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Literature summary extracted from

  • Rella, M.; Rushworth, C.A.; Guy, J.L.; Turner, A.J.; Langer, T.; Jackson, R.M.
    Structure-based pharmacophore design and virtual screening for novel angiotensin converting enzyme 2 inhibitors (2006), J. Chem. Inf. Model., 46, 708-716.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.17.23 1N-08795 90% inhibition at 0.2 mM Homo sapiens
3.4.17.23 1N-26923 93% inhibition at 0.2 mM Homo sapiens
3.4.17.23 1N-27714 89% inhibition at 0.2 mM Homo sapiens
3.4.17.23 1N-28616 93% inhibition at 0.2 mM Homo sapiens
3.4.17.23 1S-90995 11% inhibition at 0.2 mM Homo sapiens
3.4.17.23 1S-91206 75% inhibition at 0.2 mM Homo sapiens
3.4.17.23 3S-95223 40% inhibition at 0.2 mM Homo sapiens
3.4.17.23 4S-14713 70% inhibition at 0.2 mM Homo sapiens
3.4.17.23 4S-16659 76% inhibition at 0.2 mM Homo sapiens
3.4.17.23 5115980 1% inhibition at 0.2 mM Homo sapiens
3.4.17.23 7490938 20% inhibition at 0.2 mM Homo sapiens
3.4.17.23 7850455 20% inhibition at 0.2 mM Homo sapiens
3.4.17.23 7857351 27% inhibition at 0.2 mM Homo sapiens
3.4.17.23 7870029 11% inhibition at 0.2 mM Homo sapiens
3.4.17.23 additional information not inhibited by rentiapril, ceranopril, indolaprilat, zofenoprilat, spiraprilat, quinaprilat, perindoprilat, fosinoprilat, cilazaprilat, captopril, lisinopril, and enalaprilat Homo sapiens
3.4.17.23 T0507-4963 41% inhibition at 0.2 mM Homo sapiens
3.4.17.23 T0513-5544 4% inhibition at 0.2 mM Homo sapiens
3.4.17.23 T0515-3007 13% inhibition at 0.2 mM Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.17.23 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.17.23 (7-methoxycoumarin-4-yl)acetyl-APK(2,4-dinitrophenyl) + H2O
-
 Homo sapiens (7-methoxycoumarin-4-yl)acetyl-AP + N6-(2,4-dinitrophenyl)-L-lysine
-
 ?
3.4.17.23 angiotensin II + H2O
-
 Homo sapiens angiotensin-(1-7) + Phe
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.17.23 ACE2
-
 Homo sapiens
3.4.17.23 angiotensin converting enzyme 2
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.4.17.23 0.062
-
-
 Homo sapiens 4S-16659
3.4.17.23 0.08 4
-
 Homo sapiens 1S-91206
3.4.17.23 0.096
-
-
 Homo sapiens 1N-08795
3.4.17.23 0.116
-
-
 Homo sapiens 1N-28616
3.4.17.23 0.134
-
-
 Homo sapiens 1N-26923
3.4.17.23 0.179
-
-
 Homo sapiens 4S-14713