Any feedback?
Literature summary extracted from
- Structure, mechanism, regulation and evolution of class III nucleotidyl cyclases (2007), Rev. Physiol. Biochem. Pharmacol., 157, 105-140.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.6.1.1 | bicarbonate | - |
Arthrospira platensis |  |
| 4.6.1.1 | forskolin | - |
Rattus norvegicus | |
| 4.6.1.1 | Galphas | stimulates the VC1-IIC2 heterodimer | Rattus norvegicus | |
| 4.6.1.1 | Galphas | stimulates the VC1-IIC2 heterodimer | Canis lupus familiaris | |
| 4.6.1.1 | additional information | is activated by different host cell factors and is inactive until injected into the host cell | Pseudomonas aeruginosa | |
| 4.6.1.1 | additional information | is activated by different host cell factors and is inactive until injected into the host cell | Bordetella pertussis | |
| 4.6.1.1 | additional information | is activated by different host cell factors and is inactive until injected into the host cell | Bacillus anthracis | |
| 4.6.1.1 | additional information | Rv1264 is a pH-regulated enzyme | Mycobacterium tuberculosis |
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 4.6.1.1 | additional information | contains a GGDEF domain | Caulobacter vibrioides |
| 4.6.1.1 | additional information | is an exotoxin | Pseudomonas aeruginosa |
| 4.6.1.1 | additional information | is an exotoxin | Bordetella pertussis |
| 4.6.1.1 | additional information | is an exotoxin | Bacillus anthracis |
| 4.6.1.1 | additional information | restores adenylate cyclase activity in Escherichia coli knockout mutants | Sinorhizobium meliloti |
| 4.6.1.1 | additional information | restores adenylate cyclase activity in Escherichia coli knockout mutants | Rhizobium etli |
| 4.6.1.1 | additional information | restores adenylate cyclase activity in Escherichia coli knockout mutants | Aeromonas hydrophila |
| 4.6.1.1 | additional information | restores adenylate cyclase activity in Escherichia coli knockout mutants | Prevotella ruminicola |
| 4.6.1.1 | additional information | Rv1264 plays a role in mycobacterial survival in the acidic environment of the pahgolysosome | Mycobacterium tuberculosis |
Crystallization (Commentary)
| EC Number | Crystallization (Comment) | Organism |
|---|---|---|
| 4.6.1.1 | Rv1264 crystallized at neutral and acidic pH, CHD activity regulated by dramatic conformational changes | Mycobacterium tuberculosis |
| 4.6.1.1 | VC1-IIC2 heterodimer in complex with ATP analogs | Rattus norvegicus |
| 4.6.1.1 | VC1-IIC2 heterodimer in complex with ATP analogs | Canis lupus familiaris |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.6.1.1 | AMPCPP | - |
Arthrospira platensis | |
| 4.6.1.1 | catechol | noncompetetive inhibitor | Arthrospira platensis | |
| 4.6.1.1 | MANT-GTP | inhibits the VC1-IIC2 heterodimer | Canis lupus familiaris | |
| 4.6.1.1 | MANT-GTP | inhibits the VC1-IIC2 heterodimer | Rattus norvegicus | |
| 4.6.1.1 | additional information | PleD is subject to tight feedback inhibition by the product c-diGMP | Caulobacter vibrioides |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.6.1.1 | Ca2+ | - |
Arthrospira platensis | |
| 4.6.1.1 | Mg2+ | - |
Rattus norvegicus | |
| 4.6.1.1 | Mg2+ | - |
Canis lupus familiaris | |
| 4.6.1.1 | Mg2+ | - |
Arthrospira platensis | |
| 4.6.1.1 | Mn2+ | - |
Rattus norvegicus | |
| 4.6.1.1 | Mn2+ | - |
Canis lupus familiaris | |
| 4.6.1.1 | Mn2+ | Rv1900c | Mycobacterium tuberculosis | |
| 4.6.1.1 | additional information | no metals bound in the structure of the c-diGMP-bound PleD complex | Caulobacter vibrioides |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.6.1.1 | Aeromonas hydrophila | - |
- |
- |
| 4.6.1.1 | Arthrospira platensis | - |
- |
- |
| 4.6.1.1 | Bacillus anthracis | - |
- |
- |
| 4.6.1.1 | Bordetella pertussis | - |
- |
- |
| 4.6.1.1 | Canis lupus familiaris | - |
- |
- |
| 4.6.1.1 | Caulobacter vibrioides | - |
- |
- |
| 4.6.1.1 | Escherichia sp. | - |
- |
- |
| 4.6.1.1 | Haemophilus sp. | - |
- |
- |
| 4.6.1.1 | Mycobacterium tuberculosis | - |
- |
- |
| 4.6.1.1 | Prevotella ruminicola | - |
- |
- |
| 4.6.1.1 | Pseudomonas aeruginosa | - |
- |
- |
| 4.6.1.1 | Pseudomonas sp. | - |
- |
- |
| 4.6.1.1 | Rattus norvegicus | - |
- |
- |
| 4.6.1.1 | Rhizobium etli | - |
- |
- |
| 4.6.1.1 | Sinorhizobium meliloti | - |
- |
- |
| 4.6.1.1 | Trypanosoma brucei | - |
- |
- |
| 4.6.1.1 | Vibrio parahaemolyticus | - |
- |
- |
| 4.6.1.1 | Yersinia pestis | - |
- |
- |
| 4.6.1.1 | Yersinia sp. | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.6.1.1 | 2 GTP | - |
Caulobacter vibrioides | c-diGMP + 2 diphosphate | - |
? | |
| 4.6.1.1 | ATP | - |
Sinorhizobium meliloti | 3',5'-cAMP + diphosphate | - |
? | |
| 4.6.1.1 | ATP | - |
Rattus norvegicus | 3',5'-cAMP + diphosphate | - |
? | |
| 4.6.1.1 | ATP | - |
Canis lupus familiaris | 3',5'-cAMP + diphosphate | - |
? | |
| 4.6.1.1 | ATP | - |
Arthrospira platensis | 3',5'-cAMP + diphosphate | - |
? | |
| 4.6.1.1 | ATP | Rv1900, C-terminal CHD can use both ATP and GTP as substrate but has a 14fold preference for ATP | Mycobacterium tuberculosis | 3',5'-cAMP + diphosphate | - |
? | |
| 4.6.1.1 | GTP | Rv1900 | Mycobacterium tuberculosis | ? | - |
? | |
| 4.6.1.1 | GTP | - |
Sinorhizobium meliloti | 3',5'-cGMP + diphosphate | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 4.6.1.1 | dimer | - |
Caulobacter vibrioides |
| 4.6.1.1 | heterodimer | - |
Rattus norvegicus |
| 4.6.1.1 | homodimer | - |
Arthrospira platensis |
| 4.6.1.1 | homodimer | Rv1900c and Rv1264 | Mycobacterium tuberculosis |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 4.6.1.1 | class I AC | - |
Pseudomonas sp. |
| 4.6.1.1 | class I AC | - |
Yersinia sp. |
| 4.6.1.1 | class I AC | - |
Escherichia sp. |
| 4.6.1.1 | class I AC | - |
Haemophilus sp. |
| 4.6.1.1 | class II AC | - |
Pseudomonas aeruginosa |
| 4.6.1.1 | class II AC | - |
Bordetella pertussis |
| 4.6.1.1 | class II AC | - |
Bacillus anthracis |
| 4.6.1.1 | class III AC | - |
Rattus norvegicus |
| 4.6.1.1 | class III AC | - |
Trypanosoma brucei |
| 4.6.1.1 | class III AC | - |
Canis lupus familiaris |
| 4.6.1.1 | class III AC | - |
Mycobacterium tuberculosis |
| 4.6.1.1 | class III AC | - |
Caulobacter vibrioides |
| 4.6.1.1 | class III AC | - |
Arthrospira platensis |
| 4.6.1.1 | class IV AC | - |
Aeromonas hydrophila |
| 4.6.1.1 | class IV AC | - |
Yersinia pestis |
| 4.6.1.1 | class IV AC | - |
Vibrio parahaemolyticus |
| 4.6.1.1 | class V AC | - |
Prevotella ruminicola |
| 4.6.1.1 | class VI AC | - |
Rhizobium etli |
| 4.6.1.1 | Cya1 | - |
Sinorhizobium meliloti |
| 4.6.1.1 | CyaA | - |
Bordetella pertussis |
| 4.6.1.1 | cyaC | - |
Arthrospira platensis |
| 4.6.1.1 | Edema factor | - |
Bacillus anthracis |
| 4.6.1.1 | GRESAG 4.1 | - |
Trypanosoma brucei |
| 4.6.1.1 | GRESAG 4.3 | - |
Trypanosoma brucei |
| 4.6.1.1 | IIC2 | - |
Rattus norvegicus |
| 4.6.1.1 | PleD | - |
Caulobacter vibrioides |
| 4.6.1.1 | Rv1264 | - |
Mycobacterium tuberculosis |
| 4.6.1.1 | Rv1625c | - |
Mycobacterium tuberculosis |
| 4.6.1.1 | Rv1900c | - |
Mycobacterium tuberculosis |
| 4.6.1.1 | type II AC | - |
Rattus norvegicus |
| 4.6.1.1 | type V AC | - |
Canis lupus familiaris |
| 4.6.1.1 | VC1 | - |
Canis lupus familiaris |
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