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Literature summary extracted from

  • Byun, H.S.; Song, J.K.; Kim, Y.R.; Piao, L.; Won, M.; Park, K.A.; Choi, B.L.; Lee, H.; Hong, J.H.; Park, J.; Seok, J.H.; Lee, Y.J.; Kang, S.W.; Hur, G.M.
    Caspase-8 has an essential role in resveratrol-induced apoptosis of rheumatoid fibroblast-like synoviocytes (2008), Rheumatology, 47, 301-308.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.22.61 resveratrol causes activation of caspase-8, which in turn results in modulation of mitochondrial apoptotic machinery to promote apoptosis of rheumatoid arthritis fibroblast-like synoviocytes Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.61 Homo sapiens
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.22.61 rheumatoid arthritis fibroblast-like synoviocyte activation of caspase-8 is essential for triggering resveratrol-induced apoptotic signalling via the involvement of the mitochondrial pathway in rheumatoid arthritis fibroblast-like synoviocytes. Resveratrol causes activation of caspase-8, which in turn results in modulation of mitochondrial apoptotic machinery to promote apoptosis of rheumatoid arthritis fibroblast-like synoviocytes Homo sapiens
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