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Literature summary extracted from
- Chymotrypsin B cached in rat liver lysosomes and involved in apoptotic regulation through a mitochondrial pathway (2008), J. Biol. Chem., 283, 8218-8228.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 3.4.21.1 | expressed in Escherichia coli BL21 (DE3) pLysS cells | Rattus norvegicus |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.21.1 | 3,4-dichloroisocoumarin | complete inhibition at 0.2 mM | Rattus norvegicus |  |
| 3.4.21.1 | Aprotinin | partial inhibition at 0.1 mg/ml | Rattus norvegicus | |
| 3.4.21.1 | chymostatin | complete inhibition at 0.25 mM | Rattus norvegicus | |
| 3.4.21.1 | additional information | not inhibited by benzamide and L-1-chloro-3-(4-tosylamido)-7-amino-2-heptanone | Rattus norvegicus | |
| 3.4.21.1 | N-p-tosyl-L-phenylalanine-chloromethyl ketone | complete inhibition at 5 mM | Rattus norvegicus | |
| 3.4.21.1 | Phenylmethylsulfonylfluoride | complete inhibition at 2 mM | Rattus norvegicus | |
| 3.4.21.1 | SERPINB3 | partial inhibition | Rattus norvegicus | |
| 3.4.21.1 | SERPINB4 | partial inhibition | Rattus norvegicus | |
| 3.4.21.1 | Soybean trypsin inhibitor | complete inhibition at 0.1 mg/ml | Rattus norvegicus |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.4.21.1 | lysosome | - |
Rattus norvegicus | 5764 | - |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.4.21.1 | 28000 | - |
SDS-PAGE | Rattus norvegicus |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.21.1 | Rattus norvegicus | P07338 | - |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.4.21.1 | SB-TI-Sepharose column chromatography | Rattus norvegicus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.21.1 | hepatoma cell | - |
Rattus norvegicus | - |
| 3.4.21.1 | liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.1 | BH3 interacting domain death agonist + H2O | - |
Rattus norvegicus | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.21.1 | chymotrypsin B | - |
Rattus norvegicus |
| 3.4.21.1 | Ctrb | - |
Rattus norvegicus |
| 3.4.21.1 | LBCP | - |
Rattus norvegicus |
| 3.4.21.1 | lysosomal Bid cleavage protease | - |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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