Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Davis, B.; Koster, G.; Douet, L.J.; Scigelova, M.; Woffendin, G.; Ward, J.M.; Smith, A.; Humphres, J.; Burnand, K.G.; Macphee, C.H.; Postle, A.D.
    Electrospray ionization mass spectrometry identifies substrates and products of lipoprotein-associated phospholipase A2 in oxidized human low density lipoprotein (2007), J. Biol. Chem., 283, 6428-6437.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.1.1.4 drug development development of Lp-PLA2 inhibitors as therapy for atherosclerosis Homo sapiens
3.1.1.4 pharmacology development of Lp-PLA2 inhibitors as therapy for atherosclerosis Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.4 SB222657
-
 Homo sapiens
3.1.1.47 SB222657
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.4 phosphatidylcholine + H2O Homo sapiens the lipoprotein-associated phospholipase A2 is present in vulnerable plaque regions where it acts on LDL phospholipid oxidation products to generate the pro-inflammatory lysophospholipids and oxidized non-esterified fatty acids, it predominantly circulates as a constituent of LDL particles, overview 1-acylglycerophosphocholine + a carboxylate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.4 Homo sapiens
-
-
-
3.1.1.47 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.4 additional information the lipoprotein-associated phospholipase A2 is present in vulnerable plaque regions of blood vessels, it predominantly circulates as a constituent of LDL particles Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.4 additional information long chain oxidized phosphatidylcholines represent quantitatively the most abundant phosphatidylcholine products of LDL oxidation, although they are less efficient as substrates for Lp-PLA2 than are the short chain oxidized phosphoatidylcholines Homo sapiens ?
-
 ?
3.1.1.4 phosphatidylcholine + H2O the lipoprotein-associated phospholipase A2 is present in vulnerable plaque regions where it acts on LDL phospholipid oxidation products to generate the pro-inflammatory lysophospholipids and oxidized non-esterified fatty acids, it predominantly circulates as a constituent of LDL particles, overview Homo sapiens 1-acylglycerophosphocholine + a carboxylate
-
 ?
3.1.1.4 phosphatidylcholine + H2O substrate is derived from human carotid artery plaques Homo sapiens 1-acylglycerophosphocholine + a carboxylate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.4 lipoprotein-associated phospholipase A2
-
 Homo sapiens
3.1.1.4 Lp-PLA2
-
 Homo sapiens
3.1.1.4 More cf. EC 3.1.1.34 Homo sapiens
3.1.1.47 lipoprotein-associated phospholipase A2
-
 Homo sapiens
3.1.1.47 Lp-PLA2
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.1.4 37
-
 assay at Homo sapiens