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Literature summary extracted from

  • Goping, I.S.; Sawchuk, T.; Underhill, D.A.; Bleackley, R.C.
    Identification of alpha-tubulin as a granzyme B substrate during CTL-mediated apoptosis (2006), J. Cell Sci., 119, 858-865.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.4.21.79 additional information role for granzyme B in the dismantling of the cytoskeleton. In the execution phase of apoptosis it may modify key structural proteins thus enabling the cell to be properly dismantled and eliminated by phagocytosis Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.79 EGTA inhibits granular granzyme B-mediated killing Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.79 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.21.79
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.79 additional information YT-Indy cell line Homo sapiens
-
3.4.21.79 natural killer cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.79 alpha-tubulin + H2O alpha-tubulin derived from HeLa S100 extracts or Jurkat S100 extracts is cleaved by grB in a caspase-independent manner. Cleavage occurs at D438. Polymerized and soluble alpha-tubulin can be cleaved Homo sapiens truncated alpha-tubulin
-
 ?
3.4.21.79 pro-caspase-3 + H2O
-
 Homo sapiens caspase-3 + ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.79 GrB
-
 Homo sapiens