EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
3.4.21.53 | ethanol | - |
Bacillus subtilis | |
3.4.21.53 | H2O2 | - |
Bacillus subtilis | |
3.4.21.53 | additional information | lon gene is heat shock-induced | Escherichia coli | |
3.4.21.53 | additional information | lon gene is heat shock-induced | Streptomyces lividans | |
3.4.21.53 | additional information | lon gene is not heat shock-induced | Brevibacillus brevis | |
3.4.21.53 | additional information | lon gene is not heat shock-induced | Myxococcus xanthus | |
3.4.21.53 | additional information | lonA gene is induced by heat and salt, lonB is not stress-induced | Bacillus subtilis | |
3.4.21.53 | Polyphosphate | stimulates lon proteolytic activity, affects substrate preference and oligomeric state of the enzyme | Escherichia coli | |
3.4.21.53 | puromycin | - |
Bacillus subtilis |
EC Number | Application | Comment | Organism |
---|---|---|---|
3.4.21.53 | medicine | lon downregulates virulence, is involved in transcriptional regulation of type three secretion systems to translocate virulence proteins | Pseudomonas syringae |
3.4.21.53 | medicine | lon downregulates virulence, is involved in transcriptional regulation of type three secretion systems to translocate virulence proteins. Oppositely modulates infection stages (epithelial invasion and survival within murine macrophages) | Salmonella enterica subsp. enterica serovar Typhimurium |
3.4.21.53 | medicine | lon upregulates virulence, is involved in transcriptional regulation of type three secretion systems to translocate virulence proteins | Yersinia pestis |
3.4.21.53 | additional information | lon is involved in the control of swarmer cell differentiation | Proteus mirabilis |
3.4.21.53 | additional information | lon is required for cell cycle-dependent regulation of methylation, correct completion of cell division and normal progression of the cell cycle | Caulobacter vibrioides |
3.4.21.53 | additional information | lon plays a role in protein quality control by destroying unfolded proteins, it participates in regulatory circuits by controlling amount and availability of specific substrates | Escherichia coli |
3.4.21.53 | additional information | lonA plays a major role in initiating sporulation in response to environmental conditions, lonB is forespore-specific and may have a limited role in the regulation of sporulation | Bacillus subtilis |
3.4.21.53 | additional information | lonV gene is essential for viability, lonD gene is essential for spore and fruiting body formation | Myxococcus xanthus |
EC Number | Crystallization (Comment) | Organism |
---|---|---|
3.4.21.53 | carboxy-terminal domain crystallized | Escherichia coli |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
3.4.21.53 | additional information | attempts to construct a lonV mutant fail, lonD mutants are unable to sporulate | Myxococcus xanthus |
3.4.21.53 | additional information | lon mutants, accumulate abnormal proteins | Salmonella enterica subsp. enterica serovar Typhimurium |
3.4.21.53 | additional information | lon mutants, accumulate abnormal proteins, form mucoid colonies and long filaments, fail to adapt rapidly to a nutrional downshift, are sensitive to UV at 30°C because of SulA accumulation, at higher temperatures they lose their sensitivity because ClpYQ takes over SulA degredation | Escherichia coli |
3.4.21.53 | additional information | lon mutants, are unable to survive and proliferate murine macrophages, are extremely susceptible to hydrogen peroxide | Salmonella enterica subsp. enterica serovar Typhimurium |
3.4.21.53 | additional information | lon mutants, constitutively express the hrp regulon, hypersecrete effector proteins | Pseudomonas syringae |
3.4.21.53 | additional information | lon mutants, show defects in cell division, are unable to control initiation of DNA replication | Caulobacter vibrioides |
3.4.21.53 | additional information | lonB disruption does not affect sporulation | Bacillus subtilis |
3.4.21.53 | additional information | lonS mutants, constitutively differentiated in the swarmer mode | Vibrio parahaemolyticus |
3.4.21.53 | additional information | Pim1 mutants, are respiratory-deficient and unable to grow on non-fermentable carbon sources | Saccharomyces cerevisiae |
3.4.21.53 | additional information | total loss of lon activity leads to apoptosis | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.21.53 | additional information | inhibition of activity by the T4-encoded PinA protein, non-competetive inhibitor | Escherichia coli |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
3.4.21.53 | mitochondrion | - |
Homo sapiens | 5739 | - |
3.4.21.53 | mitochondrion | - |
Saccharomyces cerevisiae | 5739 | - |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.21.53 | Bacillus subtilis | - |
- |
- |
3.4.21.53 | Brevibacillus brevis | - |
- |
- |
3.4.21.53 | Caulobacter vibrioides | - |
- |
- |
3.4.21.53 | Escherichia coli | - |
- |
- |
3.4.21.53 | Homo sapiens | - |
- |
- |
3.4.21.53 | Myxococcus xanthus | - |
- |
- |
3.4.21.53 | no activity in Lactobacillus sp. | - |
- |
- |
3.4.21.53 | no activity in Mycobacterium leprae | - |
- |
- |
3.4.21.53 | no activity in Mycobacterium tuberculosis | - |
- |
- |
3.4.21.53 | no activity in Streptococcus sp. | - |
- |
- |
3.4.21.53 | Proteus mirabilis | - |
- |
- |
3.4.21.53 | Pseudomonas syringae | - |
- |
- |
3.4.21.53 | Saccharomyces cerevisiae | - |
- |
- |
3.4.21.53 | Salmonella enterica subsp. enterica serovar Typhimurium | - |
- |
- |
3.4.21.53 | Streptomyces lividans | - |
- |
- |
3.4.21.53 | Vibrio parahaemolyticus | - |
- |
- |
3.4.21.53 | Yersinia pestis | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.4.21.53 | spore | - |
Myxococcus xanthus | - |
3.4.21.53 | spore | lonA is involved in the control of sporulation initiation, lonB is only present in the forespore | Bacillus subtilis | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.21.53 | CcdA + H2O | - |
Escherichia coli | ? | - |
? | |
3.4.21.53 | CcrM + H2O | - |
Caulobacter vibrioides | ? | - |
? | |
3.4.21.53 | FlhC + H2O | - |
Proteus mirabilis | ? | - |
? | |
3.4.21.53 | FlhD + H2O | - |
Proteus mirabilis | ? | - |
? | |
3.4.21.53 | heat shock sigma factor 32 + H2O | degraded by synergistic action of lon, Clp and HflB | Escherichia coli | ? | - |
? | |
3.4.21.53 | HemA + H2O | conditional proteolysis mediated by lon and ClpAP | Salmonella enterica subsp. enterica serovar Typhimurium | ? | - |
? | |
3.4.21.53 | HilC + H2O | - |
Salmonella enterica subsp. enterica serovar Typhimurium | ? | - |
? | |
3.4.21.53 | HilD + H2O | - |
Salmonella enterica subsp. enterica serovar Typhimurium | ? | - |
? | |
3.4.21.53 | homoserine trans-succinylase + H2O | degraded by synergistic action of lon, ClpYQ, ClpXP and/or ClpAP | Escherichia coli | ? | - |
? | |
3.4.21.53 | HrpR + H2O | - |
Pseudomonas syringae | ? | - |
? | |
3.4.21.53 | MarA + H2O | - |
Escherichia coli | ? | - |
? | |
3.4.21.53 | MazE antitoxin + H2O | - |
Escherichia coli | ? | - |
? | |
3.4.21.53 | PasA + H2O | - |
Escherichia coli | ? | - |
? | |
3.4.21.53 | PemI + H2O | - |
Escherichia coli | ? | - |
? | |
3.4.21.53 | RelB antitoxin + H2O | - |
Escherichia coli | ? | - |
? | |
3.4.21.53 | ribosomal L13 protein + H2O | - |
Escherichia coli | ? | - |
? | |
3.4.21.53 | ribosomal L9 protein + H2O | - |
Escherichia coli | ? | - |
? | |
3.4.21.53 | ribosomal S2 protein + H2O | - |
Escherichia coli | ? | - |
? | |
3.4.21.53 | sigma factor G + H2O | lonA | Bacillus subtilis | ? | - |
? | |
3.4.21.53 | sigma factor H + H2O | lonA | Bacillus subtilis | ? | - |
? | |
3.4.21.53 | SMC protein + H2O | lonA | Bacillus subtilis | ? | - |
? | |
3.4.21.53 | SoxS + H2O | - |
Escherichia coli | ? | - |
? | |
3.4.21.53 | StpA + H2O | - |
Escherichia coli | ? | - |
? | |
3.4.21.53 | SulA + H2O | - |
Escherichia coli | ? | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
3.4.21.53 | hexamer | crystallography | Escherichia coli |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.4.21.53 | lon | - |
Salmonella enterica subsp. enterica serovar Typhimurium |
3.4.21.53 | lon | - |
Brevibacillus brevis |
3.4.21.53 | lon | - |
Escherichia coli |
3.4.21.53 | lon | - |
Homo sapiens |
3.4.21.53 | lon | - |
Saccharomyces cerevisiae |
3.4.21.53 | lon | - |
Proteus mirabilis |
3.4.21.53 | lon | - |
Yersinia pestis |
3.4.21.53 | lon | - |
Pseudomonas syringae |
3.4.21.53 | lon | - |
Caulobacter vibrioides |
3.4.21.53 | lon | - |
Streptomyces lividans |
3.4.21.53 | lon ATP-dependent protease | - |
Salmonella enterica subsp. enterica serovar Typhimurium |
3.4.21.53 | lon ATP-dependent protease | - |
Brevibacillus brevis |
3.4.21.53 | lon ATP-dependent protease | - |
Bacillus subtilis |
3.4.21.53 | lon ATP-dependent protease | - |
Escherichia coli |
3.4.21.53 | lon ATP-dependent protease | - |
Homo sapiens |
3.4.21.53 | lon ATP-dependent protease | - |
Saccharomyces cerevisiae |
3.4.21.53 | lon ATP-dependent protease | - |
Proteus mirabilis |
3.4.21.53 | lon ATP-dependent protease | - |
Myxococcus xanthus |
3.4.21.53 | lon ATP-dependent protease | - |
Yersinia pestis |
3.4.21.53 | lon ATP-dependent protease | - |
Pseudomonas syringae |
3.4.21.53 | lon ATP-dependent protease | - |
Caulobacter vibrioides |
3.4.21.53 | lon ATP-dependent protease | - |
Vibrio parahaemolyticus |
3.4.21.53 | lon ATP-dependent protease | - |
Streptomyces lividans |
3.4.21.53 | lonA | - |
Bacillus subtilis |
3.4.21.53 | lonB | - |
Bacillus subtilis |
3.4.21.53 | lonD | - |
Myxococcus xanthus |
3.4.21.53 | lonS | - |
Vibrio parahaemolyticus |
3.4.21.53 | lonV | - |
Myxococcus xanthus |
3.4.21.53 | PIM1 | - |
Saccharomyces cerevisiae |