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Literature summary extracted from

  • Mayer, G.; Hamelin, J.; Asselin, M.; Pasquato, A.; Marcinkiewicz, E.; Tang, M.; Tabibzadeh, S.; Seidah, N.G.
    The regulated cell surface zymogen activation of the proprotein convertase PC5A directs the processing of its secretory substrates (2008), J. Biol. Chem., 283, 2373-2384.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.21.B26 additional information the activation of PC5A is stimulated by incubation of Y1 cells with adrenocorticotropic hormone or 8-Br-cAMP Mus musculus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.21.B26 expressed in Y1 cells Mus musculus
3.4.21.61 expressed in HEK-293 cells, COS-1 cells or Y1 cells Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.4.21.61 DeltaN218 in COS-1 cells only apparent upon co-expression of PC5A. Untreated Y1 cells secrete PCSK9-DeltaN218, stimulation with 8-Br-cAMP increases the level and especially that of the 34-kDa PCSK9 product Homo sapiens
3.4.21.61 R218S noncleavable mutant Homo sapiens
3.4.21.61 R469W natural mutation, cannot modify the ability of PC5A to produce the 34-kDa PCSK9 product in HEK293 cells Homo sapiens
3.4.21.61 R496W natural mutation, cannot modify the ability of PC5A to produce the 34-kDa PCSK9 product in HEK293 cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.61 additional information PC5A inactivates PCSK9 via direct and indirect cleavages. PC5A, furin, or ADAMTS-4, but not ADAMTS-5, generate a 34-kDa PCSK9 product Homo sapiens
3.4.21.61 TIMP-3 completely abolishes the production of the 34-kDa PCSK9 product Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.B26 membrane PC5A is complexed to its prosegment at the plasma membrane Mus musculus 16020
-

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.B26 Mus musculus Q04592
-
-
3.4.21.61 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.B26 ADAMTS-4 + H2O
-
 Mus musculus ?
-
 ?
3.4.21.B26 endothelial lipase + H2O
-
 Mus musculus ?
-
 ?
3.4.21.B26 Lefty protein + H2O
-
 Mus musculus ?
-
 ?
3.4.21.B26 PCSK9 + H2O
-
 Mus musculus truncated PCSK9-DELTAN218 + ?
-
 ?
3.4.21.B26 pyroglutamic acid-RTKR-7-amido-4-methylcoumarin + H2O
-
 Mus musculus pyroglutamic acid-RTKR + 7-amino-4-methylcoumarin
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.B26 PC5A
-
 Mus musculus
3.4.21.61 PCSK9
-
 Homo sapiens