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Literature summary extracted from

  • Asensio, A.C.; Rodriguez-Ferrer, C.R.; Castaneyra-Perdomo, A.; Oaknin, S.; Rotllan, P.
    Biochemical analysis of ecto-nucleotide pyrophosphatase phosphodiesterase activity in brain membranes indicates involvement of NPP1 isoenzyme in extracellular hydrolysis of diadenosine polyphosphates in central nervous system (2007), Neurochem. Int., 50, 581-590.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.4.1 Ca2+ maximal effect around 2 mM Rattus norvegicus
3.1.4.1 Mg2+ maximal effect around 2 mM Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.1 ADPgammaS
-
Rattus norvegicus
3.1.4.1 alpha,beta-methylene-ADP
-
Rattus norvegicus
3.1.4.1 AMP
-
Rattus norvegicus
3.1.4.1 ATP
-
Rattus norvegicus
3.1.4.1 ATPgammaS
-
Rattus norvegicus
3.1.4.1 beta,gamma-methylene-ATP
-
Rattus norvegicus
3.1.4.1 diadenosine polyphosphate competitive Rattus norvegicus
3.1.4.1 diethyl dicarbonate
-
Rattus norvegicus
3.1.4.1 EDTA drastic reduction of activity Rattus norvegicus
3.1.4.1 heparin competitive Rattus norvegicus
3.1.4.1 suramin
-
Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.4.1 plasma membrane
-
Rattus norvegicus 5886
-
3.1.4.1 synaptosome
-
Rattus norvegicus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.4.1 Zn2+ required for reactivation of enzyme after treatment with EDTA Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.1 additional information Rattus norvegicus isoform NPP1 is involved in cleavage of extracellular diadenosine polyphosphates in brain ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.1 Rattus norvegicus
-
-
-

Renatured (Commentary)

EC Number Renatured (Comment) Organism
3.1.4.1 reactivation of enzyme after treatment with EDTA requires Zn2+ Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.1 brain no difference in enzyme activity between young and adult animals Rattus norvegicus
-
3.1.4.1 central nervous system
-
Rattus norvegicus
-
3.1.4.1 cerebellum highest enzyme activities in synaptic membranes from cerebellum, hypothalamus, hippocampus Rattus norvegicus
-
3.1.4.1 hippocampus highest enzyme activities in synaptic membranes from cerebellum, hypothalamus, hippocampus Rattus norvegicus
-
3.1.4.1 hypothalamus highest enzyme activities in synaptic membranes from cerebellum, hypothalamus, hippocampus Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.1 diethenoadenosine polyphosphate + H2O
-
Rattus norvegicus ethenoadenosine 5'-monophosphate + ethenoadenosine (n-1)5'-polyphosphate
-
?
3.1.4.1 additional information isoform NPP1 is involved in cleavage of extracellular diadenosine polyphosphates in brain Rattus norvegicus ?
-
?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.4.1 9
-
-
Rattus norvegicus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
3.1.4.1 6.5 9
-
Rattus norvegicus