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Literature summary extracted from

  • Pifarre, P.; Garcia, A.; Mengod, G.
    Species differences in the localization of soluble guanylyl cyclase subunits in monkey and rat brain (2007), J. Comp. Neurol., 500, 942-957.
    View publication on PubMed

Application

EC Number Application Comment Organism
4.6.1.2 medicine limited species differences in sGC subunit distribution of primates and rodents. NO-cGMP signaling pathway may be involved in important brain functions such as memory formation, sensory processing, and behavior Rattus norvegicus
4.6.1.2 medicine limited species differences in sGC subunit distribution of primates and rodents. NO-cGMP signaling pathway may be involved in important brain functions such as memory formation, sensory processing, and behavior Macaca fascicularis

Organism

EC Number Organism UniProt Comment Textmining
4.6.1.2 Macaca fascicularis
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-
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4.6.1.2 Rattus norvegicus
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male Wistar rats
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.6.1.2 amygdala prominent for beta1 and to a lesser extent for the other subunits Rattus norvegicus
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4.6.1.2 anterior olfactory nucleus high expression of beta1 and moderate to low expression of both alpha subunits Rattus norvegicus
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4.6.1.2 basal ganglion
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Rattus norvegicus
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4.6.1.2 basal ganglion
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Macaca fascicularis
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4.6.1.2 brain alpha1 subunit most prominent Macaca fascicularis
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4.6.1.2 brain sGC beta1 is the most abundant and ubiquitous subunit Rattus norvegicus
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4.6.1.2 caudate putamen highest levels of mRNA for beta1, alpha1 and alpha2 subunits Rattus norvegicus
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4.6.1.2 caudate putamen mRNAs coding for all subunits high and homogeneously distributed Macaca fascicularis
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4.6.1.2 cerebellum alpha2 and beta1 abundant in Purkinje cells, small cells close to Purkinje cells express high levels of alpha1 mRNA, alpha2 and beta1 expression very high and homogeneous in the granule cell layer Rattus norvegicus
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4.6.1.2 cerebellum mRNA coding for beta1 and alpha2 subunits is high in Purkinje cells, small cells located close to the Purkinje cells, probably Bergmann glia, contain high densities of alpha1 mRNA. The granule cell layer is enriched in beta1 mRNA and shows moderate levels for alpha2 and low for alpha1 mRNA. The medial and lateral inferior olive nuclei show intense levels of beta1 Macaca fascicularis
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4.6.1.2 cerebral cortex all neocortical areas with high expression of all subunits, expression of the three subunits in all cortical layers, alpha1 subunit enriched in layer VI Macaca fascicularis
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4.6.1.2 cerebral cortex beta1 subunit mRNA widely distributed through all cortical areas and cell layers with higher intensity in layer V, alpha2 mRNA homogeneously distributed through all cortical layers and alpha1 expression higher in layers II–III and V Rattus norvegicus
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4.6.1.2 cerebral white matter low expression of all subunit mRNAs in many of the white matter tracts Macaca fascicularis
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4.6.1.2 cerebral white matter moderate expression of alpha1 and alpha2 mRNAs in many white matter tracts, beta1 mRNA expression is very low Rattus norvegicus
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4.6.1.2 dentate gyrus
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Rattus norvegicus
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4.6.1.2 hippocampus high levels of alpha2, and moderate levels of alpha1 and beta1 in the lateral amygdaloid nucleus. In the hippocampal formation the presence of alpha1 and alpha2 mRNA is higher in the dentate gyrus and in the presubiculum and lower in the different CA subfields, beta1 mRNA particularly enriched in the hippocampal fields. In the hilus, large neurons contain significantly higher levels of beta1 and alpha2 Macaca fascicularis
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4.6.1.2 hypothalamus expression of the beta1 subunit moderate in the ventromedial, dorsomedial, arcuate, and geniculate nuclei. In these hypothalamic nuclei levels for the alpha subunits are low, all three subunits show moderate levels in the interpeduncular nucleus Rattus norvegicus
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4.6.1.2 limbic system sGC alpha2 and beta1 subunits expressed strongly by dentate gyrus granule cells and CA1-CA3 pyramidal neurons, expression of alpha1 mRNA is high in CA2 pyramidal cells but low in the other CA subfields Rattus norvegicus
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4.6.1.2 midbrain alpha1 subunit mRNA with restricted distribution in mesencephalic areas, moderate to high levels in the dorsal aspects of the periaqueductal gray, vestibular lateral and medial nuclei, and in prepositus hypoglossal nuclei, low alpha1 and alpha2 mRNA in the dorsal raphe nucleus, pedunculopontine tegmental nucleus, and oculomotor nuclei. Expression for alpha subunits pronounced in pontine nuclei Macaca fascicularis
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4.6.1.2 midbrain high levels of beta1 but low levels of alpha subunits in superior colliculus, locus coeruleus presents high levels of beta1 and alpha1 subunits, ventral tegmental nucleus wiht moderate levels of expression for the three sGC subunits Rattus norvegicus
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4.6.1.2 additional information no alpha subunits in the substantia nigra Macaca fascicularis
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4.6.1.2 olfactory bulb high expression of beta1 and moderate to low expression of both alpha subunits Rattus norvegicus
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4.6.1.2 piriform area shows high levels of expression for beta1 mRNA and moderate for alpha1 and alpha2 mRNAs Rattus norvegicus
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4.6.1.2 subiculum shows high expression of beta1, moderate of alpha2, and low of alpha1 Rattus norvegicus
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4.6.1.2 substantia nigra moderate expression of beta1, alpha subunits expression is very low Rattus norvegicus
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4.6.1.2 thalamus high levels of mRNA for the three subunits in the medial habenula, in other thalamic nuclei mainly beta1 mRNA Rattus norvegicus
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4.6.1.2 thalamus many of the thalamic nuclei contain the three subunits, alpha1 and beta1 mRNA in both the anterior and posterior ventralis nuclei and in the pulvinar and reticular nuclei, alpha2 subunit mRNA is present at low levels in the pulvinar nucleus and barely detectable in other thalamic nuclei Macaca fascicularis
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Synonyms

EC Number Synonyms Comment Organism
4.6.1.2 sGC
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Rattus norvegicus
4.6.1.2 sGC
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Macaca fascicularis
4.6.1.2 soluble guanylyl cyclase
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Rattus norvegicus
4.6.1.2 soluble guanylyl cyclase
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Macaca fascicularis