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Literature summary extracted from

  • Selvaraj, M.; Roy, S.; Singh, N.S.; Sangeetha, R.; Varshney, U.; Vijayan, M.
    Structural plasticity and enzyme action: crystal structures of Mycobacterium tuberculosis peptidyl-tRNA hydrolase (2007), J. Mol. Biol., 372, 186-193.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
3.1.1.29 purified recombinant enzyme, X-ray diffraction structure determination and analysis at 1.98 A, 2.35 A, and 2.49 A resolution, molecular replacement Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.29 peptidyl-tRNA + H2O Mycobacterium tuberculosis peptidyl-tRNA hydrolase cleaves the ester bond between tRNA and the attached peptide in peptidyl-tRNA in order to avoid the toxicity resulting from its accumulation and to free the tRNA available for further rounds in protein synthesis peptide + tRNA
-
 ?
3.1.1.29 peptidyl-tRNA + H2O Mycobacterium tuberculosis H37Rv peptidyl-tRNA hydrolase cleaves the ester bond between tRNA and the attached peptide in peptidyl-tRNA in order to avoid the toxicity resulting from its accumulation and to free the tRNA available for further rounds in protein synthesis peptide + tRNA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.29 Mycobacterium tuberculosis P9WHN7 gene pth, orf Rv1014c
-
3.1.1.29 Mycobacterium tuberculosis H37Rv P9WHN7 gene pth, orf Rv1014c
-

Reaction

EC Number Reaction Comment Organism Reaction ID
3.1.1.29 N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA structure-function relationship, residues Asp95 and His115 are involved in catalysis, overview Mycobacterium tuberculosis
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.29 peptidyl-tRNA + H2O peptidyl-tRNA hydrolase cleaves the ester bond between tRNA and the attached peptide in peptidyl-tRNA in order to avoid the toxicity resulting from its accumulation and to free the tRNA available for further rounds in protein synthesis Mycobacterium tuberculosis peptide + tRNA
-
 ?
3.1.1.29 peptidyl-tRNA + H2O peptidyl-tRNA hydrolase cleaves the ester bond between tRNA and the attached peptide in peptidyl-tRNA in order to avoid the toxicity resulting from its accumulation and to free the tRNA available for further rounds in protein synthesis Mycobacterium tuberculosis H37Rv peptide + tRNA
-
 ?
3.1.1.29 peptidyl-tRNAL + H2O cleavage of the ester bond between tRNA and the attached peptide in peptidyl-tRNA, substrate binding channel structure, overview Mycobacterium tuberculosis peptide + tRNA
-
 ?
3.1.1.29 peptidyl-tRNAL + H2O cleavage of the ester bond between tRNA and the attached peptide in peptidyl-tRNA, substrate binding channel structure, overview Mycobacterium tuberculosis H37Rv peptide + tRNA
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.29 peptidyl-tRNA hydrolase
-
 Mycobacterium tuberculosis
3.1.1.29 PTH
-
 Mycobacterium tuberculosis