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Literature summary extracted from

  • Rossig, L.; Urbich, C.; Bruhl, T.; Dernbach, E.; Heeschen, C.; Chavakis, E.; Sasaki, K.; Aicher, D.; Diehl, F.; Seeger, F.; Potente, M.; Aicher, A.; Zanetta, L.; Dejana, E.; Zeiher, A.M.; Dimmeler, S.
    Histone deacetylase activity is essential for the expression of HoxA9 and for endothelial commitment of progenitor cells (2005), J. Exp. Med., 201, 1825-1835.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.1.98 Butyrate inhibition of histone deacetylases, results in down-regulation of HoxA9 expression Mus musculus
3.5.1.98 MS-275 inhibition of histone deacetylases, results in down-regulation of HoxA9 expression Mus musculus
3.5.1.98 trichostatin A inhibition of histone deacetylases, results in down-regulation of HoxA9 expression Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.1.98 additional information Mus musculus histone deacetylases regulate the expression of HoxA9, which acts as a master switch to regulate the expression of prototypical endothelial-committed genes such as endothelial nitric oxide synthase, VE-cadherin, VEGF-R2, and mediates the shear stress-induced maturation of endothelial cells ?
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Organism

EC Number Organism UniProt Comment Textmining
3.5.1.98 Mus musculus
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.1.98 mononuclear cell
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Mus musculus
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.98 additional information histone deacetylases regulate the expression of HoxA9, which acts as a master switch to regulate the expression of prototypical endothelial-committed genes such as endothelial nitric oxide synthase, VE-cadherin, VEGF-R2, and mediates the shear stress-induced maturation of endothelial cells Mus musculus ?
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?