptor | - |
? | |
2.7.11.22 | ATP + steroid receptor coactivator-1 | - |
Homo sapiens | ADP + phosphorylated steroid receptor coactivator-1 | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.7.11.22 | cyclin A2/Cdk2 | - |
Homo sapiens |
2.7.11.22 | cyclin A2/Cdk2 | - |
Rattus norvegicus |
2.7.11.22 | cyclin dependent kinase 2 | - |
Homo sapiens |
2.7.11.22 | cyclin dependent kinase 2 | - |
Rattus norvegicus |