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Literature summary extracted from

  • Miller, A.G.; Smith, D.G.; Bhat, M.; Nagaraj, R.H.
    Glyoxalase I is critical for human retinal capillary pericyte survival under hyperglycemic conditions (2006), J. Biol. Chem., 281, 11864-11871.
    View publication on PubMed

Application

EC Number Application Comment Organism
4.4.1.5 medicine glyoxalase I is critical for pericyte survival under hyperglycemic conditions, its inactivation and/or down-regulation by NO donor may contribute to pericyte death by apoptosis during early stages of diabetic retinopathy Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.4.1.5 into vector pCMS-EGFP, overexpression in HRP cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.4.1.5 (Z)-1-[N-(2-aminoethyl)-N-(2-ammonioethyl)amino]diazen-1-ium-1,2-diolate decreases glyoxalase I expression and activity relative to untreated control cells, cells undergo apoptosis, apoptosis increases further on co-incubation with high glucose Homo sapiens
4.4.1.5 S-4-bromobenzylglutathione cyclopentyl diester detanonoate, NO donor, competitive inhibitor, concentration-dependent down-regulation of glyoxalase I, increases intracellular methylglyoxal and causes apoptosis, overexpression of glyoxalase I protects against S-4-bromobenzylglutathione cyclopentyl diester-induced apoptosis under high glucose conditions Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
4.4.1.5 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.4.1.5 additional information HRP cell Homo sapiens
-
4.4.1.5 pericyte
-
 Homo sapiens
-
4.4.1.5 retina
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.4.1.5 glutathione + methylglyoxal
-
 Homo sapiens S-D-lactoylglutathione
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.4.1.5 glyoxalase I
-
 Homo sapiens