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Literature summary extracted from

  • Johnston, J.B.; Walker, J.R.; Rothman, S.C.; Poulter, C.D.
    Type-2 isopentenyl diphosphate isomerase. Mechanistic studies with cyclopropyl and epoxy analogues (2007), J. Am. Chem. Soc., 129, 7740-7741.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.3.3.2 3-cyclopropylbut-3-en-1-yl trihydrogen diphosphate cyclopropyl-derivative of isopentenyl diphosphate, mechanism-based inhibitor Thermus thermophilus
5.3.3.2 3-oxiran-2-ylbut-3-en-1-yl trihydrogen diphosphate epoxy-derivative of isopentenyl diphosphate, mechanism-based inhibitor. The enzyme catalyzes formation of a stable covalent adduct between the inhibitor and FMNH2 in a reaction catalyzed by protonation of the epoxide moiety followed by nucleophilic addition of the cofactor Thermus thermophilus

Organism

EC Number Organism UniProt Comment Textmining
5.3.3.2 Thermus thermophilus
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