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Literature summary extracted from

  • Segarra, A.B.; Wangensteen, R.; Ramirez, M.; Banegas, I.; Hermoso, F.; Vargas, F.; Vives, F.; Duran, R.; Alba, F.; de Gasparo, M.; Prieto, I.
    Atrial angiotensinase activity in hypothyroid, euthyroid, and hyperthyroid rats (2006), J. Cardiovasc. Pharmacol., 48, 117-120.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.11.7 membrane
-
 Rattus norvegicus 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.11.7 angiotensin II + H2O Rattus norvegicus angiotensin II: Asp-Arg-Val-Tyr-Ile-His-Pro-Phe aspartic acid + angiotensin III angiotensin III: Arg-Val-Tyr-Ile-His-Pro-Phe ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.11.7 Rattus norvegicus
-
 Sprague-Dawley rat
-
3.4.11.14 Rattus norvegicus
-
-
-
3.4.11.21 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.11.7 atrium
-
 Rattus norvegicus
-
3.4.11.7 hypothalamus
-
 Rattus norvegicus
-
3.4.11.7 kidney
-
 Rattus norvegicus
-
3.4.11.7 pituitary gland
-
 Rattus norvegicus
-
3.4.11.14 atrium
-
 Rattus norvegicus
-
3.4.11.14 heart
-
 Rattus norvegicus
-
3.4.11.21 atrium
-
 Rattus norvegicus
-
3.4.11.21 heart
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.4.11.7 0.000004
-
 soluble glutamyl aminopeptidase activity in the atrium of euthyroid adult male rats Rattus norvegicus
3.4.11.7 0.000004
-
 soluble glutamyl aminopeptidase activity in the atrium of hyperthyroid adult male rats Rattus norvegicus
3.4.11.7 0.000004
-
 soluble glutamyl aminopeptidase activity in the atrium of hypothyroid adult male rats Rattus norvegicus
3.4.11.7 0.000045
-
 membrane-bound glutamyl aminopeptidase activity in the atrium of hypothyroid adult male rats Rattus norvegicus
3.4.11.7 0.00005
-
 membrane-bound glutamyl aminopeptidase activity in the atrium of euthyroid adult male rats Rattus norvegicus
3.4.11.7 0.000065
-
 membrane-bound glutamyl aminopeptidase activity in the atrium of hyperthyroid adult male rats Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.11.7 angiotensin II + H2O angiotensin II: Asp-Arg-Val-Tyr-Ile-His-Pro-Phe Rattus norvegicus aspartic acid + angiotensin III angiotensin III: Arg-Val-Tyr-Ile-His-Pro-Phe ?
3.4.11.14 Ala-2-naphthylamide + H2O
-
 Rattus norvegicus Ala + 2-naphthylamine
-
 ?
3.4.11.21 angiotensin I + H2O
-
 Rattus norvegicus Asp + des-Asp-angiotensin I
-
 ?
3.4.11.21 Asp-2-naphthylamide + H2O
-
 Rattus norvegicus Asp + 2-naphthylamine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.11.7 aminopeptidase A
-
 Rattus norvegicus
3.4.11.7 angiotensinase A
-
 Rattus norvegicus
3.4.11.7 GluAP
-
 Rattus norvegicus
3.4.11.7 glutamyl aminopeptidase
-
 Rattus norvegicus
3.4.11.14 AlaAP
-
 Rattus norvegicus
3.4.11.14 alanyl aminopeptidase
-
 Rattus norvegicus
3.4.11.14 angiotensinase M
-
 Rattus norvegicus
3.4.11.21 AspAP
-
 Rattus norvegicus