Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Banegas, I.; Prieto, I.; Vives, F.; Alba, F.; de Gasparo, M.; Segarra, A.B.; Hermoso, F.; Duran, R.; Ramirez, M.
    Brain aminopeptidases and hypertension (2006), J. Renin Angiotensin Aldosterone Syst., 7, 129-134.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.4.11.7 medicine the development of GluAP inhibitors as potential antihypertensive agents offers new perspectives of therapy Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.11.2 bestatin
-
 Rattus norvegicus
3.4.11.6 bestatin
-
 Rattus norvegicus
3.4.11.7 (R)-3-amino-4-mercaptobutane-1-sulfonic acid i.e. EC33 Rattus norvegicus
3.4.11.7 4,4'-dithio [bis[(3S)-3-aminobutyl sulfonic acid]] i.e. RB150 Rattus norvegicus
3.4.11.21 additional information not inhibited by amastatin, bestatin, or EDTA Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.11.2 microsome
-
 Rattus norvegicus
-
-
3.4.11.21 microsome
-
 Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.11.7 angiotensin II + H2O Rattus norvegicus angiotensin II: Asp-Arg-Val-Tyr-Ile-His-Pro-Phe aspartic acid + angiotensin III angiotensin III: Arg-Val-Tyr-Ile-His-Pro-Phe ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.11.2 Rattus norvegicus
-
-
-
3.4.11.6 Rattus norvegicus
-
-
-
3.4.11.7 Rattus norvegicus
-
 Wistar-Kyoto and Sprague-Dawley rat
-
3.4.11.21 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.11.2 brain
-
 Rattus norvegicus
-
3.4.11.7 brain
-
 Rattus norvegicus
-
3.4.11.21 brain
-
 Rattus norvegicus
-
3.4.11.21 kidney
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.11.2 angiotensin III + H2O
-
 Rattus norvegicus angiotensin IV + L-Arg
-
 ?
3.4.11.6 angiotensin III + H2O
-
 Rattus norvegicus angiotensin IV + ?
-
 ?
3.4.11.6 L-Arg-2-naphthylamide + H2O
-
 Rattus norvegicus L-Arg + 2-naphthylamine
-
 ?
3.4.11.7 angiotensin II + H2O angiotensin II: Asp-Arg-Val-Tyr-Ile-His-Pro-Phe Rattus norvegicus aspartic acid + angiotensin III angiotensin III: Arg-Val-Tyr-Ile-His-Pro-Phe ?
3.4.11.21 angiotensin I + H2O
-
 Rattus norvegicus Asp + des-Asp-angiotensin I
-
 ?
3.4.11.21 Asp-2-naphthylamide + H2O most susceptible substrate Rattus norvegicus Asp + 2-naphthylamine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.11.2 AlaAP
-
 Rattus norvegicus
3.4.11.2 aminopeptidase M
-
 Rattus norvegicus
3.4.11.2 LeuAP M
-
 Rattus norvegicus
3.4.11.2 microsomal leucine aminopeptidase
-
 Rattus norvegicus
3.4.11.6 ArgAP
-
 Rattus norvegicus
3.4.11.6 arginine aminopeptidase
-
 Rattus norvegicus
3.4.11.7 aminopeptidase A
-
 Rattus norvegicus
3.4.11.7 GluAP
-
 Rattus norvegicus
3.4.11.7 glutamyl aminopeptidase
-
 Rattus norvegicus
3.4.11.21 AspAP considered initially an alternative name for glutamyl aminopeptidase Rattus norvegicus