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Literature summary extracted from

  • Staniszewska, M.M.; Nagaraj, R.H.
    Upregulation of glyoxalase I fails to normalize methylglyoxal levels: a possible mechanism for biochemical changes in diabetic mouse lenses (2006), Mol. Cell. Biochem., 288, 29-36.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.4.1.5 D-glucose 25 mM upregulates glyoxalase I activity and mRNA in LE cells when compared with either cells cultured with 5 mM glucose as control or with 20 mM L-glucose + 5 mM D-glucose Mus musculus

Application

EC Number Application Comment Organism
4.4.1.5 medicine upregulation of glyoxalase I in diabetes, this upregulation is inadequate to normalize methylglyoxal levels, which can lead to methylglyoxal retention and chemical modification of proteins Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.4.1.5 cytosol
-
 Mus musculus 5829
-

Organism

EC Number Organism UniProt Comment Textmining
4.4.1.5 Mus musculus
-
 Balb/c mice, C57BL6/J female mice
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.4.1.5 lens glyoxalase I activity and mRNA levels are elevated in diabetic lenses Mus musculus
-
4.4.1.5 additional information LE cell, lens epithelial cells, activity of the enzyme in hyperglycemic conditions is nearly 20% higher than in control conditions Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.4.1.5 glutathione + methylglyoxal
-
 Mus musculus S-D-lactoylglutathione
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.4.1.5 glyoxalase I
-
 Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.4.1.5 7
-
-
 Mus musculus