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Literature summary extracted from

  • Ye, M.; Wysocki, J.; William, J.; Soler, M.J.; Cokic, I.; Batlle, D.
    Glomerular localization and expression of angiotensin-converting enzyme 2 and angiotensin-converting enzyme: implications for albuminuria in diabetes (2006), J. Am. Soc. Nephrol., 17, 3067-3075.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.4.17.23 medicine ACE2 may be a target for therapeutic interventions that aim to reduce albuminuria and glomerular injury Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.17.23 MLN-4760
-
 Mus musculus
3.4.17.23 telmisartan specific angiotensin II type 1 receptor blocker Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.17.23 membrane
-
 Mus musculus 16020
-

Organism

EC Number Organism UniProt Comment Textmining
3.4.17.23 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.17.23 glomerulus
-
 Mus musculus
-
3.4.17.23 kidney ACE and ACE2 co-localized strongly in the apical brush border of the proximal tubule Mus musculus
-
3.4.17.23 podocyte
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.17.23 angiotensin II + H2O
-
 Mus musculus angiotensin-(1-7) + Phe
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.17.23 ACE2
-
 Mus musculus